[ CAS No. 7778-83-8 ] {[proInfo.proName]}

Name: 7778-83-8|Propyl 3-Phenylacrylate|97%
Brand: Ambeed
SKU: A801753
Price: 6.0 USD
Availability: InStock
Rating: 93 (29 reviews)

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

DV 2D 3D

3d Animation Molecule Structure of 7778-83-8

Structure of 7778-83-8 * Storage: {[proInfo.prStorage]}

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 7778-83-8 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 7778-83-8 ]

SDS Specification

Alternatived Products of [ 7778-83-8 ]

Product Details of [ 7778-83-8 ]

CAS No. :	7778-83-8	MDL No. :	MFCD00051556
Formula :	C₁₂H₁₄O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	OLLPXZHNCXACMM-CMDGGOBGSA-N
M.W :	190.24	Pubchem ID :	5270647
Synonyms :

Calculated chemistry of [ 7778-83-8 ]

Physicochemical Properties

Num. heavy atoms :	14
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.25
Num. rotatable bonds :	5
Num. H-bond acceptors :	2.0
Num. H-bond donors :	0.0
Molar Refractivity :	57.05
TPSA :	26.3 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	Yes
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-4.96 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.81
Log Po/w (XLOGP3) :	3.52
Log Po/w (WLOGP) :	2.54
Log Po/w (MLOGP) :	2.77
Log Po/w (SILICOS-IT) :	2.94
Consensus Log Po/w :	2.92

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.22
Solubility :	0.114 mg/ml ; 0.000597 mol/l
Class :	Soluble
Log S (Ali) :	-3.76
Solubility :	0.0333 mg/ml ; 0.000175 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.38
Solubility :	0.0802 mg/ml ; 0.000422 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	2.0
Synthetic accessibility :	2.23

Safety of [ 7778-83-8 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P264-P273-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313	UN#:	N/A
Hazard Statements:	H315-H319-H413	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 7778-83-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 7778-83-8 ]

[ 7778-83-8 ] Synthesis Path-Downstream 1~24

1
[ 7778-83-8 ]
2,3-dibromo-3-phenyl-propionic acid propyl ester [ No CAS ]

Reference： [1]Chemische Berichte,1879,vol. 12,p. 538
Chemische Berichte,1878,vol. 11,p. 1220
[2]Chemische Berichte,1879,vol. 12,p. 538
Chemische Berichte,1878,vol. 11,p. 1220

2
[ 71-23-8 ]
[ 621-82-9 ]
[ 7778-83-8 ]

Reference： [1]Synthetic Communications,1992,vol. 22,p. 1087 - 1094
[2]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2003,vol. 42,p. 2828 - 2834
[3]Justus Liebigs Annalen der Chemie,1883,vol. 221,p. 83
Journal fuer Praktische Chemie (Leipzig),1900,vol. <2>61,p. 217 Anm. 3
[4]European Journal of Medicinal Chemistry,2011,vol. 46,p. 5498 - 5511
[5]Bioscience, Biotechnology and Biochemistry,2015,vol. 79,p. 1178 - 1182

3
[ 71-23-8 ]
cinnamic acid p-tosylhydrazide [ No CAS ]
[ 13326-06-2 ]
[ 7778-83-8 ]
[ 114376-01-1 ]

Reference： [1]Gazzetta Chimica Italiana,1981,vol. 111,p. 511 - 514

6
[ 67-56-1 ]
[ 7778-83-8 ]
[ 103-26-4 ]

Reference： [1]Tetrahedron Letters,2002,vol. 43,p. 879 - 882
[2]Synthesis,2003,p. 2479 - 2482

7
[ 71-23-8 ]
[ 103-26-4 ]
[ 7778-83-8 ]

Reference： [1]Tetrahedron Letters,2002,vol. 43,p. 879 - 882

8
[ 103-26-4 ]
[ 71-36-3 ]
[ 7778-83-8 ]

