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Chemical Structure| 846035-55-0 Chemical Structure| 846035-55-0

Structure of 846035-55-0

Chemical Structure| 846035-55-0

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Product Details of [ 846035-55-0 ]

CAS No. :846035-55-0
Formula : C10H11FN2O
M.W : 194.21
SMILES Code : O=C1NC2=C(C=CC(F)=N2)C(C)(C)C1
MDL No. :MFCD18260324

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Application In Synthesis of [ 846035-55-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 846035-55-0 ]

[ 846035-55-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 618446-06-3 ]
  • [ 846035-55-0 ]
YieldReaction ConditionsOperation in experiment
92% With pyridine; hydrogen fluoride; sodium nitrite; In acetonitrile; at -42 - 0℃; for 2h; 7-Fluoro-4,4-dimethyI-3,4-dihydro-lH-[l,8]naphthyridin-2-one; 7-Fluoro-4,4-dimethyl-3,4-dihydro-lH-[l,8]naphthyridin-2-one, was produced as follows: HF-pyridine (100 mL) was cooled to -42 0C in a 1000 mL HDPE bottle using an CH3CN dry ice bath. While stirring vigorously, 7-amino-4,4-dimethyl-3,4- dihydro-lH-[l,8]naphthyridin-2-one (24.6 g, 0.129 mol) was added portionwise to control the exotherm. After the addition, NaNO2 (8.9 g, 0.1291 mol) was added portionwise. Significant exotherms were observed for both additions. The reaction mixture was then allowed to warm to 0 0C and stir for 2 h. The reaction mixture was quenched into a 4 L high density polyethylene (HDPE) bottle full of ice. The aqueous slurry was then neutralized using 2 N KOH. The resulting aqueous solution was extracted 3 times with CH2Cl2. The organic layers were dried over Na2SO4, filtered and concentrated to dryness. Excess pyridine was azeotroped with heptane. The product was dried under vacuum (2 mm Hg) for 3 h. The resulting product, 7-fluoro-4,4- dimethyl-3,4-dihydro-lH-[l,8]naphthyridin-2-one, was in the form of a white powder (23.06 g, 0.119 mol, 92%). MS: APCI: M+l: 195.1 (Exact Mass: 194.09).
 

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