Alternatived Products of [ 777074-52-9 ]
Product Details of [ 777074-52-9 ]
CAS No. : | 777074-52-9 |
MDL No. : | MFCD20484579 |
Formula : |
C15H11FO3
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
258.24
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 777074-52-9 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 777074-52-9 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 777074-52-9 ]
- 1
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[ 193290-80-1 ]
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[ 100-39-0 ]
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[ 777074-52-9 ]
Yield | Reaction Conditions | Operation in experiment |
99% |
Stage #1: 3-fluoro-4-formylbenzoic acid With sodium hydride In N,N-dimethyl-formamide; mineral oil for 0.75h;
Stage #2: benzyl bromide In N,N-dimethyl-formamide; mineral oil |
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Stage #1: 3-fluoro-4-formylbenzoic acid With sodium hydride In DMF (N,N-dimethyl-formamide) at 20℃; for 0.75h;
Stage #2: benzyl bromide In DMF (N,N-dimethyl-formamide) at 20℃; for 5h; |
1 Reaction scheme 1; 3-Fluoro-4-formyl benzoic acid benzyl ester (6)
60% NaH (0. 23 mol) is added portionwise to a solution of 3-fluoro-4-formyl benzoic acid (3, 0.19 mol) in dry dimethylformamide (DMF) (570 mL). The mixture is stirred at room temperature for 45 min. Benzyl bromide (0.23 mol) is added dropwise to the mixture. After stirring at room temperature for 5h, the reaction mixture is poured into 1 N HCI (ca. 1000 mL) and extracted twice with EtOAc. The combined extracts are washed with saturated aqueous NaHCO3, brine, dried over MGS04, and evaporated in vacuo to give crude 3-fluoro-4-formyl benzoic acid benzyl ester (6). |
Reference:
[1]Location in patent: experimental part
Wagner, Carl E.; Jurutka, Peter W.; Marshall, Pamela A.; Groy, Thomas L.; Van Der Vaart, Arjan; Ziller, Joseph W.; Furmick, Julie K.; Graeber, Mark E.; Matro, Erik; Miguel, Belinda V.; Tran, Ivy T.; Kwon, Jungeun; Tedeschi, Jamie N.; Moosavi, Shahram; Danishyar, Amina; Philp, Joshua S.; Khamees, Reina O.; Jackson, Jevon N.; Grupe, Darci K.; Badshah, Syed L.; Hart, Justin W.
[Journal of Medicinal Chemistry, 2009, vol. 52, # 19, p. 5950 - 5966]
[2]Current Patent Assignee: NOVARTIS AG; Novartis (w/o Sandoz) - WO2004/89916, 2004, A1
Location in patent: Page 22-23