[ CAS No. 84388-68-1 ]

Name: 84388-68-1|4,5-Dichloro-2-hydroxybenzaldehyde|95+%
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SKU: A426968
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Product Details of [ 84388-68-1 ]

CAS No. :	84388-68-1	MDL No. :	MFCD06739497
Formula :	C₇H₄Cl₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	N/A
M.W :	191.01 g/mol	Pubchem ID :	-
Synonyms :

Safety of [ 84388-68-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P301+P312-P302+P352-P304+P340-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 84388-68-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 84388-68-1 ]

[ 84388-68-1 ] Synthesis Path-Downstream 1~32

1
[ 95-77-2 ]
[ 100-97-0 ]
[ 84388-68-1 ]

Yield	Reaction Conditions	Operation in experiment
58%	With methanesulfonic acid at 105℃; for 1h;	4,5-dichloro-2-hydroxybenzaldehyde (61b). To a solution of 3,4-dichlorophenol (7.5 g, 46.3 mmol) in methane sulfonic acid (45 mL) was added hexamethylenetetramine (7.14 g, 50.9 mmol) in small portions. The mixture was slowly heated to 105 °C and kept at 105 °C for 1 h before being cooled to room temperature and poured into ice-water. The mixture was extracted with EtOAc, and the extracts were combined, washed with brine, dried over Na2SO4, and recrystallized to give a yellow solid (5.1g, 58%).
23%	With methanesulfonic acid at 110℃; for 0.5h;	1.a Step a: To a stirred solution of 3,4-dichlorophenol (50.00 g, 306.75 mmol) in methanesulfonic acid (35 mL) was added hexamethyltetramine (47.50 g, 337.40 mmol) at room temperature. The reaction solution was stirred at 110 °C for 30 min. The reaction solution was allowed to cool down to room temperature and quenched with water (500 mL). The resulting solution was extracted with DCM (3 x 500 mL) and dried over anhydrous Na2SC>4. After the filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/DCM (10/1) to afford 4,5-dichloro-2- hydroxybenzaldehyde as a yellow solid (13.50 g, 23%): NMR (300 MHz, CDCh) d 10.96 (s, 1H), 9.84 (d, J= 0.7 Hz, 1H), 7.64 (s, 1H), 7.15 (s, 1H).
15%	Stage #1: 3,4-dichlorophenol; hexamethylenetetramine In trifluoroacetic acid Heating / reflux; Stage #2: With sulfuric acid In water; trifluoroacetic acid at 25℃; for 4h;	2 Example 1-3; Preparation of salicylaldehydes (27a, 27b, 28b) via formylation of 4-sabstituted phenoles (duff formylation); Preparation of 4,5-dichloro-2-hydroxy-benzaldehyde (27b) General procedure. To a solution of the appropriately substituted phenol (10.0 g) in TFA (100 mL) was added HMTA (1.1 equivalent) in small portions. The reaction solution was heated at reflux overnight. After cooling, the solution was treated with 50% H2SO4 solution (40 mL) for 4 h at room temperature, and then was extracted with ether (3?100 mL). The combined ether phases were washed with 5 M HCl solution and water, and then dried over anhydrous MgSO4. After filtration, the filtrate was evaporated and purified. 2-Hydroxy-5-trifluoromethyl-benzaldehyde (27a). Following the general procedure and FCC purification with 30% ethyl acetate-hexane, 4-trifluoromethyl phenol (10.0 g, 61.7 mmol) gave 2-hydroxy-5-trifluoromethyl-benzaldehyde 27 (3.9 g, 34%) as a pink solid. Rf (20% ethyl acetate-hexane): 0.47. 1H NMR (300 MHz, CDCl3) ? 11.31 (s, 1H, OH), 9.96 (s, 1H, CHO), 7.87 (d, J=1.6 Hz, 1H, C6-H (Ph)), 7.76 (dd, J=2.0 and 8.5 Hz, 1H, C4-H (Ph)) and 7.11 (d, J=8.8 Hz, 1H, C3-H (Ph)). 13C NMR (75 MHz, CDCl3) ? 195.8, 163.8, 133.4(d), 131.0(d), 125.3, 122.1 (m), 119.8 and 118.6. 4,5-Dichloro-2-hydroxy-benzaldehyde (27b) and 5,6-dichloro-2-hydroxy-benzaldehyde (28). Following the general procedure and FCC purification with 5-10% ethyl acetate-hexane, 3,4-dichlorophenol (10.0 g, 61.1 mmol) gave 5,6-dichloro-2-hydroxy-benzaldehyde 28 (2.2 g, 19%) as a light yellow solid. Rf (40% ethyl acetate-hexane): 0.63. 1H NMR (300 MHz, CDCl3) ? 11.98 (s, 1H, OH), 10.44 (s, 1H, CHO), 7.55 (d, J=9.4 Hz, 1H, C4-H (Ph)) and 6.89 (d, J=9.3 Hz, 1H, C3-H (Ph)). 13C NMR (75 MHz, CDCl3) ? 195.4, 162.4, 137.8 (2C), 135.6, 123.8 and 118.1. From the same reaction continuous FCC purification with 10% ethyl acetate-hexane gave 4,5-dichloro-2-hydroxy-benzaldehyde 27b (1.8 g, 15%) as a light yellow solid. Rf (40% ethyl acetate-hexane): 0.47. 1H NMR (300 MHz, CDCl3) ? 10.97 (s, 1H, OH), 9.84 (s, 1H, CHO), 7.64 (s, 1H, C3-H (Ph)) and 7.15 (s, 1H, C6-H (Ph)). 13C NMR (75 MHz, CDCl3) ? 194.7, 160.0, 149.9, 141.5, 134.0, 123.6 and 119.9.

