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Chemical Structure| 847971-82-8 Chemical Structure| 847971-82-8

Structure of 847971-82-8

Chemical Structure| 847971-82-8

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Product Details of [ 847971-82-8 ]

CAS No. :847971-82-8
Formula : C17H20F3N3O2
M.W : 355.35
SMILES Code : O=C(N1CCN(C2=CC=C(C(F)(F)F)C=C2C#N)CC1)OC(C)(C)C
MDL No. :MFCD30498937

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Application In Synthesis of [ 847971-82-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 847971-82-8 ]

[ 847971-82-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1483-55-2 ]
  • [ 57260-71-6 ]
  • [ 847971-82-8 ]
YieldReaction ConditionsOperation in experiment
15% With sodium t-butanolate;tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; at 85℃; for 1h; Example 192: 4-Chloro-6-(2-piperazin-l-yl-5-trifluoromethyl-benzylamino)-2H- phthalazin-1-one; 4-(2-Cyano-4-tfluoromethyl-phenyl)-piperazine-l-carboxylic acid tert-butyl ester; A mixture of Boc-piperazine (573mg, (3.08 mmol), 2-bromo-5- trifluoromethylbenzonitrile (700mg, 2.80mmol), Pd2(dba)3 (256mg, 0.28 mmol), xantphos (486mg, 0.84mmol), sodium t-butoxide (660mg, 7.0mmol) in degassed anhydrous dioxane (1OmL) was heated at 85C for Ih. The mixture was allowed to cool and filtered through celite. The filtrate was concentrated and purified by chromatography (EtOAc/hexanes) to yield the title compound (150mg, 15%). m/z (M+ 1) 356.37.
 

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