Home Cart Sign in  
Chemical Structure| 79781-75-2 Chemical Structure| 79781-75-2

Structure of 79781-75-2

Chemical Structure| 79781-75-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 79781-75-2 ]

CAS No. :79781-75-2
Formula : C7H6N4O2
M.W : 178.15
SMILES Code : O=[N+](C1=CN=C(NC(C)=N2)C2=C1)[O-]

Safety of [ 79781-75-2 ]

Application In Synthesis of [ 79781-75-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 79781-75-2 ]

[ 79781-75-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 3537-14-2 ]
  • [ 64-19-7 ]
  • [ 79781-75-2 ]
YieldReaction ConditionsOperation in experiment
87% at 175℃; for 1.25h;Irradiation with microwave; A 10-20 mL Biotage Microwave reaction vial was charged with 5- nitropyridine-2,3 -diamine (85 mg, 0.55 mmol, Example 1, Step B) and acetic acid (5 mL). This mixture was subjected to microwave irradiation at 175C for 75 minutes and then poured into a saturated sodium bicarbonate solution (200 mL). The solution was extracted with 25% IPA/DCM (2 X), and the extracts were dried over sodium sulfate. The extracts were concentrated to a solid, 2-methyl-6-nitro-3H-imidazo[4,5-b]pyridine (85 mg, 87%). 1H NMR (400 MHz, DMSOd6) delta 13.43 (br s, IH), 9.15-9.17 (m, IH), 8.67-8.69 (m, IH), 2.61 (s, 3H); m/z (APCI-neg) M-I = 177.1.
  • 2
  • [ 108-24-7 ]
  • [ 3537-14-2 ]
  • [ 79781-75-2 ]
YieldReaction ConditionsOperation in experiment
With acetic acid; at 15 - 140℃; for 9.25h; EXAMPLE 12; Compound 11; N-(2-Methyl-3H-imidazo[4,5-b]pyrid-6-yl)-5-fluoro-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxamide; 12.1 2-Methyl-6-nitro-3H-imidazo[4,5-b]pyridine; 2.3 mL (24.33 mol) of acetic anhydride are added to a solution, stirred at 15 C., of 1.5 g (9.73 mmol) of <strong>[3537-14-2]2,3-diamino-5-nitropyridine</strong> in 15 mL of acetic acid. After stirring for 15 minutes at room temperature, the mixture is heated at 110 C. for 2 hours and then at 140 C. for 7 hours. The resulting mixture is concentrated under reduced pressure and taken up in 100 mL of water. A precipitate is collected by filtration. After purification by chromatography on a column of silica, 0.4 g of the expected product is obtained.LCMS: [MH]+=1791H NMR (DMSO D6), delta (ppm): 9.2 (d, 1H); 8.7 (d, 1H); 2.62 (s, 3H).
 

Historical Records