[ CAS No. 766-39-2 ]

Name: 766-39-2|3,4-Dimethylfuran-2,5-dione|98%
Brand: Ambeed
SKU: A407814
Price: 6.0 USD
Availability: InStock
Rating: 99 (26 reviews)

{[proInfo.proName]} ,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

DV 2D 3D

Structure of 766-39-2 * Storage: {[proInfo.prStorage]}

Cart0 Bulk Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 88K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 766-39-2 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 766-39-2 ]

SDS

Alternatived Products of [ 766-39-2 ]

Product Details of [ 766-39-2 ]

CAS No. :	766-39-2	MDL No. :	MFCD00005523
Formula :	C₆H₆O₃	Boiling Point :	223°C at 760 mmHg
Linear Structure Formula :	-	InChI Key :	N/A
M.W :	126.11 g/mol	Pubchem ID :	13010
Synonyms :

Safety of [ 766-39-2 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H319	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 766-39-2 ]

Upstream synthesis route of [ 766-39-2 ]
Downstream synthetic route of [ 766-39-2 ]

[ 766-39-2 ] Synthesis Path-Upstream 1~7

1
[ 766-39-2 ]
[ 5754-17-6 ]

Yield	Reaction Conditions	Operation in experiment
99%	With hydrazine hydro-chloride In waterReflux	Hydrazine hydrochloride (58 g, 552 mmol) is dissolved in hot water (300 mL) and dimethyl maleic anhydride (58 g, 460 mmol) is added in portions and the suspension stirred at reflux for 16 h. The suspension is cooled down to room temperature and the precipitate is filtered, washed with water and dried at 40° C. under vacuum to yield 4,5-dimethyl-1,2-dihydro-pyridazine-3,6-dione (36) (64 g, 99percent).¹H-NMR (400 MHz, DMSO-d₆) δ=11 (br s, 2H), 2.01 (s, 6H).MS (m/z, MH+) meas. 141.1.

Reference： [1] Patent: US2010/41663, 2010, A1, . Location in patent: Page/Page column 41
[2] Journal of Organic Chemistry, 1955, vol. 20, p. 707,708
[3] Journal of the American Chemical Society, 1954, vol. 76, p. 4454,4457
[4] Patent: US2011/34451, 2011, A1, . Location in patent: Page/Page column 57
[5] Patent: US2011/34452, 2011, A1, . Location in patent: Page/Page column 36

2
[ 766-39-2 ]
[ 63751-07-5 ]
[ 5754-17-6 ]

Reference： [1] Journal of Organic Chemistry, 1955, vol. 20, p. 707,708

3
[ 766-39-2 ]
[ 34584-69-5 ]

Reference： [1] Patent: US2011/34451, 2011, A1,
[2] Patent: US2011/34452, 2011, A1,

4
[ 766-39-2 ]
[ 4282-29-5 ]

Reference： [1] Tetrahedron Letters, 2016, vol. 57, # 24, p. 2608 - 2611

5
[ 7397-06-0 ]
[ 766-39-2 ]
[ 32703-79-0 ]
[ 74186-27-9 ]
[ 95-47-6 ]

Reference： [1] J. Appl. Chem. USSR (Engl. Transl.), 1980, vol. 53, # 2, p. 353 - 355[2] Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1980, vol. 53, # 2, p. 418 - 420

6
[ 766-39-2 ]
[ 487-66-1 ]

Reference： [1] Patent: US2008/275057, 2008, A1,

7
[ 766-39-2 ]
[ 245124-18-9 ]

Reference： [1] Patent: US2008/275057, 2008, A1,

[ 766-39-2 ] Synthesis Path-Downstream 1~25

1
[ 766-39-2 ]
[ 604-44-4 ]
10-chloro-2,3-dimethyl-10<i>H</i>-anthracene-1,4,9-trione [ No CAS ]

Reference： [1]Chemische Berichte,1950,vol. 83,p. 178,180

2
[ 766-39-2 ]
[ 604-44-4 ]
9-chloro-10-hydroxy-2,3-dimethyl-anthracene-1,4-dione [ No CAS ]

Reference： [1]Chemische Berichte,1950,vol. 83,p. 178,180

3
[ 766-39-2 ]
[ 615-67-8 ]
6,7-dimethyl-2-chloronaphthazarin [ No CAS ]

