[ CAS No. 826-55-1 ]

Name: 826-55-1|2-Methyl-2-phenylpropanoic acid|98%
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Product Details of [ 826-55-1 ]

CAS No. :	826-55-1	MDL No. :	MFCD00014332
Formula :	C₁₀H₁₂O₂	Boiling Point :	270.5°C at 760 mmHg
Linear Structure Formula :	-	InChI Key :	N/A
M.W :	164.20 g/mol	Pubchem ID :	13222
Synonyms :

Safety of [ 826-55-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 826-55-1 ]

Upstream synthesis route of [ 826-55-1 ]
Downstream synthetic route of [ 826-55-1 ]

[ 826-55-1 ] Synthesis Path-Upstream 1~8

1
[ 98-82-8 ]
[ 4522-40-1 ]
[ 826-55-1 ]
[ 536-66-3 ]
[ 5651-47-8 ]
[ 2438-04-2 ]

Reference： [1] Journal of the Chemical Society, 1954, p. 1079,1080, 1084
[2] Journal of the Chemical Society, 1954, p. 1079,1080, 1084

2
[ 98-82-8 ]
[ 88982-51-8 ]
[ 826-55-1 ]
[ 536-66-3 ]
[ 5651-47-8 ]
[ 2438-04-2 ]

Reference： [1] Journal of the Chemical Society, 1954, p. 1079,1080, 1084

3
[ 98-82-8 ]
[ 2875-37-8 ]
[ 826-55-1 ]
[ 536-66-3 ]
[ 5651-47-8 ]
[ 2438-04-2 ]

Reference： [1] Journal of the Chemical Society, 1954, p. 1079,1080, 1084

4
[ 98-82-8 ]
[ 1822-71-5 ]
[ 826-55-1 ]
[ 536-66-3 ]
[ 5651-47-8 ]
[ 2438-04-2 ]

Reference： [1] Journal of the Chemical Society, 1954, p. 1079,1080, 1084

5
[ 64-17-5 ]
[ 826-55-1 ]
[ 2901-13-5 ]

Yield	Reaction Conditions	Operation in experiment
96%	Stage #1: With thionyl chloride In dichloromethane for 15 h; Reflux	Example 1: Synthesis of 2,2-dimethylphenylacetic acid ethyl ester In a 10L reaction flask, add 2,2-dimethylphenylacetic acid(500g, 3.1mol), 2.5L methylene chloride solution. Stir at room temperature. Add thionyl chloride (750g, 6.3mol). Warmed the reaction system to reflux and react for 15H. Then slowly add dropwise 400mL of absolute ethanol and stir for some time. until the reaction was complete by TLC after adjusted to pH 9-10 with NaOHsolution, divided the organic layer was washed twice with saturated sodiumbicarbonate, and saturated sodium chloride twice and dried and concentrated togive 2,2-dimethylphenylacetic acid ethyl ester 560g, 96percent).
31 g	Reflux	1) the α,α-dimethyl-phenylacetic acid is dissolved in ethanol in water-free, α, α-dimethylphenyl acetic acid in the molar concentration of anhydrous ethanol is 1.5-2mol/L, then adding equivalent to α, α-dimethyl benzyl acetic acid weight 2-3percent solid loading a heteropolyacid catalyst PW₁₂/SiO₂, reflux reaction 2-3h, separating the catalyst, reducing pressure and evaporating ethanol filtrate, the residue is dissolved in dichloromethane, are sequentially water, saturated sodium bicarbonate aqueous solution and water, anhydrous magnesium sulphate dried after-filtration, filtrate reducing pressure and evaporating the solvent, the residue is distilled under reduced pressure to continue, collecting the fraction 130-133° C/85kPa, shall be colorless transparent liquid α, α-dimethylphenyl acetic acid ethyl ester;

Reference： [1] Patent: CN104276952, 2016, B, . Location in patent: Paragraph 0027; 0028
[2] MedChemComm, 2013, vol. 4, # 2, p. 367 - 370
[3] Tetrahedron, 2009, vol. 65, # 2, p. 456 - 460
[4] Journal of the American Chemical Society, 1968, vol. 90, p. 2082 - 2096
[5] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001, vol. 40, # 8, p. 717 - 718
[6] Patent: CN103333100, 2016, B, . Location in patent: Paragraph 0017; 0018

6
[ 101-97-3 ]
[ 74-88-4 ]
[ 826-55-1 ]
[ 2901-13-5 ]

Reference： [1] Pesticide Science, 1999, vol. 55, # 8, p. 850 - 856

7
[ 826-55-1 ]
[ 100510-65-4 ]

