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Chemical Structure| 749929-80-4 Chemical Structure| 749929-80-4

Structure of 749929-80-4

Chemical Structure| 749929-80-4

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Product Details of [ 749929-80-4 ]

CAS No. :749929-80-4
Formula : C10H8BrF2N
M.W : 260.08
SMILES Code : N#CC(C)(C)C1=C(F)C=C(Br)C=C1F

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Application In Synthesis of [ 749929-80-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 749929-80-4 ]

[ 749929-80-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 537033-52-6 ]
  • [ 74-88-4 ]
  • [ 749929-80-4 ]
YieldReaction ConditionsOperation in experiment
83% With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 - 20℃; for 3h; (4-bromo-2,6-difluoro-phenyl)-acetonitrile (0.4 g, 1.72 mmol) obtained in Preparation Example 149 was dissolvedin 2 mL of DMF and 2 mL of THF. NaH (60% in mineral oil, 0.152 g, 3.79 mmol) and iodomethane (0.236 mL,3.79 mmol) were added thereto at 0C, and the mixture was stirred at room temperature for 3 hours. After addition ofwater, the reaction solution was extracted with EtOAc. The organic layer was separated, dried with MgSO4 and purifiedby column chromatography to obtain the title compound (0.372 g, 83%). 1H-NMR (CDCl3) δ 7.12 (2H, m), 1.86 (6H, s).
 

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