Reference： [1]Chemische Berichte,1950,vol. 83,p. 178,180

4
[ 766-39-2 ]
[ 63751-07-5 ]
[ 5754-17-6 ]

Reference： [1]Journal of Organic Chemistry,1955,vol. 20,p. 707,708

5
[ 766-39-2 ]
[ 5754-17-6 ]

Yield	Reaction Conditions	Operation in experiment
99%	With hydrazine hydro-chloride; In water;Reflux;	Hydrazine hydrochloride (58 g, 552 mmol) is dissolved in hot water (300 mL) and dimethyl maleic anhydride (58 g, 460 mmol) is added in portions and the suspension stirred at reflux for 16 h. The suspension is cooled down to room temperature and the precipitate is filtered, washed with water and dried at 40 C. under vacuum to yield 4,5-dimethyl-1,2-dihydro-pyridazine-3,6-dione (36) (64 g, 99%).1H-NMR (400 MHz, DMSO-d6) delta=11 (br s, 2H), 2.01 (s, 6H).MS (m/z, MH+) meas. 141.1.
	With hydrazine dihydrochloride; at 100.0℃; for 3.0h;Inert atmosphere; Reflux;	Hydrazine dihydrochloride (83.6 g) was dissolved in water (20 ml), heated to 100 C., and 3,4-dimethylfuran-2,5-dione (100.4 g) was introduced while stirring. Then the mixture was heated to reflux for 3 h. Subsequently, the precipitate formed was filtered off with suction, washed with water and dried. The residue was suspended in EA (2 l), filtered off with suction, and was dried. 69.7 g of the title compound were obtained. LC-MS rt: 0.19 min [M+H]+: 141.1 (met. b)
	With hydrazine dihydrochloride; In water; at 100.0℃; for 3.0h;	W5.006 4,5-Dimethyl-1,2-dihydropyridazine-3,6-dione Hydrazine dihydrochloride (83.6 g) was dissolved in water (20 ml) and heated to 100 C., and 3,4-dimethylfuran-2,5-dione (100.4 g) was introduced while stirring. Then the mixture was heated to reflux for 3 h. Subsequently, the precipitate formed was filtered off with suction, washed with water and dried. The residue was suspended in EA (2 l), filtered off with suction and dried. 69.7 g of the title compound were obtained. LC-MS rt: 0.19 min[M+H]+: 141.1 (met. b)

Reference： [1]Patent: US2010/41663,2010,A1 .Location in patent: Page/Page column 41
[2]Journal of Organic Chemistry,1955,vol. 20,p. 707,708
[3]Journal of the American Chemical Society,1954,vol. 76,p. 4454,4457
[4]Patent: US2011/34451,2011,A1 .Location in patent: Page/Page column 57
[5]Patent: US2011/34452,2011,A1 .Location in patent: Page/Page column 36

6
[ 108-24-7 ]
[ 150-90-3 ]
[ 127-17-3 ]
[ 766-39-2 ]

Reference： [1]Justus Liebigs Annalen der Chemie,1892,vol. 267,p. 212

7
[ 7397-06-0 ]
[ 766-39-2 ]
[ 32703-79-0 ]
[ 74186-27-9 ]
[ 95-47-6 ]
4-tert-butyl-phthalaldehyde [ No CAS ]

Reference： [1]Journal of applied chemistry of the USSR,1980,vol. 53,p. 353 - 355
Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation),1980,vol. 53,p. 418 - 420

8
[ 766-39-2 ]
[ 1946-82-3 ]
(S)-2-Acetylamino-6-(3,4-dimethyl-2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexanoic acid [ No CAS ]

Reference： [1]Journal of Agricultural and Food Chemistry,1994,vol. 42,p. 2692 - 2697

9
[ 766-39-2 ]
hydrazine sulfate [ No CAS ]
[ 5754-17-6 ]
[ 6903-90-8 ]