Reference： [1]Tetrahedron Letters,2002,vol. 43,p. 879 - 882

9
[ 7778-83-8 ]
[ 52392-64-0 ]

Reference： [1]Synthesis,2003,p. 2479 - 2482

10
[ 56289-55-5 ]
[ 7778-83-8 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogen;palladium 10% on activated carbon; In bmim NTf2;Reactivity (does not react);	The hydrogenation of allyl cinnamate can lead to the reduction either of the olefinic bonds, or even hydrogenolysis of the allyl functionality may be observed (Figure 8).Using both ILs, although no hydrogenolysis was observed in either the corresponding Bmim ILs nor the common organic solvent, ethyl acetate, 84 % selectivity was reached using IL (KG51) (Table 18).Table 18
	With hydrogen;palladium 10% on activated carbon; In Bmim OctOSO3;Reactivity (does not react);	The hydrogenation of allyl cinnamate can lead to the reduction either of the olefinic bonds, or even hydrogenolysis of the allyl functionality may be observed (Figure 8).Using both ILs, although no hydrogenolysis was observed in either the corresponding Bmim ILs nor the common organic solvent, ethyl acetate, 84 % selectivity was reached using IL (KG51) (Table 18).Table 18
	With hydrogen;palladium 10% on activated carbon; In 3-methyl-1-(2-(n-propoxy)ethoxycarbonylmethyl)imidazolium octylsulfate;Product distribution / selectivity;	The hydrogenation of allyl cinnamate can lead to the reduction either of the olefinic bonds, or even hydrogenolysis of the allyl functionality may be observed (Figure 8).Using both ILs, although no hydrogenolysis was observed in either the corresponding Bmim ILs nor the common organic solvent, ethyl acetate, 84 % selectivity was reached using IL (KG51) (Table 18).Table 18

	With hydrogen;palladium 10% on activated carbon; In 3-methyl-1-(propoxyethoxycarbonylmethyl)imidazolium trifluoromethanesulfonimide;Product distribution / selectivity;	The hydrogenation of allyl cinnamate can lead to the reduction either of the olefinic bonds, or even hydrogenolysis of the allyl functionality may be observed (Figure 8).Using both ILs, although no hydrogenolysis was observed in either the corresponding Bmim ILs nor the common organic solvent, ethyl acetate, 84 % selectivity was reached using IL (KG51) (Table 18).Table 18
	With hydrogen;palladium 10% on activated carbon; In ethyl acetate;Reactivity (does not react);	The hydrogenation of allyl cinnamate can lead to the reduction either of the olefinic bonds, or even hydrogenolysis of the allyl functionality may be observed (Figure 8).Using both ILs, although no hydrogenolysis was observed in either the corresponding Bmim ILs nor the common organic solvent, ethyl acetate, 84 % selectivity was reached using IL (KG51) (Table 18).Table 18

Reference： [1]Patent: WO2009/24607,2009,A1 .Location in patent: Page/Page column 39
[2]Patent: WO2009/24607,2009,A1 .Location in patent: Page/Page column 39
[3]Patent: WO2009/24607,2009,A1 .Location in patent: Page/Page column 39
[4]Patent: WO2009/24607,2009,A1 .Location in patent: Page/Page column 39
[5]Patent: WO2009/24607,2009,A1 .Location in patent: Page/Page column 39

11
[ 56289-55-5 ]
[ 13326-06-2 ]
[ 7778-83-8 ]

Reference： [1]Green Chemistry,2009,vol. 11,p. 466 - 474

12
[ 71-23-8 ]
[ 73789-34-1 ]
[ 7778-83-8 ]

Reference： [1]Journal of Organic Chemistry,2010,vol. 75,p. 3715 - 3721

13
[ 292638-84-7 ]
[ 71-23-8 ]
[ 201230-82-2 ]
[ 15895-95-1 ]
[ 7778-83-8 ]

