Home Cart Sign in  
Chemical Structure| 857986-63-1 Chemical Structure| 857986-63-1

Structure of 857986-63-1

Chemical Structure| 857986-63-1

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 857986-63-1 ]

CAS No. :857986-63-1
Formula : C12H12N2O
M.W : 200.24
SMILES Code : O=C1N(C2=CC=CC=C2)NC(C3CC3)=C1
MDL No. :MFCD09028467

Safety of [ 857986-63-1 ]

Application In Synthesis of [ 857986-63-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 857986-63-1 ]

[ 857986-63-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 32249-35-7 ]
  • [ 857986-63-1 ]
YieldReaction ConditionsOperation in experiment
With phenylhydrazine; In acetic acid; at 120℃; Step A] 5-Cyclopropyl-2-phenyl-2,4-dihydro-pyrazol-3-one To a solution of methyl-3-cyclopropyl-3-oxopropionate (17 g) in acetic acid (40 mL) in a round bottom flask under argon was added phenylhydrazine (12.93 g). The mixture was immersed into an oil bath and heated to 120 C. overnight. The reaction vessel was then cooled and the acetic acid was evaporated in vacuo and the remaining solid was dissolved in EtOAc and water. The phases were separated and the aqueous phase was extracted with further EtOAc. The combined organic phases were washed with brine, dried over sodium sulfate, filtered and evaporated in vacuo and azeotroped with toluene (2*). The crude residue was then purified via trituration with a 1:1 mixture of ether/pentane to afford the desired 5-cyclopropyl-2-phenyl-2,4-dihydro-pyrazol-3-one (20.8 g) as a light brown solid. MS (ESI+):201.3 ([M+H]+).
 

Historical Records