Reference： [1]Journal of the American Chemical Society,1954,vol. 76,p. 4454,4457

10
[ 766-39-2 ]
[ 2015-19-2 ]
2-chloro-5-(2,5-dihydro-3,4-dimethyl-2,5-dioxo-1H-pyrrol-1-yl)benzenesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; In pyridine; (2S)-N-methyl-1-phenylpropan-2-amine hydrate;	SYNTHESIS EXAMPLE 4 Synthesis of preparation intermediate, 2-chloro-5-(2,5-dihydro-3,4-dimethyl-2,5-dioxo-1H-pyrrol-1-yl)benzenesulfonamide (Compound No. II-B-2) In 3 ml of pyridine, 1 mmol of <strong>[2015-19-2]5-amino-2-chlorobenzenesulfonamide</strong> and 1.05 mmol of 2,3-dimethylmaleic anhydride were stirred at 90-100 C. for 9 hours. Pyridine was then distilled off from the reaction mixture, followed by the addition of 20 ml of ice water and 0.1 ml of 35% hydrochloric acid to the solid residue. After the mixture thus formed was stirred for 20 minutes, the resulting precipitate was collected by filtration and then dried in air. Yield: 93%. Its physicochemical properties are shown in Table 8. The other compounds (Compound No. II-B-1 to Compound No. II-B-3) shown in Table 8 were also synthesised in a manner similar to Synthesis Example 4. The yield and physiocochemical properties of each of the compounds are also shown in Table 8.

Reference： [1]Patent: US5127937,1992,A

11
[ 766-39-2 ]
[ 2297-06-5 ]
methyl 2-(aminosulfonyl)-4-(2,5-dihydro-3,4-dimethyl-2,5-dioxo-1H-pyrrol-1-yl)benzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
43%	In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; acetic acid;	SYNTHESIS EXAMPLE 5 Synthesis of preparation intermediate, methyl 2-(aminosulfonyl)-4-(2,5-dihydro-3,4-dimethyl-2,5-dioxo-1H-pyrrol-1-yl)benzoate (Compound No. II-B-4) In 3 ml of acetic acid, 1 mmol of methyl 4-amino-2-(aminosulfonyl)benzoate and 1.05 mmol of 2,3-dimethylmaleic anhydride were stirred at 80 C. for 40 hours. Acetic acid was then distilled off from the reaction mixture, followed by the addition of 20 ml of ice water to the oily residue. After the mixture thus formed was stirred for 2 hours, the resulting precipitate was collected by filtration and then dried in air. Yield: 43%. Its physiocochemical properties are shown in Table 8.

Reference： [1]Patent: US5127937,1992,A

12
[ 766-39-2 ]
[ 40963-14-2 ]
[ 110498-08-3 ]

Yield	Reaction Conditions	Operation in experiment
69.9%	With sodium ethanolate; triethylamine; In ethanol;	PREPARATION EXAMPLE 2B 0.48 g (3.85 mmol) of 2,3-dimethylmaleic anhydride was added to a solution of 0.5 g (3.85 mmol) of <strong>[40963-14-2]2-amino-2,3-dimethylbutyramide</strong> and 0.6 ml (4.32 mmol) of triethylamine in 5 ml of dried ethanol while cooling in an ice bath so that the temperature did not exceed 30 C., and then stirred for 1 hour. All of an ethanol solution of sodium ethoxide, prepared by adding 0.20 g (8.70 mmol) of metallic sodium to 5 ml of dried ethanol, was added at the same time to the above solution without isolation of the formed triethylammonium salt of amidocarbamoylacrylic acid, and the resulting mixture was heated under reflux for 1 hour. The solvent was distilled away under reduced pressure, and the residue was treated in the same procedure as in Preparation Example 2A to yield 0.64 g of the same compound as in Preparation Example 2 (yield: 69.9%).

Reference： [1]Patent: US4726835,1988,A

13
[ 766-39-2 ]
[ 2365-85-7 ]
[ 115087-01-9 ]

Yield	Reaction Conditions	Operation in experiment
	In acetic acid;	EXAMPLE 1 Preparation of N-(2-fluoro-5-carboxyphenyl)-2,3-dimethylmaleic acid imide (intermediate) STR11 A mixture of 46.5 g of <strong>[2365-85-7]3-amino-4-fluorobenzoic acid</strong> and 37.8 g of dimethylmaleic anhydride in 200 ml of glacial acetic acid is stirred for 12 hours at an oil bath temperature of 130-40. After cooling, the mixture is poured onto ice-water, and the resulting precipitate is filtered with suction, washed with water and dried. Recrystallisation from ethanol/water yields 70.3 g of N-(2-fluoro-5-carboxyphenyl)-2,3-dimethylmaleic acid imide which melts at 238-240.