Reference： [1]Catalysis Communications,2010,vol. 11,p. 1200 - 1204

14
[ 7778-83-8 ]
n-propyl thionocinnamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
88%	With tetraphosphorus decasulfide; In 1,4-dioxane;Reflux;	General procedure: The thionocinnamates 54refPreviewPlaceHolder1-61 were prepared by the sulfonation of their corresponding oxygenated cinnamates 13 and 47-53, refPreviewPlaceHolder[10] and refPreviewPlaceHolder[34] which in turn were prepared from the corresponding commercially available cinnamic acids and alcohols using P2S5 with little modification (refPreviewPlaceHolderScheme 5) to the literature reported procedure refPreviewPlaceHolder[35]. All the eight cinnamates (13 and 47-53) were freshly recrystallized prior to their use, and the solvent dioxane was freshly dried and distilled. A mixture of the oxygenated cinnamate 13/47-53 (100 mg) and P2S5 (1.5 equivalent) was refluxed in anhydrous dioxane (10 mL), the progress of the reaction was monitored by TLC. After completion of the reaction, the crude reaction mixture was poured into ice-cold water and extracted with ethyl acetate (3 × 30 mL). The combined organic layer was dried over sodium sulfate and evaporated in vacuo, and the residual oil was chromatographed on a silica gel column using petroleum ether. All the novel thionocinnamate 54-61 were fully and unambiguously identified on the basis of their spectral (IR, 1H NMR, 13C NMR spectra and HRMS) analysis.

Reference： [1]European Journal of Medicinal Chemistry,2011,vol. 46,p. 5498 - 5511

15
[ 71-23-8 ]
[ 104-55-2 ]
[ 7778-83-8 ]

Yield	Reaction Conditions	Operation in experiment
	With dihydrogen peroxide; at 60℃; for 3.0h;	General procedure: The catalytic reactions were performed in a round-bottomed flask equipped with a magnetic stirring bar and a reflux condenser. The oxidative esterification was carried out as follows: catalyst (20 mg), aldehyde (1 mmol) and alcohol (5 mmol) were magnetically stirred in the reaction flask at 60 C. H2O2 (2 mmol) was progressively added to the reaction mixture using a syringe. The reactions were stopped after 3 h and the excess hydrogen peroxide was deactivated by the addition of aq. sodium bisulfite. The catalyst was separated from the reaction mixture by filtration. As a two-layer mixture was obtained (organic phase/water phase) after the reaction, the organic products were separated from the aqueous phase by ethyl acetate extractions. The combined organic layers were washed with brine and dried over anhydrous Na2SO4, and then analyzed by GC-MS.

Reference： [1]Journal of Molecular Catalysis A: Chemical,2012,vol. 363-364,p. 291 - 303

16
[ 591-50-4 ]
[ 925-60-0 ]
[ 7778-83-8 ]

Yield	Reaction Conditions	Operation in experiment
64%Chromat.	With (tetra-n-butylammonium)2[Pd(N-4-methylphenyloxamate)2]2H2OMeCN; triethylamine; at 120℃; for 0.5h;Ionic liquid;Catalytic behavior;	General procedure: A test-tube with screw cap and valve was charged with a magnetic stir bar, the pre-catalyst 1mol % Pd, the aryl halide (0.50mmol), NEt3 (1.00mmol), the olefin (0.75mmol) and 2-3g of the ionic liquid. The reaction was heated under continuous stirring during 30min at 120C for n-Bu4NBr and in the temperature range 80-120C for the other ionic liquids, namely n-Bu4NCl, BMIMBr and BIMIMPF6. The reaction was monitored using thin liquid chromatography on silica gel. Workup was identical to that described above for the Suzuki reaction.