Reference： [1] MedChemComm, 2013, vol. 4, # 2, p. 367 - 370

8
[ 826-55-1 ]
[ 154477-55-1 ]

Reference： [1] Patent: CN106380441, 2017, A,

[ 826-55-1 ] Synthesis Path-Downstream 1~25

1
[ 98-82-8 ]
[ 88982-51-8 ]
[ 826-55-1 ]
[ 536-66-3 ]
[ 5651-47-8 ]
[ 2438-04-2 ]

Reference： [1]Journal of the Chemical Society,1954,p. 1079,1080, 1084

2
[ 98-82-8 ]
[ 2875-37-8 ]
[ 826-55-1 ]
[ 536-66-3 ]
[ 5651-47-8 ]
[ 2438-04-2 ]

Reference： [1]Journal of the Chemical Society,1954,p. 1079,1080, 1084

3
[ 98-82-8 ]
[ 4522-40-1 ]
[ 826-55-1 ]
[ 536-66-3 ]
[ 5651-47-8 ]
[ 2438-04-2 ]

Reference： [1]Journal of the Chemical Society,1954,p. 1079,1080, 1084
[2]Journal of the Chemical Society,1954,p. 1079,1080, 1084

4
[ 98-82-8 ]
[ 1822-71-5 ]
[ 826-55-1 ]
[ 536-66-3 ]
[ 5651-47-8 ]
[ 2438-04-2 ]

Reference： [1]Journal of the Chemical Society,1954,p. 1079,1080, 1084

5
[ 826-55-1 ]
[ 32454-35-6 ]

Yield	Reaction Conditions	Operation in experiment
81%		Example 3:; 2-Methyl-2-phenylpropanoic acid (5 g, 0.0304 moles) and water (50 ml) were added to three-necked round bottomed flask at ambient temperature (25 C to 30 C). To the resulting mixture, sodium carbonate solution (20% in water) was added dropwise until the pH was about 7. To the resulting solution 8.7 g of bromine was added dropwise while maintaining the pH of reaction solution at about 7 by addition of sodium carbonate solution. The reaction mixture was stirred until complete consumption of 2-methyl-2-phenylpropanoic acid as determined by gas chromatographic analysis. The neutral reaction solution was acidified with 5N hydrochloric acid to pH 1 to 2. The aqueous solution was extracted with dichloromethane (3x50 ml). All organic layers were combined, dried with anhydrous sodium sulphate and evaporated to dryness. The resulting solid product was suspended in hexanes (50 ml) and filtered to recover the product, 6.0 g, 81% yield, GC purity 98.5% of 2-(4-bromophenyl)-2-methylpropanoic acid and 1.25% of 2-(3-bromophenyl)-2-methylpropanoic acid.
46.6%		Step-2: Preparation of 2-(4-bromophenyl)-2-methylpropanoic acidThe wet material (on dry basis) from step-1 (275 Kg, assay 98%) was charged into a reactor containing 6875 L of water and 660 Kg of sodium bicarbonate. Bromine (330 Kg) was fed slowly into the reactor during 3 hours at 25-35 C. and maintained for 10 hours at 25-35 C. Toluene (275 L) was charged into reactor and stirred for 15 minutes. The aqueous phase was discharged into another reactor and pH adjusted to about 5 with dilute hydrochloric acid (880 L of water and 440 L of hydrochloric acid) at 0-10 C. The resultant material was filtered and washed with water. The obtained wet product was treated with heptanes (700 L) to recover 190 Kg (46.6% yield) of 2-(4-bromophenyl)-2-methylpropanoic acid, GC purity: 99.28% of 2-(4-bromophenyl)-2-methylpropanoic acid and 0.72% of 2-(3-bromophenyl)-2-methylpropanoic acid,

Reference： [1]Patent: EP2532644,2012,A1 .Location in patent: Page/Page column 5
[2]Patent: US2012/309973,2012,A1 .Location in patent: Page/Page column 3-4
[3]Journal of the American Chemical Society,1957,vol. 79,p. 3432,3437

6
[ 186581-53-3 ]
[ 826-55-1 ]
[ 57625-74-8 ]

Reference： [1]Bulletin de la Societe Chimique de France,1969,p. 787 - 790
[2]Canadian Journal of Chemistry,1990,vol. 68,p. 1106 - 1115

7
[ 67-56-1 ]
[ 826-55-1 ]
[ 57625-74-8 ]

