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Chemical Structure| 84088-42-6 Chemical Structure| 84088-42-6

Structure of Roquinimex
CAS No.: 84088-42-6

Chemical Structure| 84088-42-6

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Roquinimex is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity and inhibits angiogenesis and reduces the secretion of TNF alpha.

Synonyms: Linomide; ABR212616; PNU 212616

4.5 *For Research Use Only !

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Product Details of Roquinimex

CAS No. :84088-42-6
Formula : C18H16N2O3
M.W : 308.33
SMILES Code : O=C(C1=C(O)C2=C(N(C)C1=O)C=CC=C2)N(C)C3=CC=CC=C3
Synonyms :
Linomide; ABR212616; PNU 212616
MDL No. :MFCD00866331
InChI Key :SGOOQMRIPALTEL-UHFFFAOYSA-N
Pubchem ID :54676478

Safety of Roquinimex

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P301+P310
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

Description
Roquinimex (Linomide; PNU212616; ABR212616) is a quinoline derivative immunostimulant that enhances NK cell activity and macrophage cytotoxicity, inhibits angiogenesis, and reduces TNF alpha secretion. Its IC50 value for TNF alpha is noteworthy. Prophylactic administration of roquinimex to DSS-treated mice significantly diminishes clinical signs of colitis, MDS, and CH-reduction. Additionally, in roquinimex-treated animals, MPO activity is notably reduced by over 50% compared to DSS control mice. Therapeutic administration of roquinimex in DSS-treated mice also significantly hampers MDS, CH-reduction, and MPO activity [2].

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.24mL

0.65mL

0.32mL

16.22mL

3.24mL

1.62mL

32.43mL

6.49mL

3.24mL

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