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Chemical Structure| 82302-17-8 Chemical Structure| 82302-17-8

Structure of 82302-17-8

Chemical Structure| 82302-17-8

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Product Details of [ 82302-17-8 ]

CAS No. :82302-17-8
Formula : C6H9N5O
M.W : 167.17
SMILES Code : N=C(C1=CN=C(C)N=C1N)NO

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Application In Synthesis of [ 82302-17-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 82302-17-8 ]

[ 82302-17-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 698-29-3 ]
  • [ 82302-13-4 ]
  • [ 7803-49-8 ]
  • [ 82302-17-8 ]
YieldReaction ConditionsOperation in experiment
With hydroxylamine hydrochloride; In dimethyl sulfoxide; EXAMPLE 5 4-Amino-2-methyl-5-pyrimidinecarboxamidoxime A solution of hydroxylamine base, prepared from hydroxylamine hydrochloride (7.296 g., 0.105 mole) and potassium t-butoxide (11.783 g., 0.105 mole) in dimethyl sulfoxide (200 ml.) in a manner similar to that of Example 1, is allowed to react with <strong>[698-29-3]4-amino-2-methyl-5-pyrimidine carbonitrile</strong> (13.414 g., 0.100 mole). After addition of dimethyl sulfoxide (50 ml.), the mixture is heated at 40+-1 C. for 92 hours. The solid which separates is collected by filtration, successively washed with methanol (1*50 ml.) and water (3*50 ml.) then dried at 110/0.1 mm. The yield of colorless crystals melting at 263 C. dec. (uncorr.) is 10.059 g. (60.2%). A second crop is obtained by concentrating the combined filtrates in vacuo to give a white solid. This material is washed with water, dried at 110 C./0.1 mm. The yield of colorless crystals melting at 256 C. dec. (uncorr.) is 6.300 g. (37.6%). The total yield of crude product is 16.359 g. (97.8%). The combined fractions are recrystallized from 2-methoxyethanol (Darco G-60) affording 7.887 g. (47.2%) of colorless prisms melting at 264 C. dec. (uncorr.). Concentration of the mother liquors yields a second crop of colorless prisms melting at 265 C. dec. (uncorr.) in a yield of 6.258 g. (37.4%) total yield is 14.145 g. (84.6%). Analysis for: C6 H9 N5 O; Calculated: C, 43.11; H, 5.42; N, 41.90; Found: C, 43.04; H, 5.35; N, 42.12.
 

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