Home Cart Sign in  
Chemical Structure| 765310-73-4 Chemical Structure| 765310-73-4

Structure of 765310-73-4

Chemical Structure| 765310-73-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 765310-73-4 ]

CAS No. :765310-73-4
Formula : C11H22N2
M.W : 182.31
SMILES Code : NC1C(C2CCCCC2)NCCC1
MDL No. :MFCD20684622

Safety of [ 765310-73-4 ]

Application In Synthesis of [ 765310-73-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 765310-73-4 ]

[ 765310-73-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 101601-80-3 ]
  • [ 765310-73-4 ]
  • [ 58373-46-9 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; hydrogen;platinum on carbon; In water; at 18 - 22℃; under 4137.29 - 4654.46 Torr; for 0.5 - 7h; Demonstrates, in a pilot plant, an embodiment of the invention wherein 2-phenyl-3- aminopyridine was hydrogenated by contact with hydrogen in the presence of a 5% PT/C type 18MA catalyst. In a series of runs, approximately 8 kg of a 50% water wet catalyst paste formed of 5% PT/C type 18MA catalyst was fed into a stirred autoclave reactor (Hastelloy C). The paste was formed by admixing approximately 4kg of the dry catalyst with an amount of water commensurate yield to 50% water wet paste. Thereafter approximately 9kg of 2- phenyl-3-aminopyridine in a solution of 10% HCI/water was fed into the reactor, charged with H2 at a pressure of about 80 to about 90 psig. Reaction temperature was approximately 18 to ABOUT 22. The reaction proceeded for about 0.5 to about 7.0 hr, after which effluent from the reactor was sampled and analyzed in a HP-5 gas chromatograph (GC). An area percent report indicative of product amounts was generated. As appreciated by the artisan, a GC area percent correlates directly to amount of underlying product. In a first run, the area % for the desired product 2-phenyl-3-aminopiperidine was about 87.9% whereas that for the unwanted by-product of over-reduction, 2-cyclohexyl-3- aminopiperidine, was about 3.5%. In a second run, the area % for the desired product 2-phenyl-3-aminopiperidine was about 89.2% whereas that for the unwanted by-product of over-reduction, 2-CYCLOHEXYL-3- aminopiperidine, was about 5. 1%.Comparative Example 1 Demonstrates the prior art. The same conditions as in Example 1 were employed but for the use of Catalyst A, A 5% Pt/C catalyst (not type 18MA) previously used in the art to hydrogenate <strong>[101601-80-3]2-phenyl-3-aminopyridine</strong> to form 2-PHENYL-3-AMINOPIPERIDINE. GC values and area percent were assessed as in Example 1. In A first comparative run, the area % for the desired product 2-PHENYL-3- aminopiperidine was about 83. 2% WHEREAS THAT for the unwanted by-product of over- reduction, 2-CYCLOHEXYL-3-AMINOPIPERIDINE, was ABOUT 10. 2%. In a second comparative run, the area % for the desired product 2-phenyl-3- aminopiperidine was about 84. 5% whereas that for the unwanted by-product of over- reduction, 2-CYCLOHEXYL-3-AMINOPIPERIDINE, was about 9. 1%. The above results show A dramatic decrease in unwanted by-product via the inventive process as well as a concurrent increase in product yield. That is, in the inventive embodiment exemplified, the undesired production of 2-CYCLOHEXYL-3-AMINOPIPERIDINE impurity was reduced by over 50% on average whereas at the same time the sought-after product, 2- phenyl-3-aminopiperidine, showed an increase in overall yield.
 

Historical Records