[ CAS No. 79544-27-7 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 79544-27-7
Chemical Structure| 79544-27-7
Structure of 79544-27-7

Quality Control of [ 79544-27-7 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 79544-27-7 ]

SDS

Product Details of [ 79544-27-7 ]

CAS No. :79544-27-7MDL No. :MFCD06797753
Formula :C7H3BrFNBoiling Point :-
Linear Structure Formula :-InChI Key :-
M.W :200.01Pubchem ID :2783139
Synonyms :

Computed Properties of [ 79544-27-7 ]

TPSA : 23.8 H-Bond Acceptor Count : 2
XLogP3 : 2.4 H-Bond Donor Count : 0
SP3 : 0.00 Rotatable Bond Count : 0

Safety of [ 79544-27-7 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 79544-27-7 ]

  • Upstream synthesis route of [ 79544-27-7 ]

[ 79544-27-7 ] Synthesis Path-Upstream   1~5

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YieldReaction ConditionsOperation in experiment
70%
Stage #1: With hydrogen bromide; sodium nitrite In 1,4-dioxane; water at 0℃; for 3.00 h;
Stage #2: With hydrogen bromide; copper(I) bromide In 1,4-dioxane; water at 0 - 50℃; for 0.58 h;
A mixture [OF 2, 6-DIFLUOROBENZONITRILE] (19.0 g, 137 mmol) and ethanol (200 ml) pre-saturated with ammonia gas was heated at [140°C] in an autoclave for 6 h (terminal pressure 200 psi). The mixture was allowed to cool to ambient temperature, evaporated to dryness and triturated with water (200 ml). The solid was filtered and left to air-dry to afford 2-amino- 6-fluorobenzonitrile (18.0 g, 97percent) as an off-white solid: [8H] (360 MHz, [CDCL3)] 4.53 (3H, s), 6.44-6. 52 (2H, m), 7.24-7. 30 [(1H, M).] 2-Amino-6-fluorobenzonitrile (18.0 g, 132 mmol) was dissolved in hot 1,4-dioxane (20 ml), 48percent hydrobromic acid (200 [ML)] was added and the mixture cooled to [0°C] before dropwise addition of sodium nitrite (10.5 g, 152 mmol) in water (20 [ML)] over 1.5 h. The resulting mixture was stirred at 0°C for 1.5 h then poured onto a cooled [(0°C)] solution of copper [(I)] bromide (56.8 g, 396 mmol) in 48percent hydrobromic acid (50 ml). The solution was stirred at [0°C] for 15 min then heated at [50°C] for 20 min. The mixture was cooled to ambient temperature, diluted with water (1200 [ML)] and extracted with ethyl acetate (2 x 400 [ML).] The combined organics were washed with [10percent] aqueous ammonia solution (400 ml), water (400 ml) and brine (500 ml), dried over anhydrous magnesium sulphate, filtered and evaporated to give an orange oil. Purification by chromatography on silica gel, eluting with isohexane on a gradient of ethyl acetate (2-4percent), gave 2- bromo-6-fluorobenzonitrile (18.5 g, 70percent) as a white solid: [8H] (400 MHz, [CDCL3)] 7.17-7. 23 [(1H,] ddd, [J8, 8] and 1), 7.44-7. 52 (2H, m). [2-BROMO-6-FLUOROBENZONITRILE] and [2- (2-FLUORO-5-NITROPHENYL)-4,] 4,5, 5- tetramethyl- [1, 3, [2]] dioxaborolane were coupled following the procedure in Example 2 to afford 3, 2'-difluoro-5'-nitrobiphenyl-2-carbonitrile as a black solid: [5H] (360 MHz, [CDCL3)] 7.32-7. 44 (3H, m), 7.71-7. 77 [(1H,] m), 8. 35-8. 41 (2H, m). 3, [2APOS;-DIFLUORO-5APOS;-NITROBIPHENYL-2-CARBONITRILE] was reduced following the procedure in Example 2 to give 5'-amino-3,2'-difluorobiphenyl-2- carbonitrile as a brown solid: [SN] (360 MHz, [CDCL3)] 3.74 (2H, s), 6.66-6. 75 (2H, m), 7.01 [(1H,] dd, J 9 and 9), 7.19-7. 30 (2H, m), 7.59-7. 65 [(1H,] m). 5'-Amino-3, 2'-difluorobiphenyl-2-carbonitrile was bromo-de- aminated following the procedure in Example 2 to give 5'-bromo-3,2'- difluorobiphenyl-2-carbonitrile as a white solid: AH (400 MHz, [CDCL3)] 7.13 [(1H,] dd, J 9 and 9), 7.27-7. 30 (2H, m), 7.53-7. 59 (2H, m), 7.64-7. 69 [(1H,] m). [5APOS;-BROMO-3,] [2APOS;-DIFLUOROBIPHENYL-2-CARBONITRILE WAS] converted, following the procedure in Example 2, to 3, [2APOS;-DIFLUORO-5APOS;- (5,] 5-dimethyl- [1, 3, 2] dioxaborinan-2-yl) biphenyl-2-carbonitrile, a brown oil that crystallised on standing: [SN] (360 MHz, [CDCL3)] 1.03 (6H, s), 3.77 (4H, s), 7.17-7. 25 (2H, m), 7.30 [(1H,] d, J8), [7.] 59-7.65 [(1H,] m), 7.81-7. 91 (2H, m). 3-Bromo-8-fluoro-7- [(1-HYDROXY-1-METHYLETHYL)] imidazo [1, 2-a] pyridine (0.10 g, 0.36 mmol) and 3, [2APOS;-DIFLUORO-5APOS;- (5, 5-DIMETHYL- [1,] 3,2] [DIOXABORINAN-] 2-yl) biphenyl-2-carbonitrile (0.16 g, 0.47 mmol) were coupled following the procedure in Example 1 to afford [3, 2APOS;-DIFLUORO-5APOS;- [8-FLUORO-7- (L-HYDROXY-L-] methylethyl) imidazo [1, 2-a] pyridin-3-yl] biphenyl-2-carbonitrile as a white amorphous solid (110 mg, 74percent): [8H] (360 MHz, [CDCL3)] 1.73 (6H, s), 2.10 [(1H,] s), 7.21 [(1H,] dd, J 7 and 7), 7.30 [(1H,] dd, J 8 and [8), 7. 38-7.] 44 (2H, m), 7.61-7. 72 (4H, m), 8. 23 [(1H,] d, [J 7) ; M/Z] (ES+) [408] [(M++H).]
Reference: [1] Patent: WO2003/99816, 2003, A1. Location in patent: Page 58
[2] Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 1173 - 1177
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YieldReaction ConditionsOperation in experiment
152 g at 100℃; for 2.00 h; 165 g of 2-fluoro-6-bromobenzaldehyde, 114 g of hydroxylamine hydrochloride and 450 g of formic acid were added to a 2 L single-necked flask and heated at 100 ° C for 2 hours. Distillation of formic acid, with sodium carbonate aqueous solution to adjust the pH value of 7 or so.Ethyl acetate was added to extract the oil layer, and 152 g of 2-fluoro-6-bromobenzonitrile was distilled off under reduced pressure,GC purity 98percent.
Reference: [1] Patent: CN106977535, 2017, A. Location in patent: Paragraph 0030
[2] Organic and Biomolecular Chemistry, 2018, vol. 16, # 42, p. 7959 - 7963
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Reference: [1] Chemical Communications, 2014, vol. 50, # 64, p. 8974 - 8977
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Reference: [1] Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 1173 - 1177
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Reference: [1] Patent: CN106977535, 2017, A
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