18.2 g	With methanesulfonic acid at 105℃;
	In methanesulfonic acid at 105℃; for 0.25h;	33.A 4,5-Dichloro-2-hydroxybenzaldehyde 3,4-Dichlorophenol (20.0 g, 0.123 mol) was added to methylsulfonic acid (120 mL) and stirred for 15 min to give a clear solution. To this solution was added slowlyhexamethylenetetramine (18.8 g, 0.134 mol) in small portions. The mixture was then heated to 105 °C and stirred for 15 min before being cooled to room temperature and poured into a mixture of ice and water (1.2 L). The mixture was extracted with DCM (200 mL *3) and the combined extracts were dried over sodium sulfate and concentrated to give the subtitle intermediate as a crude yellow solid (18.2 g, 77%).

Reference： [1]Guo, Bin; Guo, Shimeng; Huang, Jing; Li, Jingya; Li, Jia; Chen, Qian; Zhou, Xianli; Xie, Xin; Yang, Yushe [Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 22, p. 5780 - 5791]
[2]Current Patent Assignee: D.E. SHAW RESEARCH LLC - WO2021/71821, 2021, A1 Location in patent: Paragraph 0232-0233
[3]Current Patent Assignee: NANOSHIFT - US2004/254103, 2004, A1 Location in patent: Page 9
[4]Cheng, Jianjun; Giguere, Patrick M.; Schmerberg, Claire M.; Pogorelov, Vladimir M.; Rodriguiz, Ramona M.; Huang, Xi-Ping; Zhu, Hu; McCorvy, John D.; Wetsel, William C.; Roth, Bryan L.; Kozikowski, Alan P. [Journal of Medicinal Chemistry, 2016, vol. 59, # 2, p. 578 - 591]
[5]Current Patent Assignee: UNIVERSITY OF ILLINOIS (SYSTEM) - WO2016/123164, 2016, A1 Location in patent: Paragraph 0273-0275

