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Chemical Structure| 76471-08-4 Chemical Structure| 76471-08-4

Structure of 76471-08-4

Chemical Structure| 76471-08-4

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Product Details of [ 76471-08-4 ]

CAS No. :76471-08-4
Formula : C11H10N2O
M.W : 186.21
SMILES Code : NC1=CC=C(OC2=NC=CC=C2)C=C1
MDL No. :MFCD06825428
InChI Key :RTGVTQOURHFJEO-UHFFFAOYSA-N
Pubchem ID :13150574

Safety of [ 76471-08-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 76471-08-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 76471-08-4 ]

[ 76471-08-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 76471-08-4 ]
  • [ 1171919-75-7 ]
  • [ 2365-48-2 ]
  • methyl 3-amino-4-((4-(pyridin-2-yloxy)phenyl)amino)thieno[2,3-b]pyridine-2-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
43% To a solution of 4-(pyridin-2-yloxy)aniline 3.00 g, 16.1 mmol) and 2-chloro-4- iodopyridine-3-carbonitrile (5.539 g, 20.94 mmol) in dioxane (30 mL) were added DPEphos (1.735 g, 3.221 mmol), Pd(OAc)2(0.362 g, 1.61 mmol), and Cs2C03(10.498 g, 32.222 mmol) under a N2atmosphere and was stirred at 100 C for 4 h. After 4 h, methyl 2-mercaptoacetate (2.565 g, 24.17 mmol) was added and the reaction was stirred at 100 C overnight. The reaction was filtered to remove the solid and was concentrated to dryness. MeOH was added to the residue with stirring and the precipitate that formed was filtered. The precipitate was added to EtOAc, stirred, filtered, and dried under a vacuum to give the title compound (2.7 g, 43% yield) as a grey solid.
 

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