Yield	Reaction Conditions	Operation in experiment
	With sulfuric acid; at 20℃; for 12h;Heating / reflux;	Methanol (2.5 LTR), 2,2-dimethyl-2-phenyl-acetic acid (Intermediate 1) (0.5 kg), and conc. sulphuric acid (50 ml) were charged to a reactor at room temperature. The temperature was raised to reflux and maintained for 12 hours. The pH was adjusted to 7-8 using aqueous ammonia and the methanol concentrated completely. The reaction mass was quenched in water (1 LTR) and extracted with MDC (750 ml). The MDC layer was dried over sodium sulphate and concentrated to obtain 500 gms of the title compound as an oil having 98% purity
	With sulfuric acid; at 25 - 45℃; for 4h;Heating / reflux;	(a) Reaction of alpha,alpha-Dimethyl phenyl acetic acid and methanol alpha,alpha-Dimethylphenyl acetic acid was reacted with methanol in presence of cone, sulfuric acid between about 25 to 45C. Reaction mixture was refluxed for about 4 hours. Methanol was distilled off after the said time to give thick oily slurry of Methyl-alpha,alpha-dimethylphenyl acetic acid. Water was added to the pre-cooled reaction mixture and extracted with chloroform EPO <DP n="8"/>followed by washing with aqueous sodium bicarbonate solution and finally with potable water. Removal of chloroform under reduced pressure yielded title compound as oily mass in about 98 % HPLC purity.EXAMPLE 1Methyl- a, a-Dimethyl phenyl acetate (ester)51 Kg (0.3109 Kmole) of alpha,alpha-Dimethyl acetic acid was dissolved in 100 to 150 Ltr methanol and to it was added concentrated sulfuric acid, 6 to 9 Kg maintaining temperature 25 to 450C. After complete addition of sulfuric acid reaction mixture was refluxed for 4 hours. After completion of the reaction methanol was distilled off under vacuum to obtain thick slurry which was cooled to room temperature and to it was added water. Reaction mixture was then extracted with chloroform and washed with 10% w/v sodium bicarbonate aqueous solution. Finally, chloroform layer was washed with potable water. On removal of chloroform under vacuum, Methyl-alpha,alpha-Dimethyl phenyl acetate as oily mass was obtained. HPLC Purity = 98%. Yield = 40 to 50 Kg
1 g	With methanesulfonic acid; for 2h;Sealed tube; Reflux;	A 100 mL sealed tube was charged with intermediate 39b (1.6 g, 9.7 mmol) and methanol (10 mL). To the above stirred solution CH3SO3H (1 .6 mL) was added drop wise and refluxed for 2 h. The reaction mixture concentrated and was diluted with ice- water and neutralized with NaHCO3, extracted with ethyl acetate, washed with water and dried. The product was obtained by concentrating under vacuo, which was further purified by combiflash to yield the title compound (1 .0 g) as a colourless liquid.H NMR: (ODd3, 300MHz) 6 7.25-7.27(d, 4H) 7.17-7.20 (m, 1H), 3.58 (5, 3H),1 .51 (5, 6H).

2 g

With sulfuric acid; at 0℃;Reflux;

To a stirred solution of 2-methyi-2-phenyipropanoic acid (2 g, 12.18 mmol) in methanol (30m1) at 0 was added drop wise solution of H2S04 (2 ml, 37.5 mmol), The reaction mixture was heated torefiux for overnight. After completion of reaction, methanol was evaporated under reduced pressure and the residue was diluted with dichioromethane. The organic portion was washed with saturatedsodium bicarbonate solution, brine and evaporated under reduced pressure to give methyl 2-methyl-2-phenyipropanoate (2 g) as oil.

Reference： [1]Journal of labelled compounds and radiopharmaceuticals,2011,vol. 54,p. 352 - 356
[2]Journal of Organic Chemistry,1994,vol. 59,p. 2792 - 2798
[3]Patent: WO2005/19175,2005,A1 .Location in patent: Page/Page column 23
[4]Patent: WO2007/7347,2007,A1 .Location in patent: Page/Page column 4; 6-7; 10
[5]Patent: WO2014/202528,2014,A1 .Location in patent: Page/Page column 107; 108
[6]Patent: WO2018/116072,2018,A1 .Location in patent: Page/Page column 75; 76; 79

8
[ 57625-74-8 ]
[ 826-55-1 ]

