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[ CAS No. 84057-84-1 ]

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type HazMat fee
Excepted Quantity Free
Ground (Domestic only) Free
Inaccessible (Haz class 6.1), Domestic USD 41.00
Inaccessible (Haz class 6.1), International USD 64.00
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 83.00
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2D
Chemical Structure| 84057-84-1
Chemical Structure| 84057-84-1
Structure of 84057-84-1 *Storage: {[proInfo.prStorage]}

Quality Control of [ 84057-84-1 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 84057-84-1 ]

SDS

Product Details of [ 84057-84-1 ]

CAS No. :84057-84-1MDL No. :MFCD00865333
Formula :C9H7Cl2N5Boiling Point :-
Linear Structure Formula :-InChI Key :-
M.W :256.09Pubchem ID :3878
Synonyms :

Computed Properties of [ 84057-84-1 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 84057-84-1 ]

Signal Word:DangerClass6.1
Precautionary Statements:P301+P310UN#:2811
Hazard Statements:H301Packing Group:
GHS Pictogram:

Application In Synthesis of [ 84057-84-1 ]

  • Downstream synthetic route of [ 84057-84-1 ]

[ 84057-84-1 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 879573-84-9 ]
  • [ 84057-84-1 ]
  • 2
  • [ 66387-70-0 ]
  • [ 84057-84-1 ]
  • 3-[5-amino-6-(2,3-dichloro-phenyl)-[1,2,4]triazin-3-yl]-6-bromo-2-phenyl-3H-quinazolin-4-one [ No CAS ]
  • 3
  • [ 19165-25-4 ]
  • [ 84057-84-1 ]
  • 3-[5-amino-6-(2,3-dichloro-phenyl)-[1,2,4]triazin-3-yl]-6-bromo-2-methyl-3H-quinazolin-4-one [ No CAS ]
  • 4
  • [ 123-56-8 ]
  • [ 84057-84-1 ]
  • C9H7Cl2N5*C4H5NO2 [ No CAS ]
  • 5
  • [ 104405-59-6 ]
  • [ 151169-74-3 ]
  • [ 84057-84-1 ]
YieldReaction ConditionsOperation in experiment
87.4% With 2,6-iPr2C6H3NC(4-CH3OC6H4)NHPy; palladium dichloride; In N,N-dimethyl-formamide; at 90℃;Inert atmosphere; 2,3-Dichlorobenzeneboronic acid (0.95 g, 5 mmol), 3,5-diamino 6-bromo-1,2,4-triazine (0.95 g, 5 mmol), potassium phosphate (1.09 g, 3.44 mmol) ), PdCl 2 (0.05 g, 10%, w/w%), ligand L4 (0.040 g, 0.1 mmol) was added to a mixed solution of DMF (30 mL), the system was replaced with nitrogen 4 times, under nitrogen protection at 90 C reacted overnight. The reaction was completely detected by TLC, cooled to room temperature, filtered, and the filtrate was diluted with ethyl acetate (300 mL), and washed three times with water (100 mL), the organic phase was evaporated to remove solvent, and the residue was purified by flash column chromatography The triazine was 1.12 g, and the yield was 87.4%.
  • 6
  • C9H7Cl2N5*H2O4S [ No CAS ]
  • [ 84057-84-1 ]
YieldReaction ConditionsOperation in experiment
97% With sodium hydroxide; at 65℃; for 3h; Step 2 obtained condensate was added 50g 30% caustic soda, heated to 65 C for 3h,The temperature, crystallization, filtration, washing, drying 65g [84057-84-1]lamotrigine, a yield of 97.0%.
  • 7
  • [ 2905-60-4 ]
  • [ 84057-84-1 ]
  • 8
  • [ 50-45-3 ]
  • [ 84057-84-1 ]
  • 9
  • [ 366-18-7 ]
  • [ 84057-84-1 ]
  • C10H8N2*1.5C9H7Cl2N5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
In ethyl acetate; at 40℃; for 3h; Weigh the reactants [84057-84-1]Lamotrigine: 2,2'-bipyridine = 1: 2 mass ratio Feed. With the analytical balance were accurately weighed 1.6674g [84057-84-1]Lamotrigine and 3.3348g2,2'_ bipyridine in 25mL mold; with a measuring cylinder accurately measured lO.OmL ethyl acetate in 25mL mold, dubbed 500mg / ml suspension; [031] the mold connected to the constant temperature water bath, the reaction temperature of 40 C, open the magnetic stirrer, stirring under the reaction 3h; stirring stopped after the reaction solution, filter products dried at room temperature, the product that For eutectomy for lamotrazine. As shown in Figure 1 and Figure 2, XRD is not a new eutectic, DSC is not eutectic purity is very, there is no residue of two kinds of raw materials. Liquid chromatographic data show that eutectic [84057-84-1]lamotrigine: 2,2'_bipyridine = 1: 1.5. The solubility of the product in water was 1.38 mg / ml
  • 10
  • [ 121-33-5 ]
  • [ 84057-84-1 ]
  • lamotrigine [ No CAS ]
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