Home Cart Sign in  
Chemical Structure| 848774-92-5 Chemical Structure| 848774-92-5

Structure of 848774-92-5

Chemical Structure| 848774-92-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 848774-92-5 ]

CAS No. :848774-92-5
Formula : C7H8N2
M.W : 120.15
SMILES Code : C=CC1=NN=C(C)C=C1
MDL No. :MFCD12828425

Safety of [ 848774-92-5 ]

Application In Synthesis of [ 848774-92-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 848774-92-5 ]

[ 848774-92-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 65202-58-6 ]
  • potassium vinyltrifluoroborate [ No CAS ]
  • [ 848774-92-5 ]
YieldReaction ConditionsOperation in experiment
With caesium carbonate;triphenylphosphine; palladium dichloride; In tetrahydrofuran; water; at 75 - 80℃; for 22h;Inert atmosphere; Potassium vinyltrifluoroborate (Aldrich, 1.71 g, 12.7 mmol), 3-bromo-6- methylpyridazine (Example 148A, 1.95 g, 11.3 mmol) and triphenylphosphine (0.18 g, 0.67 mmol) were added at room temperature to a solution Of Cs2CO3 (10.1 g, 31.0 mmol) in water (9.5 mL). Tetrahydrofuran (85 mL) was added, and the reaction flask was evacuated and purged with nitrogen (3 cycles). PdCl2 (50 mg, 0.28 mmol) was added, and the reaction flask was again evacuated and purged with nitrogen (3 cycles), then heated under nitrogen at 75-80 0C for 22 hours. The mixture was cooled to room temperature and the aqueous layer was separated and extracted with ethyl ether (3chi50 mL). The combined organic phase was concentrated to a volume of approximately 5 mL, and the residue was purified by flash chromatography (80 g silica, eluted with hexanes-ethyl acetate, 100:0 - 90:10): 1H NMR (300 MHz, methanol-^) delta ppm 2.71 (s, 3 H) 5.63 (d, J=I 1.2 Hz, 1 H) 6.18 (d, J=18.3 Hz, 1 H) 7.04 (dd, J=17.8, 11.0 Hz, 1 H) 7.23 - 7.34 (m, J=8.8 Hz, 1 H) 7.49 (d, J=8.8 Hz, 1 H).
 

Historical Records