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Chemical Structure| 796062-15-2 Chemical Structure| 796062-15-2

Structure of 796062-15-2

Chemical Structure| 796062-15-2

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Product Details of [ 796062-15-2 ]

CAS No. :796062-15-2
Formula : C11H19NO3
M.W : 213.27
SMILES Code : O=C(N1CCC2OC2CC1)OC(C)(C)C
MDL No. :MFCD24543924

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Application In Synthesis of [ 796062-15-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 796062-15-2 ]

[ 796062-15-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 317336-73-5 ]
  • [ 796062-15-2 ]
YieldReaction ConditionsOperation in experiment
82% With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -60 - 20℃; To a stirred solution of 16.4 g <strong>[317336-73-5]2,3,6,7-tetrahydro-azepine-1-carboxylic acid tert-butyl ester</strong> in 420 ml dichloromethane was added at -60 C. 35.8 g m-chloroperbenzoic acid (70% purity). The mixture was allowed to slowly warm to room temperature overnight, 1 l ethylacetate was added and the solution was extracted with aqueous sodium bicarbonate, 1N aqueous sodium hydroxide and brine. Evaporation of the solvent and chromatography yielded 14.5 g (82%) 8-oxa-4-aza-bicyclo[5.1.0]octane-4-carboxylic acid tert-butyl ester as colorless liquid; MS (EI): m/e=213 (M+,5%), 158 (22%), 140 (12%), 57 (100%). To a solution of 14.3 g 8-oxa-4-aza-bicyclo[5.1.0]octane-4-carboxylic acid tert-butyl ester in 750 ethanol was added 150 ml water, 35.8 g ammonium chloride and 43.6 g sodium azide. The mixture was stirred at 75 C. over night, the solvents were greatly removed by distillation under vacuum and the residue was suspended in ethanol and filtered. The ethanol was distilled off and the residue was suspended in ethylacetate and filtered. Removal of the solvent and chromatography on silicagel with ethylacetate/hexane 1:1, yielded 13.5 g (79%) 4-azido-5-hydroxy-azepane-1-carboxylic acid tert-butyl ester as a viscous oil; MS (ISP): m/e=257 (M+H+).
 

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