2
[ 1205681-42-0 ]
[ 84388-68-1 ]
[ 1205681-23-7 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: biphenyl-2-yl-carbamic acid 1-{2-[4-(2-amino-ethyl)-phenyl]-ethyl}-piperidin-4-yl ester; 4,5-dichloro-2-hydroxybenzaldehyde With acetic acid In ethanol for 1h; Stage #2: With sodium tris(acetoxy)borohydride In ethanol at 20℃; for 18h; Stage #3: With water In ethanol for 0.0833333h;	22 Example 22 Biphenyl-2-yl-carbamic acid 1-(2-{4-[2-(4,5-dichloro-2-hvdroxy-benzylamino)-ethyl1-phenyl)-ethvD- piperidin-4-yl ester; Biphenyl-2-yl-carbamic acid 1-{2-[4-(2-amino-ethyl)-phenyl]-ethyl}-piperidin-4-yl ester (Preparation 5, 40mg, 90μmol) was dissolved in ethanol (0.5ml) and added to a reaction vessel containing 4,5-dichloro-2- hydroxybenzaldehyde (17.2mg, 90μmol). To the reaction mixture was then added acetic acid (5.1 μl, 90μmol) and sodium sulphate (drying agent). The resulting mixture was allowed to stir for 1 hour. Sodium tri(acetoxy)borohydride (38mg, 178μmol) was then added, and the reaction allowed to stir at room temperature for 18h. The reaction was quenched with water (20μl) and stirred for 5 minutes. The solvents were removed in vacuo and the residue partitioned between dichloromethane (2ml) and saturated aqueous sodium hydrogen carbonate solution (2ml). The aqueous phase was separated and extracted with further dichloromethane (1 ml). The combined organic layers were concentrated in vacuo and the crude residue purified using an Isolute SCX-2 cartridge, eluting with methanol, followed by 1 M ammonia in methanol. The basic fractions were evaporated under reduced pressure and the residue purified by HPLC method E to afford the title compound. LCMS Method E: RT 2.27 min (100%area) ES m/z 618 [M+H]+.

Reference： [1]Current Patent Assignee: PFIZER INC - WO2010/7561, 2010, A1 Location in patent: Page/Page column 39-40

3
[ 1427594-56-6 ]
[ 84388-68-1 ]
[ 1427594-95-3 ]

Yield	Reaction Conditions	Operation in experiment
80.5%	With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃;	60 2-((4-(6-amino-5-(4-fluorophenyl)pyrimidin-4-yl)piperazin-1 -yl)methyl)-4₁5- dichlorophenol ("60") 2-((4-(6-amino-5-(4-fluorophenyl)pyrimidin-4-yl)piperazin-1 -yl)methyl)-415- dichlorophenol ("60")A reaction mixture of 5-(4-fluoro-phenyl)-6-piperazin-1 -yl-pyrimidin-4-ylamine (400.0 mg; 1 .46 mmol; 1 .00 eq.), 4,5-dichloro-2-hydroxy-benzaldehyde (279.5 mg; 1 .46 mmol; 1 .00 eq.), Acetic acid (87.8 mg; 1 .46 mmol; 1 .00 eq.) and sodium triacetoxy borohydride (926.1 mg; 4.39 mmol; 3.00 eq.) in DCE (1 0 ml ) was stirred overnight at RT. The reaction solution was diluted with DCM and washed with brine. The organic layer was dried and concentrated, which was added 10ml of ether and stirred for 5mins. The precipitate was filtered to afford the title asd white off solid (528mg, yield 80.5%). LC-MS: (M+1 =448, obsd. = 448/450).

Reference： [1]Current Patent Assignee: MERCK KGAA; LGOR MOCHALKIN - WO2013/40044, 2013, A1 Location in patent: Page/Page column 57

4
[ 141-97-9 ]
[ 84388-68-1 ]
[ 1087738-71-3 ]

Yield	Reaction Conditions	Operation in experiment
92%	With ziconium(IV) oxychloride octahydrate at 20℃; for 0.333333h; Milling; Green chemistry;

Reference： [1]Tasqeeruddin; Al-Arifi, Abdullah S.; Dubey [Asian Journal of Chemistry, 2013, vol. 25, # 12, p. 6885 - 6887]