Reference： [1]Patent: US4804400,1989,A

14
[ 766-39-2 ]
[ 57946-56-2 ]
[ 115087-24-6 ]

Yield	Reaction Conditions	Operation in experiment
84%	With hydrogenchloride; dmap; sodium hydroxide; In o-xylene; ethyl acetate;	EXAMPLE 9 Preparation of N-(2-fluoro-4-chlorophenyl)-2,3-dimethylmaleic acid imide STR19 A mixture of 126 g (1.0 mol) of dimethylmaleic anhydride, 145.5 g (1.0 mol) of <strong>[57946-56-2]2-fluoro-4-chloroaniline</strong> and 2 g of 4-dimethylaminopyridine is heated under reflux in 800 ml of o-xylene for 16 hours using a water separator. The whole is then evaporated to dryness in vacuo and the residue is dissolved in a 1:1 mixture of ethyl acetate:ether and washed with each of 1N hydrochloric acid, 1N sodium hydroxide solution and water. Afer drying over sodium sulphate and evaporating off the solvent, the residue (227.5 g) is recrystallized from methanol. In this manner there are obtained 211.1 g (84% of the theoretical yield) of the title product in the form of colourless crystals which melt at 96-97.

Reference： [1]Patent: US4804400,1989,A

15
[ 766-39-2 ]
[ 39222-73-6 ]
[ 119096-63-8 ]

Yield	Reaction Conditions	Operation in experiment
94.8%	With pyrrolidine; acetic acid; In toluene; for 2.5h;Reflux;	0.45 g of pyrrolidine (6.4 mmoles) and 0.38 g of glacial acetic acid (6.4 mmoles) are added to a solution of 10.00 g of 2-amino-5-tert-butyl-1 , 3 , 4- thiadiazole (63.6 mmoles) - compound having formula (IX) - and 8.02 g of 2 , 3-dimethylmaleic anhydride (63.6 mmoles) - compound having formula (VIII) - in 60 ml of toluene. The solution is refluxed for 2 h 30' . Upon completion of the reaction, 50 ml of a 10% aqueous solution of HC1 are added to the solution, obtaining a biphasic system. After separating the organic phase, the aqueous phase is extracted with ethyl acetate. The combined organic phases are washed with a 10% solution of HC1, water and a saturated NaCl solution, anhydrified with anhydrous sodium sulfate, filtered and concentrated. The solid thus obtained is washed with cold heptane. 15.98 g of the desired product are obtained. Yield 94.8% (0288) GC-MS: M+ = 265
	With potassium carbonate; In dichloromethane; acetic acid;	EXAMPLE 2 Synthesis of an intermediate: STR33 2-Amino-5-tert-butyl-1,3,4-thiadiazole (1.57 g) and 2,3-dimethylmaleic anhydride (1.51 g) were refluxed for 5 hours in glacial acetic acid (30 ml). After the reaction, acetic acid and the excess of the 2,3-dimethylmaleic anhydride were evaporated. The residue was dissolved in dichloromethane (50 ml), and the solution was washed with a 10% aqueous solution of potassium carbonate (20 ml), and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the desired N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-2,3-dimethyl-maleinimide (2.41 g). mp. 87-91 C.

Reference： [1]Patent: WO2019/155400,2019,A1 .Location in patent: Page/Page column 54
[2]Patent: US4828604,1989,A

16
[ 766-39-2 ]
[ 34584-69-5 ]

Reference： [1]Patent: US2011/34451,2011,A1
[2]Patent: US2011/34452,2011,A1

17
[ 766-39-2 ]
[ 19763-90-7 ]
2-(3,4-dichlorophenyl)-6-hydroxy-4,5-dimethylpyridazin-3(2H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92.6%	With hydrogenchloride; In water; for 6h;Reflux;	1) Take 21.1 g of <strong>[19763-90-7]3,4-dichlorophenylhydrazine hydrochloride</strong>,12.6g of 3,4-dimethyl maleic anhydride was dissolved in 200ml of purified water was added.With stirring, slowly add 40 ml of concentrated hydrochloric acid.After the addition was completed, the mixture was heated under reflux for 6 hours.After completion of the reaction, the ice water bath was cooled to precipitate a yellow solid.Filter by suction and wash the filter cake twice with water.The filter cake was taken out and dissolved in saturated NaHCO3. The insoluble matter was filtered off, and the clear liquid was adjusted to pH between 2 and 3 with concentrated hydrochloric acid to precipitate a white solid.After suction filtration and drying, 26.3 g was obtained, and the yield was 92.6%.

