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Chemical Structure| 773102-34-4 Chemical Structure| 773102-34-4

Structure of 773102-34-4

Chemical Structure| 773102-34-4

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Product Details of [ 773102-34-4 ]

CAS No. :773102-34-4
Formula : C10H8F4O2
M.W : 236.16
SMILES Code : FC(C1=CC(F)=CC=C1C2OCCO2)(F)F

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Application In Synthesis of [ 773102-34-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 773102-34-4 ]

[ 773102-34-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 107-21-1 ]
  • [ 90176-80-0 ]
  • [ 773102-34-4 ]
YieldReaction ConditionsOperation in experiment
51% With toluene-4-sulfonic acid; In toluene; at 140℃; for 4h;Dean-Stark; To a solution of commercially available <strong>[90176-80-0]4-fluoro-2-(trifluoromethyl)benzaldehyde</strong> (15 g, 78 mmol) in toluene (90 mL) was added ethylene glycol (21.77 mL, 390 mmol) and TsOH (0.743 g, 3.90 mmol). The mixture was then heated (under a Dean-Stark trap attached to a reflux condenser) in an oil bath at 140 C for 4 h, about 1.4-1.5 mL of water was collected, which was close to the expected volume. TLC (20% EtOAc-hexane) showed a major, new more polar spot. The mixture is diluted with EtOAc (100 mL) and washed with water (50 mL). The organic phase is washed with water (1 x 50 mL) and brine (50 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel column chromatography (330 g ISCO column) eluting with 0-10% EtOAc-hexane gradient. The cleanest fractions with product afforded 9.83 g (51% yield): MS (ESI): m/z 237 (M+H).
 

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