5
[ 84388-68-1 ]
[ 105-53-3 ]
ethyl 6,7-dichloro-2-oxo-2H-chromene-3-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%	With ziconium(IV) oxychloride octahydrate at 20℃; for 0.666667h; Milling; Green chemistry;

Reference： [1]Tasqeeruddin; Al-Arifi, Abdullah S.; Dubey [Asian Journal of Chemistry, 2013, vol. 25, # 12, p. 6885 - 6887]

6
[ 84388-68-1 ]
[ 95-54-5 ]
C₂₀H₁₂Cl₄N₂O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With formaldehyd	EXPERIMENTAL General procedure: Modified salen ligands were synthesized by a single-step Mannich condensation between the phenylene diamine, ethylene diamine, formaldehyde and the substituted phenol. The synthesized salen compounds are shown in Scheme 1 the structures of synthetic compounds are confirmed with the spectroscopic data.

Reference： [1]Suh, Hyungsock; Song, Sanghoon; Ahn, Sunghyun; Kim, Taesoon; Kim, Beomsik; Chang, Taesun [Journal of the Korean Chemical Society, 2013, vol. 57, # 4, p. 525 - 528]

7
[ 84388-68-1 ]
[ 107-15-3 ]
C₁₆H₁₂Cl₄N₂O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With formaldehyd	EXPERIMENTAL General procedure: Modified salen ligands were synthesized by a single-step Mannich condensation between the phenylene diamine, ethylene diamine, formaldehyde and the substituted phenol. The synthesized salen compounds are shown in Scheme 1 the structures of synthetic compounds are confirmed with the spectroscopic data.

Reference： [1]Suh, Hyungsock; Song, Sanghoon; Ahn, Sunghyun; Kim, Taesoon; Kim, Beomsik; Chang, Taesun [Journal of the Korean Chemical Society, 2013, vol. 57, # 4, p. 525 - 528]

8
[ 14741-71-0 ]
[ 84388-68-1 ]
[ 1333341-00-6 ]

Reference： [1]Indian Journal of Heterocyclic Chemistry,2012,vol. 21,p. 289 - 292

9
3-ethyl-1-isopentyl-1,3,8-triazaspiro[4.5]decane-2,4-dione hydrochloride [ No CAS ]
[ 84388-68-1 ]
8-[(4,5-dichloro-2-hydroxyphenyl)methyl]-3-etyl-1-(3-methylbutyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
46.82%	Stage #1: 3-ethyl-1-isopentyl-1,3,8-triazaspiro[4.5]decane-2,4-dione hydrochloride; 4,5-dichloro-2-hydroxybenzaldehyde In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: With sodium tris(acetoxy)borohydride In N,N-dimethyl-formamide at 20℃; for 24h; Stage #3: With hydrogenchloride In diethyl ether	8-[(4,5-dichloro-2-hydroxyphenyl)methyl]-3-etyl-1-(3-methylbutyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione hydrochloride (12k) A mixture of 12n (30.3 mg, 0.10mmol, 1 equiv) and 4,5-dichloro-2-hydroxybenzaldehyde (38.2 mg, 0.20 mmol, 2 equiv) was dissolved in DMF (2 mL) and stirred at room temperature for 30 minutes before the addition of sodium triacetoxyborohydride (50.8 mg, 0.24 mmol, 2.4 equiv). The reaction stirred at room temperature under anhydrous conditions for 24 h. It was then quenched with water (1 mL) then purified by reverse phase HPLC (10% to 75% acetonitrile/water/0.05% TFA). The product was treated with 2 M HCl in diethyl either (0.1 mL) and stirred for 15 minutes before being filtered and dried to yield 66.7 mg product as a HCl salt. The solid was then dissolved in minimum amount of DCM and loaded onto an SCX column (2 g). The residual impurities were eluted with 1:1 MeOH/DCM (10 mL). The product was eluted with 2 M Ammonia/MeOH (10 mL). The ammonia eluent was then condensed yielding 30.2 mg final compound. The ammonia product was then condensed and dissolved in diethyl ether (1 mL). The product was then treated with 2M HCl in diethyl ether (0.05 mL) to make an HCl salt. The salt was filtered, yielding the final compound as an off white HCl salt (25.6 mg, 0.0532 mmol, 46.82% yield). 1H NMR (400 MHz,DMSO-d6) δ 7.42 (s, 1 H), 7.00 (s, 1 H), 3.66 (br. s., 1 H), 3.38 (q, J=7.2 Hz, 4 H), 3.09 - 3.25(m, 2 H), 2.78 (br. s., 4 H), 1.89 - 2.08 (m, 2 H), 1.69 (br. s., 2 H), 1.53 - 1.65 (m, 1 H), 1.34 -1.51 (m, 2 H), 1.07 (t, J=7.2 Hz, 3 H), 0.91 (d, J=6.6 Hz, 6 H). ES-MS m/z 443.84 (M+H).

