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Chemical Structure| 846023-47-0 Chemical Structure| 846023-47-0

Structure of 846023-47-0

Chemical Structure| 846023-47-0

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Product Details of [ 846023-47-0 ]

CAS No. :846023-47-0
Formula : C18H14Cl2FN3O3
M.W : 410.23
SMILES Code : O=C(NC1=CC(OC)=C(Cl)C=C1Cl)/C(C#N)=C/NC2=CC=C(OC)C(F)=C2
MDL No. :N/A

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Application In Synthesis of [ 846023-47-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 846023-47-0 ]

[ 846023-47-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 846023-24-3 ]
  • [ 366-99-4 ]
  • [ 122-51-0 ]
  • [ 846023-47-0 ]
YieldReaction ConditionsOperation in experiment
68% In isopropyl alcohol;Heating / reflux; EXAMPLE 15 3-Fluoro-4-methoxyanilino-N-(2,4-dichloro-5-methoxyphenyl)-2-cyano-2-propenamide To a suspension of <strong>[846023-24-3]2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide</strong> (1.00 g, 3.86 mmol) in 200 mL of isopropanol was added 3-fluoro-p-anisidine (0.60 g, 4.25 mmol). This mixture was heated to reflux to give a clear yellow solution. To this solution, triethylorthoformate (1.72 mL, 10.34 mmol) was added dropwise and the reaction mixture was heated at reflux overnight. An additional 2 mL of triethylorthoformate was added and the mixture was heated at reflux overnight. An additional 2 mL of triethylorthoformate was added and the mixture was heated at reflux overnight. The mixture was allowed to cool to room temperature and the white solid was collected by filtration, washed with isopropanol, and dried overnight at ~40 C. under reduced pressure. Purification by suspension in hot ethyl acetate followed by addition of cold hexanes gave 1.08 g (68%) of 3-fluoro-4-methoxyanilino-N-(2,4-dichloro-5-methoxyphenyl)-2-cyano-2-propenamide as a white solid, mp 275-276 C.; MS 408.1, 410.1 (M-H)- Analysis for C18H14Cl2FN3O3; Calcd: C, 52.70; H, 3.44; N, 10.24. Found: C, 52.44; H, 3.26; N, 10.14.
 

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