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[ CAS No. 7506-66-3 ]

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2D
Chemical Structure| 7506-66-3
Chemical Structure| 7506-66-3
Structure of 7506-66-3 *Storage: {[proInfo.prStorage]}

Quality Control of [ 7506-66-3 ]

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Related Doc. of [ 7506-66-3 ]

SDS

Product Details of [ 7506-66-3 ]

CAS No. :7506-66-3MDL No. :MFCD00067706
Formula :C8H11NO2Boiling Point :330.8°C at 760 mmHg
Linear Structure Formula :-InChI Key :WLDMPODMCFGWAA-OLQVQODUSA-N
M.W :153.18Pubchem ID :6992236
Synonyms :

Computed Properties of [ 7506-66-3 ]

TPSA : 46.2 H-Bond Acceptor Count : 2
XLogP3 : 0.6 H-Bond Donor Count : 1
SP3 : 0.75 Rotatable Bond Count : 0

Safety of [ 7506-66-3 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 7506-66-3 ]

  • Upstream synthesis route of [ 7506-66-3 ]
  • Downstream synthetic route of [ 7506-66-3 ]

[ 7506-66-3 ] Synthesis Path-Upstream   1~9

  • 1
  • [ 136918-14-4 ]
  • [ 7506-66-3 ]
YieldReaction ConditionsOperation in experiment
94.11% With ruthenium trichloride; hydrogen In methanol at 250℃; for 30.00 h; Autoclave dd 30 g (0.20 mol) of phthalimide to a 1 L stainless steel magnetic stirring autoclave.A composite catalyst of 700 ml of methanol and 1.5 g of lanthanum chloride and copper powder supported alumina was used to seal the reaction vessel.After the air in the autoclave was replaced with nitrogen, the stirring was started to increase.When the temperature was raised to 250 ° C, the gauge pressure was 13.2 MPa. At this point, hydrogen is introduced.And pressurize to the pressure inside the kettle to 15Mpa. Insulation and pressure retention reaction for 30 hours, after the end of the heat preservation,Close the hydrogen inlet valve to cool to 10 ° C,After replacing the gas in the kettle with nitrogen, the liquid reaction solution was poured out. Filter, filter out the catalyst,The filtrate was transferred to a rotary evaporator.The methanol was distilled at atmospheric pressure, and after distilling off 600 ml of the distillate, the distillation was stopped. Cool to room temperature,A large amount of white granule crystals were precipitated, filtered through a Buchner funnel, and the filtrate and the distillate were combined.The filter cake was washed with 50 ml of water.The filter cake is dried to obtain 28.8 g of pure white crystalline powder, and the melting range is 138.8 ° C -140.3 ° C.The content of the liquid chromatographic analysis was 98.87percent. The selectivity of the reaction is 93.05percent, based on phthalimide.The yield was 94.11percent.
Reference: [1] Patent: CN108484476, 2018, A. Location in patent: Paragraph 0036; 0041; 0044; 0045; 0046; 0047; 0048
[2] Bulletin de la Societe Chimique de France, 1956, p. 906,910
  • 2
  • [ 13149-00-3 ]
  • [ 7506-66-3 ]
YieldReaction ConditionsOperation in experiment
88% at 100℃; for 2.00 h; General procedure: A mixture of a cyclic anhydride 1 (1 mmol), guanidiniumchloride (2) (1 mmol), Et3N (2 mmol) and FeCl3 (10 molpercent)in PEG-400 (0.5 mL) at 60°C for aromatic derivatives andat 100°C for aliphatic derivatives was stirred for an appropriatetime. The reaction progress was monitored by thinlayerchromatography. After the completion of the reaction,the reaction mixture was cooled to room temperature andthen was extracted with H2O and EtOAc. The organic layerwas dried over MgSO4 and then evaporated under reducedpressure. The residue was purified by column chromatographyon silica gel using n-hexane-EtOAc (7:3). The desired1H-isoindole-1,3(2H)-diones were obtained in 70–95percentyields. Spectroscopy data for compounds 3 are in goodagreement with those previously reported.
Reference: [1] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2016, vol. 71, # 9, p. 941 - 944
[2] Molecules, 2008, vol. 13, # 1, p. 157 - 169
[3] Heterocycles, 2006, vol. 68, # 8, p. 1559 - 1564
[4] Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987, vol. 42, # 11, p. 1424 - 1434
[5] Heterocycles, 1994, vol. 39, # 2, p. 729 - 740
  • 3
  • [ 1469-48-3 ]
  • [ 7506-66-3 ]
Reference: [1] Tetrahedron, 1999, vol. 55, # 31, p. 9439 - 9454
[2] Macromolecules, 2012, vol. 45, # 20, p. 8193 - 8200
[3] Patent: US5618812, 1997, A
  • 4
  • [ 1469-48-3 ]
  • [ 2555-11-5 ]
  • [ 7506-66-3 ]
Reference: [1] ChemCatChem, 2014, vol. 6, # 9, p. 2621 - 2625
  • 5
  • [ 85-42-7 ]
  • [ 7506-66-3 ]
Reference: [1] Heterocycles, 2006, vol. 68, # 11, p. 2259 - 2267
  • 6
  • [ 34112-17-9 ]
  • [ 7506-66-3 ]
Reference: [1] Chemistry - A European Journal, 2015, vol. 21, # 3, p. 1280 - 1285
  • 7
  • [ 2562-37-0 ]
  • [ 7506-66-3 ]
Reference: [1] Chemistry - A European Journal, 2015, vol. 21, # 3, p. 1280 - 1285
  • 8
  • [ 4720-86-9 ]
  • [ 7506-66-3 ]
Reference: [1] Chemische Berichte, 1931, vol. 64, p. 1981,1989
  • 9
  • [ 57-13-6 ]
  • [ 13149-00-3 ]
  • [ 7506-66-3 ]
Reference: [1] Journal of the Chemical Society, 1954, p. 3730,3753
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