Reference： [1]Journal of Organometallic Chemistry,2013,vol. 743,p. 102 - 108

17
[ 7778-83-8 ]
[ 1621106-08-8 ]

Reference： [1]Synthesis,2014,vol. 46,p. 510 - 514

18
[ 7778-83-8 ]
[ 1621105-94-9 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium azide; ammonium cerium (IV) nitrate; In acetonitrile; at 0℃;Inert atmosphere;	General procedure: To a deoxygenated solution of ethyl cinnamate (176 mg, 1 mmol)and NaN3 (98 mg, 1.5 mmol) in anhydrous MeCN, a deoxygenatedsolution of CAN (1.370 g, 2.5 mmol) in the same solvent (10 mL)was added dropwise at 0 C and stirred well. H2O (400 mL) wasadded to the reaction mixture and the aqueous layer was extractedwith CH2Cl2 (4 × 150 mL). The combined organic extracts werewashed with H2O (2 × 100 mL), and dried over anhydrous Na2SO4.The crude residue, on treatment with anhydrous NaOAc (123 mg,1.5 mmol) in anhydrous acetone (5 mL), followed by usual workupand purification by silica gel column chromatography using petroleumether-EtOAc (98:2) as eluent, afforded 2a as a pale yellowviscous liquid.

Reference： [1]Synthesis,2014,vol. 46,p. 510 - 514

19
[ 71-23-8 ]
[ 300-57-2 ]
[ 7778-83-8 ]

Reference： [1]Chemical Communications,2015,vol. 51,p. 9575 - 9578

20
[ 109-99-9 ]
[ 35193-63-6 ]
[ 7778-83-8 ]
C₃₆H₃₄BrO₇P [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
70.7%	With N-Bromosuccinimide; at 20℃; for 30h;Inert atmosphere;	The substrate is used cinnamic acidPropyl ester (47.6mg, 0.2mmol) and (S) -1,1'- binaphthyl-2,2'-diyl hydrogen phosphate (73.1mg, 0.21mmol, 1.01Equiv.), Was addedAfter N- bromosuccinimide, 30h is reacted, and other experimental conditions were the same method as in Example 1, to obtain a colorless oily liquid 97.2mg, yield 70.7percent.Two non enantiomers by high performance liquid chromatography )The chalcone (41.6mg, 0.2mmol) and (R / S) -1,1'- binaphthyl-2,2'-diyl hydrogen phosphate (73.1mg, 0.21mmol, 1.01Equiv.) Was dissolved in 2mL<strong>[109-99-9]THF</strong> ; and at room temperature, under argon atmosphere, was slowly every 2hWas added N- bromosuccinimide (0.1mmol, 0.5Equiv.) For a total of 4 times was added, N- bromosuccinimide was added, reaction was continued for 24h, the solvent was removed under reduced pressure, the residue by column chromatography gel (ethyl acetate: n-hexane; (1: 10, V / V, 100mL), (1: 5, V / V100mL), (1: 3, V / V, 200mL)), to give a colorless oily liquid121.7mg, yield 86percent.The product form two diastereomers by high performance liquid.

Reference： [1]Patent: CN105524110,2016,A .Location in patent: Paragraph 0038; 0039; 0124; 0125; 0126; 0127

21
[ 621-82-9 ]
[ 7778-83-8 ]

Reference： [1]PLoS ONE,2017,vol. 12

22
[ 71-23-8 ]
[ 102-92-1 ]
[ 7778-83-8 ]

Yield	Reaction Conditions	Operation in experiment
	In dichloromethane; at 0℃; for 1.0h;	General procedure: Compounds A11-A15, A17, A18, A20-A22, B1-B12, C7-C10 and C13-C20 were preparedaccording to method B in Fig 1 by reaction of the corresponding acyl chloride and thecorresponding alcohol. The general procedure was as follows. The mixture of cinnamic acid orcinnamic acids with substituents on the phenyl ring (0.10 mol) and 30 mL thionyl chloridewas refluxed at 75C for 2 h. The excess thionyl chloride was removed under reduced pressure.After the residue was dissolved in 10 mL DCM, the corresponding alcohol (10 mmol) wasadded at 0C. The solution was stirred at 0C for 1 h, and then washed with water (3 × 30 mL)followed by 5% Na2CO3 aqueous solution, and dried over anhydrous sodium sulfate. After filtration,the solvent was removed under reduced pressure. The residue was purified by silica gelcolumn chromatography ( 40 mm × L 40 cm) to afford the desired product.

