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[ CAS No. 740081-22-5 ]

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2D
Chemical Structure| 740081-22-5
Chemical Structure| 740081-22-5
Structure of 740081-22-5 *Storage: {[proInfo.prStorage]}

Quality Control of [ 740081-22-5 ]

Related Doc. of [ 740081-22-5 ]

SDS

Product Details of [ 740081-22-5 ]

CAS No. :740081-22-5MDL No. :MFCD26395271
Formula : C17H13ClFN3O3 Boiling Point : 454.4±45.0°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :361.75Pubchem ID :57476867
Synonyms :

Computed Properties of [ 740081-22-5 ]

TPSA : 73.3 H-Bond Acceptor Count : 7
XLogP3 : 3.9 H-Bond Donor Count : 1
SP3 : 0.12 Rotatable Bond Count : 5

Safety of [ 740081-22-5 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 740081-22-5 ]

  • Downstream synthetic route of [ 740081-22-5 ]

[ 740081-22-5 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 740081-22-5 ]
  • [ 848440-15-3 ]
  • 2
  • [ 179688-53-0 ]
  • [ 2106-04-9 ]
  • [ 740081-22-5 ]
YieldReaction ConditionsOperation in experiment
94.5 g With hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; water; at 20℃; for 0.5h;pH 2.0; 72 g of 4-hydroxy-6-acetoxy-7-methoxyquinazoline, 80.6 g of triphenylphosphine,56.7 g of 3-chloro-2-fluoroaniline was added to 720 g of tetrahydrofuran at 20 C.Add DIAD 62.2g,4h after dripping,Add 5% hydrochloric acid 500g, Adjust the pH value 2-3, and stir for 0.5h,Extract with 720 g of dichloromethane to remove impurities,Retain the water phase,The aqueous phase was made alkaline with a 20% aqueous sodium hydroxide solution, filtered, and the filter cake was washed with water to neutrality.94.5 g of 4-[(3-chloro-2-fluorophenyl) amino] -6-acetoxy-7-methoxyquinazoline was dried,Total molar yield in two steps: 83.7%
  • 3
  • [ 740081-22-5 ]
  • C26H23ClFN5O5 [ No CAS ]
  • 4
  • [ 740081-22-5 ]
  • C27H25ClFN5O5 [ No CAS ]
  • 5
  • [ 740081-22-5 ]
  • C37H41ClFN5O9 [ No CAS ]
  • 6
  • [ 740081-22-5 ]
  • C20H19ClFN3O4 [ No CAS ]
  • 7
  • [ 740081-22-5 ]
  • potassium 4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-olate [ No CAS ]
YieldReaction ConditionsOperation in experiment
99% Taking compound 3 (100 mg) dissolved in methanol (2 ml) in, adding methanol and ammonia solution (7 N, 1 ml), and stirring at room temperature for 2 hours; then adding KOH solid (1 N, 15.6 mg), stirring at room temperature for 1 hour, the reaction solution turns on lathe does get compound 2 a (white powder, 98 mg, 99%),
  • 8
  • [ 740081-22-5 ]
  • N-(3-chloro-2-fluorophenyl)-7-methoxy-6-(piperidin-4-yloxy)quinazolin-4-amine trifluouroacetic acid [ No CAS ]
  • 9
  • [ 740081-22-5 ]
  • C22H24ClN5O3 [ No CAS ]
  • 10
  • [ 740081-22-5 ]
  • 2-(4-((4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)acetamide [ No CAS ]
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