Yield	Reaction Conditions	Operation in experiment
98%	With water; sodium hydroxide; In 1,4-dioxane; for 24h;	Methyl 2-methyl-2-phenylpropanoate (0.840 g, 4.71 mmol) was dissolved in 5 mL of l,4-dioxane and 10 mL of 1.0 M NaOH (10.0 mmol, 2.1 equiv) was added. The mixture was heated at 95 C for 24 h. 20 mL of 1.0 M HC1 was added and the mixture was extracted with dichloromethane (3 x 20 mL). Combined organic fractions were washed with brine (30 mL), filtered through cotton and concentrated under reduced pressure to yield a crude mixture which was purified by flash chromatography (hexanes/ethyl acetate), 0.758 g of 2-methyl-2-phenylpropanoic acid (4.62 mmol, 98%).
89 g	With water; sodium hydroxide; In methanol; at 10℃; for 3h;Reflux;	Example-l: Preparation of 2-methyl-2-phenylpropanoic acid (FormuIa-3) Methyl 2-methyl-2-phenylpropanoate compound of formula-2 (100 gm) and methanol (500 ml) were added to a pre-cooled mixture of sodium hydroxide (45 gm) and water (500 ml) at 10-15C. Heated the reaction mixture to reflux temperature and stirred for 3 hrs at the same temperature. Distilled off the solvent completely from the reaction mixture under reduced pressure and cooled the reaction mixture to 25-30C. Water was added to the reaction mixture and cooled to 5-10C. Acidified the reaction mixture using dil.HCl solution at 5-10C. Raised the temperature of the reaction mixture to 25-30C and stirred for 30 rhin at the same temperature. Filtered the solid, washed with water and dried the material to get the title compound. Yield: 89.0 gm.
	With water; sodium hydroxide; In methanol; at 65℃;	General procedure: The ester II was added to a mixture of NaOH (2.0 M, 8 mL) and methanol (10 mL)and stirred overnight at 65 C. After removal of methanol in vacuo, the residue wasdiluted with water and extracted with EtOAc (10 mL × 3). Then the pH value of thewater layer was adjusted to 2.0 with HCl (2.0 M) and extracted with EtOAc (30 mL ×3). The combined organic phases were evaporated in vacuo to give the crudecarboxylic acid III, which was used directly for the next step without furtherpurification.

Reference： [1]Patent: WO2019/99760,2019,A1 .Location in patent: Paragraph 0055; 0058
[2]Synthesis,1985,p. 436 - 437
[3]Il Farmaco,1999,vol. 54,p. 600 - 610
[4]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 3887 - 3890
[5]Patent: WO2014/188453,2014,A2 .Location in patent: Page/Page column 22
[6]Chemical Communications,2017,vol. 53,p. 8316 - 8319
[7]Chinese Chemical Letters,2018,vol. 29,p. 191 - 193

9
[ 826-55-1 ]
methanol. H₂SO₄ [ No CAS ]
[ 57625-74-8 ]

Reference： [1]Journal of Organic Chemistry,1958,vol. 23,p. 1469,1472

10
[ 42826-42-6 ]
[ 826-55-1 ]
2,2-dimethyl-propionic acid <i>N</i>'-(2-methyl-2-phenyl-propionyl)-hydrazide [ No CAS ]

Reference： [1]Tetrahedron Letters,2006,vol. 47,p. 4827 - 4830

11
[ 826-55-1 ]
[ 57625-74-8 ]

Reference： [1]Journal of the American Chemical Society,1986,vol. 108,p. 4119 - 4125

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 6 Following the procedure of Example 1, the enol ether of isobutyrophenone of the formula STR10 is reacted with thallium (III) acetate to give methyl 2-methyl-2-phenylpropionate. This ester is hydrolyzed to yield 2-methyl-2-phenylpropionic acid.
		EXAMPLE 6 Following the procedure of Example 1, the enol ether of isobutyrophenone of the formula STR3 is reacted with thallium (III) aceetate to give methyl 2-methyl-2-phenylpropionate. This ester is hydrolyzed to yield 2-methyl-2-phenylpropionic acid.

13
[ 826-55-1 ]
[ 74-88-4 ]
[ 57625-74-8 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20℃; for 40h;	2-Methyl-2-phenyl-propionic acid methyl ester: 9.00 g (55 mmol) 2-methyl-2-phenyl-propionic acid was dissolved in 90 ml N,N-dimethylformamide, 11.51 g (2.5 eq.) of sodium hydrogencarbonate was added followed by 6.89 mL (15.72 g 2 eq.) of methyl iodide. The mixture was stirred at rt for 40 hours, then poured into ice water, the pH was adjusted to 3.0 with aq. HCl (1N) and the mixture extracted 3 times with ether; the organic phases were washed with water, dried over MgSO4, filtered and evaporated to give 7.34 g of the crude title compound as yellow oil. MS: 178.1 (M+).

