Alternatived Products of [ 7545-23-5 ]
Product Details of [ 7545-23-5 ]
| CAS No. : | 7545-23-5 |
MDL No. : | MFCD00152656 |
| Formula : |
C18H37NO3
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | SKDZEPBJPGSFHS-UHFFFAOYSA-N |
| M.W : | 315.49 |
Pubchem ID : | 82045 |
| Synonyms : |
|
Application In Synthesis of [ 7545-23-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 7545-23-5 ]
- 1
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[ 111-42-2 ]
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[ 112-64-1 ]
-
[ 7545-23-5 ]
| Yield | Reaction Conditions | Operation in experiment |
| 62% |
With triethylamine In methanol |
|
|
With ammonia; tetra-(n-butyl)ammonium iodide In dichloromethane at 0℃; |
3.2 Step two,
12.56 g (0.12 mol) of diethanolamine was dissolved in a mixed solution of ammonia and methylene chloride (aqueous ammonia andDichloromethane in a volume ratio of 1: 9)The pH of the solution after dissolution was 9.5,And then added dropwise to the 1-chlorobutamate described in step 1,Followed by the addition of 2 g of catalyst tetrabutylammonium iodide,The amidation reaction was carried out in an ice bath at 0 ° C,The reaction process using ammonia to adjust the reaction solution pH value of 8 to 9,The reaction was followed by thin layer chromatography (TLC) to complete reaction with 1-chlorotetracin,The reaction product was washed with saturated sodium bicarbonate and then with saturated brine,Finally, extraction with dichloromethane,The extracted organic phase was dried over anhydrous magnesium sulfate and purified by silica gel column chromatography,The mobile phase used in silica gel column chromatography was dichloromethaneAnd methanol (in a volume ratio of CH2Cl2: CH3OH = 5: 1)To obtain myristic acid amide having a mass purity of 98% or more; |
| 1.44 g |
In dichloromethane at -10 - 20℃; |
|
Reference：
[1]Kiuchi; Nishizawa; Kawanishi; Kinoshita; Ohsima; Uchitani; Sekino; Ishida; Kondo; Tsuda
[Chemical and Pharmaceutical Bulletin, 1992, vol. 40, # 12, p. 3234 - 3244]
[2]Current Patent Assignee: NORTHWEST INSTITUTE FOR NONFERROUS METAL RESEARCH - CN106167506, 2016, A
Location in patent: Paragraph 0052
[3]De Rochambeau, Donatien; Sun, Yuanye; Barlog, Maciej; Bazzi, Hassan S.; Sleiman, Hanadi F.
[Journal of Organic Chemistry, 2018, vol. 83, # 17, p. 9774 - 9786]
| Yield | Reaction Conditions | Operation in experiment |
|
/BRN= 1791417/; |
|
|
|
The active compounds of the present invention include: lauric acid diethanolamide, myristic acid diethanolamide, palmitic acid diethanolamide, oleic acid diethanolamide, stearic acid diethanolamide, isostearic acid diethanolamide, linoleic acid diethanolamide, linolenic acid diethanolamide, and |
- 3
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[ 7545-23-5 ]
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[ 544-63-8 ]
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[ 111-42-2 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With Candida antarctica lipase In acetonitrile at 50℃; for 24h; |
|
- 4
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[ 544-63-8 ]
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[ 111-42-2 ]
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[ 7545-23-5 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With Candida antarctica lipase In acetonitrile at 50℃; for 24h; |
|
|
Stage #1: n-tetradecanoic acid; 2,2'-iminobis[ethanol] With benzotriazol-1-ol; triethylamine In dichloromethane for 0.25h; Cooling with ice;
Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Cooling with ice; |
|
Reference：
[1]Liu; Nag; Shaw
[Journal of agricultural and food chemistry, 2001, vol. 49, # 12, p. 5761 - 5764]
[2]Xun, Miao-Miao; Zhang, Xue-Chao; Zhang, Ji; Jiang, Qian-Qian; Yi, Wen-Jing; Zhu, Wen; Yu, Xiao-Qi
[Organic and Biomolecular Chemistry, 2013, vol. 11, # 7, p. 1242 - 1250]
- 5
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[ 7545-23-5 ]
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[ 106-89-8 ]
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[ 212916-07-9 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With tetrabutyl-ammonium chloride; sodium hydroxide In water at 0 - 20℃; for 12.5h; |
|
Reference：
[1]Xun, Miao-Miao; Zhang, Xue-Chao; Zhang, Ji; Jiang, Qian-Qian; Yi, Wen-Jing; Zhu, Wen; Yu, Xiao-Qi
[Organic and Biomolecular Chemistry, 2013, vol. 11, # 7, p. 1242 - 1250]
- 6
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[ 124-10-7 ]
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[ 111-42-2 ]
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[ 7545-23-5 ]
| Yield | Reaction Conditions | Operation in experiment |
| 78.45% |
With sodium hydroxide at 130℃; for 6h; |
3
A mixture of 24.23 g of methyl myristate (C13H27COOCH30.1 mol) was mixed with 12.09 g of diethanolamine (0.115 mol) in a three-necked flask equipped with a magnetic rotor, a condenser and a thermometer, and 0.22 g of sodium hydroxide was added to a three-necked flask (0.61% by mass of the total reactants) ). The flask was heated to 130 ° C in an oil bath. After stirring for 6 h, the mixture was cooled to dryness to give 24.75 myristate alkanolamide in a yield of 78.45% |
- 7
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[ 1120-71-4 ]
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[ 7545-23-5 ]
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C24H47NO9S2(2-)*2Na(1+)
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 60.12% |
With sodium hydroxide In tetrahydrofuran for 14h; Reflux; |
3
A solution of 12.20 g of propanesultone (0.1 mol) was dissolved in a volume of tetrahydrofuran, and 16.40 g (0.052 mol) of myristate alkanolamide was added thereto, and the mixture was sufficiently dissolved and charged with a magnetic rotor, a condenser, a thermometer (1.47% by mass of the total reactant) was added to the three-necked flask and heated to reflux temperature. After stirring for 14 h, the mixture was cooled to dryness to give 16.82 g of N, N- (1-ethoxy -) 3-sulfonic acid propyl myristyl sulfate sulfonate surfactant in a yield of 60.12%. |
- 8
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[ 7545-23-5 ]
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molybdenum(VI) oxide
[ No CAS ]
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C18H35MoNO5
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
In toluene at 105℃; Inert atmosphere; |
3.3 Step three,
The myristic acid amide described in step 2 was dissolved in toluene,Then add MoO3 solution,Under nitrogen protection,The temperature was 105 ° C under reflux conditions,The reaction was followed by thin layer chromatography (TLC) to the myristic acid reaction. After completion of the reaction, the water was distilled off,To obtain a brown viscous oil-soluble molybdenum amine complex;The preparation method of the MoO3 solution is:The MoO3 and deionized water were mixed to obtain a suspension,At a temperature of 50 ° C,To the suspension was added ammonia water to the suspension at a pH of 8,A MoO3 solution was obtained. |
- 9
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[ 7545-23-5 ]
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[ 40615-36-9 ]
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N-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)-N-(2-hydroxyethyl)tetradecanamide
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 843 mg |
With triethylamine In dichloromethane at 0 - 20℃; |
|
- 10
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[ 7545-23-5 ]
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2-(N-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)tetradecanamido)ethyl (2-cyanoethyl) diisopropylphosphoramidite
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere |
|
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