Reference： [1]Meyers, Marvin J.; Anderson, Elizabeth J.; McNitt, Sarah A.; Krenning, Thomas M.; Singh, Megh; Xu, Jing; Zeng, Wentian; Qin, Limei; Xu, Wanwan; Zhao, Siting; Qin, Li; Eickhoff, Christopher S.; Oliva, Jonathan; Campbell, Mary A.; Arnett, Stacy D.; Prinsen, Michael J.; Griggs, David W.; Ruminski, Peter G.; Goldberg, Daniel E.; Ding, Ke; Liu, Xiaorong; Tu, Zhengchao; Tortorella, Micky D.; Sverdrup, Francis M.; Chen, Xiaoping [Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 16, p. 5144 - 5150]

10
[ 84388-68-1 ]
tert-butyl [[2-[2-(allyloxy)-4,5-dichlorophenyl]cyclopropyl]methyl]carbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 11 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux 8.1: triethylamine / dichloromethane / 0.5 h / 20 °C 9.1: boron tribromide / dichloromethane / 3 h / -78 °C / Inert atmosphere 10.1: triethylamine / dichloromethane / 0.5 h / 20 °C 11.1: caesium carbonate / N,N-dimethyl-formamide / 80 °C / Microwave irradiation

Reference： [1]Cheng, Jianjun; Giguere, Patrick M.; Schmerberg, Claire M.; Pogorelov, Vladimir M.; Rodriguiz, Ramona M.; Huang, Xi-Ping; Zhu, Hu; McCorvy, John D.; Wetsel, William C.; Roth, Bryan L.; Kozikowski, Alan P. [Journal of Medicinal Chemistry, 2016, vol. 59, # 2, p. 578 - 591]

11
[ 84388-68-1 ]
tert-butyl [[2-(4,5-dichloro-2-methoxyphenyl)cyclopropyl]methyl]carbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 9 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux 8.1: triethylamine / dichloromethane / 0.5 h / 20 °C 9.1: RegisPack chiral column / ethanol; hexane / Resolution of racemate

12
[ 84388-68-1 ]
tert-butyl [[2-(4,5-dichloro-2-methoxyphenyl)cyclopropyl]methyl]carbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 9 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux 8.1: triethylamine / dichloromethane / 0.5 h / 20 °C 9.1: RegisPack chiral column / ethanol; hexane / Resolution of racemate

13
[ 84388-68-1 ]
tert-butyl [[2-[4,5-dichloro-2-(2-fluoroethoxy)phenyl]cyclopropyl]methyl]carbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 12 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux 8.1: triethylamine / dichloromethane / 0.5 h / 20 °C 9.1: boron tribromide / dichloromethane / 3 h / -78 °C / Inert atmosphere 10.1: triethylamine / dichloromethane / 0.5 h / 20 °C 11.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 60 °C / Microwave irradiation 12.1: RegisPack chiral column / ethanol; hexane / Resolution of racemate

