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Chemical Structure| 78118-88-4 Chemical Structure| 78118-88-4

Structure of 78118-88-4

Chemical Structure| 78118-88-4

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Product Details of [ 78118-88-4 ]

CAS No. :78118-88-4
Formula : C11H16N4O3
M.W : 252.27
SMILES Code : O=C(C1=CN=C(N2CCOCC2)N=C1N)OCC

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Application In Synthesis of [ 78118-88-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 78118-88-4 ]

[ 78118-88-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 110-91-8 ]
  • [ 774-07-2 ]
  • [ 78118-88-4 ]
YieldReaction ConditionsOperation in experiment
78.8% at 90℃;Inert atmosphere; A mixture of ethyl 4-amino-2-mercaptopyrimidine-5-carboxylate (30 g, 151 mmol) and morpholine (100 mL) was heated at 90 C. overnight under argon. The mixture was then cooled and concentrated under reduced pressure. The residue was taken up in dichloromethane (300 mL), washed successively with water (200 mL), brine (150 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give ethyl 4-amino-2-morpholinopyrimidine-5-carboxylate as a white solid. (Yield 30 g, 78.8%).
 

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