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Chemical Structure| 104405-59-6 Chemical Structure| 104405-59-6

Structure of 104405-59-6

Chemical Structure| 104405-59-6

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Product Details of [ 104405-59-6 ]

CAS No. :104405-59-6
Formula : C3H4BrN5
M.W : 190.00
SMILES Code : NC1=NC(N)=C(Br)N=N1

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 104405-59-6 ]

[ 104405-59-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 104405-59-6 ]
  • [ 151169-74-3 ]
  • [ 84057-84-1 ]
YieldReaction ConditionsOperation in experiment
87.4% With 2,6-iPr2C6H3NC(4-CH3OC6H4)NHPy; palladium dichloride; In N,N-dimethyl-formamide; at 90℃;Inert atmosphere; 2,3-Dichlorobenzeneboronic acid (0.95 g, 5 mmol), 3,5-diamino 6-bromo-1,2,4-triazine (0.95 g, 5 mmol), potassium phosphate (1.09 g, 3.44 mmol) ), PdCl 2 (0.05 g, 10%, w/w%), ligand L4 (0.040 g, 0.1 mmol) was added to a mixed solution of DMF (30 mL), the system was replaced with nitrogen 4 times, under nitrogen protection at 90 C reacted overnight. The reaction was completely detected by TLC, cooled to room temperature, filtered, and the filtrate was diluted with ethyl acetate (300 mL), and washed three times with water (100 mL), the organic phase was evaporated to remove solvent, and the residue was purified by flash column chromatography The triazine was 1.12 g, and the yield was 87.4%.
 

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