14
[ 84388-68-1 ]
tert-butyl [[2-[4,5-dichloro-2-(2-fluoroethoxy)phenyl]cyclopropyl]methyl]carbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 12 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux 8.1: triethylamine / dichloromethane / 0.5 h / 20 °C 9.1: boron tribromide / dichloromethane / 3 h / -78 °C / Inert atmosphere 10.1: triethylamine / dichloromethane / 0.5 h / 20 °C 11.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 60 °C / Microwave irradiation 12.1: RegisPack chiral column / ethanol; hexane / Resolution of racemate

15
[ 84388-68-1 ]
tert-butyl [[2-[2-(allyloxy)-4,5-dichlorophenyl]cyclopropyl]methyl]carbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 12 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux 8.1: triethylamine / dichloromethane / 0.5 h / 20 °C 9.1: boron tribromide / dichloromethane / 3 h / -78 °C / Inert atmosphere 10.1: triethylamine / dichloromethane / 0.5 h / 20 °C 11.1: caesium carbonate / N,N-dimethyl-formamide / 80 °C / Microwave irradiation 12.1: RegisPack chiral column / ethanol; hexane / Resolution of racemate

16
[ 84388-68-1 ]
tert-butyl [[2-[2-(allyloxy)-4,5-dichlorophenyl]cyclopropyl]methyl]carbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 12 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux 8.1: triethylamine / dichloromethane / 0.5 h / 20 °C 9.1: boron tribromide / dichloromethane / 3 h / -78 °C / Inert atmosphere 10.1: triethylamine / dichloromethane / 0.5 h / 20 °C 11.1: caesium carbonate / N,N-dimethyl-formamide / 80 °C / Microwave irradiation 12.1: RegisPack chiral column / ethanol; hexane / Resolution of racemate

17
[ 84388-68-1 ]
(-)-[2-(4,5-dichloro-2-methoxyphenyl)cyclopropyl]-methanamine hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 10 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux 8.1: triethylamine / dichloromethane / 0.5 h / 20 °C 9.1: RegisPack chiral column / ethanol; hexane / Resolution of racemate 10.1: hydrogenchloride / diethyl ether / 20 °C

18
[ 84388-68-1 ]
(+)-[2-(4,5-dichloro-2-methoxyphenyl)cyclopropyl]-methanamine hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 10 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux 8.1: triethylamine / dichloromethane / 0.5 h / 20 °C 9.1: RegisPack chiral column / ethanol; hexane / Resolution of racemate 10.1: hydrogenchloride / diethyl ether / 20 °C

19
[ 84388-68-1 ]
(-)-[2-[4,5-dichloro-2-(2-fluoroethoxy)phenyl]cyclopropyl]-methanamine hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 13 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux 8.1: triethylamine / dichloromethane / 0.5 h / 20 °C 9.1: boron tribromide / dichloromethane / 3 h / -78 °C / Inert atmosphere 10.1: triethylamine / dichloromethane / 0.5 h / 20 °C 11.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 60 °C / Microwave irradiation 12.1: RegisPack chiral column / ethanol; hexane / Resolution of racemate 13.1: hydrogenchloride / diethyl ether / 20 °C

20
[ 84388-68-1 ]
(+)-[2-[4,5-dichloro-2-(2-fluoroethoxy)phenyl]cyclopropyl]-methanamine hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 13 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux 8.1: triethylamine / dichloromethane / 0.5 h / 20 °C 9.1: boron tribromide / dichloromethane / 3 h / -78 °C / Inert atmosphere 10.1: triethylamine / dichloromethane / 0.5 h / 20 °C 11.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 60 °C / Microwave irradiation 12.1: RegisPack chiral column / ethanol; hexane / Resolution of racemate 13.1: hydrogenchloride / diethyl ether / 20 °C

21
[ 84388-68-1 ]
(E)-3-(4,5-dichloro-2-methoxyphenyl)-N-methoxy-N-methylacrylamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2: dichloromethane / 20 °C