Reference： [1]Patent: CN107793362,2018,A .Location in patent: Paragraph 0102; 0183; 0185; 0186
[2]Journal of Medicinal Chemistry,2016,vol. 59,p. 2942 - 2961

18
[ 766-39-2 ]
[ 4282-29-5 ]

Reference： [1]Tetrahedron Letters,2016,vol. 57,p. 2608 - 2611

19
[ 766-39-2 ]
[ 126-58-9 ]
C₄₆H₅₈O₂₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With 4-methoxy-phenol; In acetonitrile; for 6.5h;Reflux; Inert atmosphere;	In a 1 L flask with a condenser and a mechanical stirrer were added 1 mole of p-hydroxyanisole, 1.0 mole of dipentaerythritol, 6.0 mole of 2,3-dimethylmaleic anhydride and 300 grams of acetonitrile and the mixture was heated to reflux under nitrogen, after about 30 minutes, a light yellow clear liquid was obtained. The reaction temperature was maintained for 6 hours and then cooled to room temperature.

Reference： [1]Patent: CN105753694,2016,A .Location in patent: Paragraph 0042; 0043

20
[ 766-39-2 ]
[ 912368-73-1 ]
(S)-tert-butyl 3-(3,4-dimethyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)piperidine-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
6 g	With triethylamine; In toluene; at 20℃; for 16h;Reflux;	To a stirred solution of (S)-tert-butyl 3-(methylamino)piperidine- 1 -carboxylate (5 g, 25 mmol) in toluene (150 ml) was added triethylamine (5.42 ml, 37.5 mmol) followed by 3,4- dimethylfuran-2,5-dione (3.15 g, 2Smmol) at RT and the resulting reaction mixture was heated at reflux temperature for 16 h. The reaction mixture was cooled to RT and dilutedwith EtOAc and washed with water. The organic layer was dried and evaporated. The crude product was purified by flash chromatography to obtain 6.0 g of the product.?H NMR (300 MHz, CDC13) oe ppm 1.45 (s, 9H), 1.65- 1.83 (m, 2H), 1.95 (s, 6H), 2.05 - 2.29 (m, 2H), 2.60 - 2.75 (m, 1H), 3.22-3.35 (m, 1H), 3.92 - 4.10 (m, 3H).

Reference： [1]Patent: WO2018/2437,2018,A1 .Location in patent: Page/Page column 29

21
[ 766-39-2 ]
[ 912368-73-1 ]
(3S)-tert-butyl 3-((3R,4R)-dimethyl-2,5-dioxopyrrolidin-1-yl)piperidine-1-carboxylate [ No CAS ]

Reference： [1]Patent: WO2018/2437,2018,A1

22
[ 766-39-2 ]
[ 487-66-1 ]

Reference： [1]Patent: US2008/275057,2008,A1

23
[ 766-39-2 ]
[ 93-14-1 ]
C₂₂H₂₆O₁₀ [ No CAS ]

Reference： [1]Chemical Biology and Drug Design,2019,vol. 93,p. 262 - 271

24
[ 766-39-2 ]
[ 106797-53-9 ]
[ 121-44-8 ]
C₁₈H₂₂O₇*C₆H₁₅N [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		The structural formula of compound 4 is:2-Hydroxy-1-(4-(2-hydroxyethoxy)phenyl)-2-methylacetone (Darocur 2959) (33.69 g,0.15 mol), 2,3-dimethylmaleic anhydride (12.61 g, 0.1 mol), catalyst anhydrous AlCl3 (10.67, 0.08 mol) and 100 ml of toluene solution were added to 250 ml equipped with mechanical stirring and constant pressure dropping funnel. The mixture was stirred at 90 C for 60 min in a three-necked flask.After the reaction is completed, the solid impurities are removed by filtration, washed with water, separated by liquid three times to remove the aqueous phase, and the toluene is removed by rotary evaporation, and finally the solvent and water are removed by vacuum drying to obtain an intermediate product A;Intermediate product A and triethylamine (10.22 g, 0.1 mol) dissolved in 60 ml of pyridineAdd to a 250 ml three-necked flask equipped with a mechanical stirrer and a constant pressure dropping funnel.Stir at room temperature for 16 h.After completion of the reaction, it was washed three times with hydrochloric acid or ethyl acetate, and the solvent was removed by rotary evaporation, and further purified by a gel column to obtain a pure product 4, which was subjected to structural identification by nuclear magnetic resonance spectroscopy.