Reference： [1]Patent: US2006/276508,2006,A1 .Location in patent: Page/Page column 31

14
[ 826-55-1 ]
[ 18107-18-1 ]
[ 57625-74-8 ]

Reference： [1]Synthesis,2008,p. 3835 - 3845

15
[ 154590-35-9 ]
[ 826-55-1 ]
C₂₅H₃₂FN₃O₃ [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 4022 - 4025

16
[ 826-55-1 ]
[ 17985-72-7 ]
C₂₀H₂₈O₂Si₂ [ No CAS ]

Reference： [1]Chemistry Letters,2012,vol. 41,p. 229 - 231

17
[ 826-55-1 ]
[ 100510-65-4 ]

Reference： [1]MedChemComm,2013,vol. 4,p. 367 - 370

18
[ 826-55-1 ]
[ 616-38-6 ]
[ 57625-74-8 ]

Reference： [1]Journal of Organic Chemistry,2013,vol. 78,p. 11606 - 11611

19
[ 30465-68-0 ]
[ 826-55-1 ]
C₂₀H₂₀N₂O₂ [ No CAS ]

Reference： [1]Chemistry - A European Journal,2014,vol. 20,p. 9530 - 9533

20
[ 30465-68-0 ]
[ 826-55-1 ]
1-(5-methoxyquinolin-8-yl)-3-methyl-3-phenylazetidin-2-one [ No CAS ]

Reference： [1]Chemistry - A European Journal,2014,vol. 20,p. 9530 - 9533

21
[ 75-75-2 ]
[ 826-55-1 ]
[ 57625-74-8 ]

Yield	Reaction Conditions	Operation in experiment
1.0 g	In methanol; for 2h;Sealed tube; Reflux;	A 100 mL sealed tube was charged with intermediate 39b (1.6 g, 9.7 mmol) and methanol (10 mL). To the above stirred solution, CH3SO3H (1.6 mL) was added drop wise and refluxed for 2 h. The reaction mixture concentrated and was diluted with ice-water and neutralized with NaHCO3, extracted with ethyl acetate, washed withwater and dried. The product was obtained by concentrating under vacuo, which wasfurther purified by combiflash to yield the title compound (1 .0 g) as a colourless liquid.1H NMR: (ODd3, 300MHz) 6 7.25-7.27(d, 4H) 7.17-7.20 (m, 1H), 3.58 (5, 3H),1 .51(s, 6H).

Reference： [1]Patent: WO2014/202580,2014,A1 .Location in patent: Page/Page column 113

22
[ 13061-96-6 ]
[ 826-55-1 ]
[ 57625-74-8 ]

Reference： [1]Journal of Organic Chemistry,2015,vol. 80,p. 7305 - 7310

23
[ 1128-56-9 ]
[ 826-55-1 ]
2-methyl-2-phenyl-N-(1-phenyl-1H-pyrazol-3-yl)propanamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
56%	With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; for 18h;	[362] To a solution of <strong>[1128-56-9]1-phenyl-1H-pyrazol-3-amine</strong> (60 mg, 0.38 mmol, 1.0 eq) and 2-methyl-2- phenylpropanoic acid (62 mg, 0.38 mmol, 1.0 eq) in DMF (2.0 mL) was added HBTU (143 mg, 0.38 mmol, 1.0 eq) and iPr2NEt (66 muL, 0.38 mmol, 1.0 eq). The resultant reaction mixture was stirred for 18 h at room temperature. The reaction mixture was partitioned between ethyl acetate and water. The layers were separated, and the organic layer was concentrated. The crude residue thus obtained was purified by C18 preparatory HPLC (acetonitrile/water with TFA modifier) to provide 2-methyl-2- phenyl-N-(1-phenyl-1H-pyrazol-3-yl)propanamide (66 mg, 56% yield).

Reference： [1]Patent: WO2018/107056,2018,A1 .Location in patent: Paragraph 362

24
[ 826-55-1 ]
[ 3910-35-8 ]
[ 201230-82-2 ]

Reference： [1]Dalton Transactions,2019,vol. 48,p. 1574 - 1577

25
[ 826-55-1 ]
[ 3910-35-8 ]

Reference： [1]Dalton Transactions,2019,vol. 48,p. 5725 - 5734

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P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 826-55-1 ]

Quality Control of [ 826-55-1 ]

Related Doc. of [ 826-55-1 ]

Product Details of [ 826-55-1 ]

Safety of [ 826-55-1 ]

Application In Synthesis of [ 826-55-1 ]

[ 826-55-1 ] Synthesis Path-Upstream 1~8

[ 826-55-1 ] Synthesis Path-Downstream 1~25

Related Functional Groups of [ 826-55-1 ]

Carboxylic Acids

Aryls

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 826-55-1 ]