Reference： [1]PLoS ONE,2017,vol. 12

23
[ 109-60-4 ]
[ 100-52-7 ]
[ 7778-83-8 ]

Reference： [1]Green Chemistry,2017,vol. 19,p. 4838 - 4848

24
[ 540-54-5 ]
[ 621-82-9 ]
[ 7778-83-8 ]

Yield	Reaction Conditions	Operation in experiment
88%	With 1,1'-(hexane-1,6-diyl)bis(1,8-diazabicyclo[5.4.0]undec-7-enium) dichlorine; In ethanol; water; at 70℃; for 2.2h;Green chemistry;	General procedure: Carboxylic acids (1.00 mmol), primary chloroalkanes(1.20mmol) and IL-1 (0.30mmol) were added respectivelyinto a two necked flask equipped with 6mL 50%aqueous ethanol solution under stirring, then raised the systemtemperature to 70C for a needed time in water bath.The progress of the reaction was monitored using thin layer chromatography (TLC). When the reaction was over, thereactor was cooled down to room temperature. The mixturewas diluted with water (10mL) and extracted with ethylacetate (3 × 5mL), the extract was dried over anhydrousNa2SO4,filtered, and concentrated in a rotary evaporatorto collect target product. Meanwhile, the reborn catalystcould be applied in the next cycle was after removing thesolvent and dried at 80C under vacuum for 6h. All theesterification products were further purified by column

Reference： [1]Catalysis Letters,2017,vol. 147,p. 2764 - 2771

Same Skeleton Products

Related Products

Historical Records

Related Functional Groups of
[ 7778-83-8 ]

Aryls

[ 538-65-8 ]

Butyl cinnamate

Similarity: 0.98

[ 122-67-8 ]

Isobutyl cinnamate

Similarity: 0.95

[ 10032-08-3 ]

Heptyl cinnamate

Similarity: 0.95

[ 3487-99-8 ]

Pentyl cinnamate

Similarity: 0.95

[ 4192-77-2 ]

(E)-Ethyl cinnamate

Similarity: 0.95

Alkenes

[ 538-65-8 ]

Butyl cinnamate

Similarity: 0.98

[ 122-67-8 ]

Isobutyl cinnamate

Similarity: 0.95

[ 10032-08-3 ]

Heptyl cinnamate

Similarity: 0.95

[ 3487-99-8 ]

Pentyl cinnamate

Similarity: 0.95

[ 4192-77-2 ]

(E)-Ethyl cinnamate

Similarity: 0.95

Esters

[ 538-65-8 ]

Butyl cinnamate

Similarity: 0.98

[ 122-67-8 ]

Isobutyl cinnamate

Similarity: 0.95

[ 10032-08-3 ]

Heptyl cinnamate

Similarity: 0.95

[ 3487-99-8 ]

Pentyl cinnamate

Similarity: 0.95

[ 4192-77-2 ]

(E)-Ethyl cinnamate

Similarity: 0.95

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 7778-83-8 ] {[proInfo.proName]}

Quality Control of [ 7778-83-8 ]

Related Doc. of [ 7778-83-8 ]

Product Details of [ 7778-83-8 ]

Calculated chemistry of [ 7778-83-8 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 7778-83-8 ]

Application In Synthesis of [ 7778-83-8 ]

[ 7778-83-8 ] Synthesis Path-Downstream 1~24

Related Functional Groups of [ 7778-83-8 ]

Aryls

Alkenes

Esters

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 7778-83-8 ]