Reference： [1]Patent: CN109384670,2019,A .Location in patent: Paragraph 0037-0041

25
[ 766-39-2 ]
[ 49607-51-4 ]
3,4-dimethyl 1-(1-methyl-1H-1,2,4-triazol-3-yl)-1H-pyrrole-2,5-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
10%	With acetic acid; for 7h;Reflux;	3,4-Dimethylfuran-2,5-dione (550 mg, 4.36 mmol, 1.05 equiv) and <strong>[49607-51-4]1-methyl-1H-1,2,4-triazole-3-amine</strong> (407 mg, 4.15 mmol, 1.00 equiv) were dissolved in concentrated acetic acid (15 ml) and stirred under reflux conditions for 7 h. After cooling to room temperature, water and ethyl acetate were added and the mixture was extracted. The aqueous phase was repeatedly re-extracted vigorously with ethyl acetate, and the combined organic phases were then dried over magnesium sulfate, filtered and concentrated. Final purification by column chromatography of the resulting crude product (gradient ethyl acetate/heptane) gave 3,4-dimethyl 1-(1-methyl-1H-1,2,4-triazol-3-yl)-1H-pyrrole-2,5-dione in the form of a colorless solid (90 mg, 10% of theory). 1H-NMR (400 MHz, d6-DMSO delta, ppm) 8.09 (s, 1H), 3.75 (s, 3H), 2.01 (s, 6H).

Reference： [1]Patent: US2019/330192,2019,A1 .Location in patent: Paragraph 0200-0201

Related Products

Historical Records

Related Functional Groups of
[ 766-39-2 ]

Esters

[ 1462-12-0 ]

Diethyl 2-ethylidenemalonate

Similarity: 0.86

[ 638-10-8 ]

Ethyl 3-methylbut-2-enoate

Similarity: 0.82

[ 72985-23-0 ]

6-Methylisobenzofuran-1(3H)-one

Similarity: 0.78

[ 13222-85-0 ]

4-Methylbenzoic anhydride

Similarity: 0.78

[ 23405-32-5 ]

Methyl 1-oxo-1,3-dihydroisobenzofuran-5-carboxylate

Similarity: 0.78

Anhydrides

[ 13222-85-0 ]

4-Methylbenzoic anhydride

Similarity: 0.78

[ 93-97-0 ]

Benzoic anhydride

Similarity: 0.78

[ 36122-35-7 ]

3-Phenylfuran-2,5-dione

Similarity: 0.72

[ 27550-59-0 ]

5-Hydroxyisobenzofuran-1,3-dione

Similarity: 0.70

[ 1732-96-3 ]

Ethane-1,2-diyl bis(1,3-dioxo-1,3-dihydroisobenzofuran-5-carboxylate)

Similarity: 0.70

Related Parent Nucleus of
[ 766-39-2 ]

Furans

[ 497-23-4 ]

Furan-2(5H)-one

Similarity: 0.76

[ 61934-55-2 ]

4-(Bromomethyl)furan-2(5H)-one

Similarity: 0.75

[ 36122-35-7 ]

3-Phenylfuran-2,5-dione

Similarity: 0.72

[ 591-11-7 ]

5-Methylfuran-2(5H)-one

Similarity: 0.68

[ 5926-51-2 ]

3-Bromofuran-2,5-dione

Similarity: 0.61

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 766-39-2 ]

Quality Control of [ 766-39-2 ]

Related Doc. of [ 766-39-2 ]

Product Details of [ 766-39-2 ]

Safety of [ 766-39-2 ]

Application In Synthesis of [ 766-39-2 ]

[ 766-39-2 ] Synthesis Path-Upstream 1~7

[ 766-39-2 ] Synthesis Path-Downstream 1~25

Related Functional Groups of [ 766-39-2 ]

Esters

Anhydrides

Related Parent Nucleus of [ 766-39-2 ]

Furans

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 766-39-2 ]

Related Parent Nucleus of
[ 766-39-2 ]