22
[ 84388-68-1 ]
(-)-[2-[2-(allyloxy)-4,5-dichlorophenyl]cyclopropyl]-methanamine hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 13 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux 8.1: triethylamine / dichloromethane / 0.5 h / 20 °C 9.1: boron tribromide / dichloromethane / 3 h / -78 °C / Inert atmosphere 10.1: triethylamine / dichloromethane / 0.5 h / 20 °C 11.1: caesium carbonate / N,N-dimethyl-formamide / 80 °C / Microwave irradiation 12.1: RegisPack chiral column / ethanol; hexane / Resolution of racemate 13.1: hydrogenchloride / diethyl ether / 20 °C

23
[ 84388-68-1 ]
(+)-[2-[2-(allyloxy)-4,5-dichlorophenyl]cyclopropyl]-methanamine hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 13 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux 8.1: triethylamine / dichloromethane / 0.5 h / 20 °C 9.1: boron tribromide / dichloromethane / 3 h / -78 °C / Inert atmosphere 10.1: triethylamine / dichloromethane / 0.5 h / 20 °C 11.1: caesium carbonate / N,N-dimethyl-formamide / 80 °C / Microwave irradiation 12.1: RegisPack chiral column / ethanol; hexane / Resolution of racemate 13.1: hydrogenchloride / diethyl ether / 20 °C

24
[ 84388-68-1 ]
C₁₁H₁₀Cl₂O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere

25
[ 84388-68-1 ]
2-(4,5-dichloro-2-methoxyphenyl)-N-methoxy-N-methylcyclopropanecarboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C

26
[ 84388-68-1 ]
[2-(4,5-dichloro-2-methoxyphenyl)cyclopropyl]methanol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C

27
[ 84388-68-1 ]
2-[[2-(4,5-dichloro-2-methoxyphenyl)cyclopropyl]methyl]isoindoline-1,3-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

28
[ 84388-68-1 ]
C₁₁H₁₃Cl₂NO [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 7 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux

29
[ 84388-68-1 ]
(rac-trans)-tert-butyl ((2-(4,5-dichloro-2-methoxyphenyl)cyclopropyl)methyl)carbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 8 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux 8.1: triethylamine / dichloromethane / 0.5 h / 20 °C

30
[ 84388-68-1 ]
C₁₀H₁₁Cl₂NO [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 9 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux 8.1: triethylamine / dichloromethane / 0.5 h / 20 °C 9.1: boron tribromide / dichloromethane / 3 h / -78 °C / Inert atmosphere

31
[ 84388-68-1 ]
tert-butyl [[2-(4,5-dichloro-2-hydroxyphenyl)cyclopropyl]methyl]carbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 10 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux 8.1: triethylamine / dichloromethane / 0.5 h / 20 °C 9.1: boron tribromide / dichloromethane / 3 h / -78 °C / Inert atmosphere 10.1: triethylamine / dichloromethane / 0.5 h / 20 °C

32
[ 84388-68-1 ]
tert-butyl [[2-[4,5-dichloro-2-(2-fluoroethoxy)phenyl]cyclopropyl]methyl]carbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 11 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: dichloromethane / 20 °C 3.1: sodium hydride / dimethyl sulfoxide / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 0 - 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 7.1: hydrazine hydrate / ethanol / 3 h / Reflux 8.1: triethylamine / dichloromethane / 0.5 h / 20 °C 9.1: boron tribromide / dichloromethane / 3 h / -78 °C / Inert atmosphere 10.1: triethylamine / dichloromethane / 0.5 h / 20 °C 11.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 60 °C / Microwave irradiation

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
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P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
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P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
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P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
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P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
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P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
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P501	Dispose of contents/container to ...
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Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 84388-68-1 ]

Quality Control of [ 84388-68-1 ]

Related Doc. of [ 84388-68-1 ]

Product Details of [ 84388-68-1 ]

Safety of [ 84388-68-1 ]

Application In Synthesis of [ 84388-68-1 ]

[ 84388-68-1 ] Synthesis Path-Downstream 1~32

Related Functional Groups of [ 84388-68-1 ]

Chlorides

Aryls

Aldehydes

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 84388-68-1 ]