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Chemical Structure| 862271-02-1 Chemical Structure| 862271-02-1

Structure of 862271-02-1

Chemical Structure| 862271-02-1

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Product Details of [ 862271-02-1 ]

CAS No. :862271-02-1
Formula : C14H12FNO4
M.W : 277.25
SMILES Code : O=[N+](C1=C(OCC2=CC=C(OC)C=C2)C=CC=C1F)[O-]
MDL No. :MFCD34563287

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Application In Synthesis of [ 862271-02-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 862271-02-1 ]

[ 862271-02-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 19064-24-5 ]
  • [ 862271-02-1 ]
YieldReaction ConditionsOperation in experiment
To a suspension of NaH (60% dispersion in mineral oil, 4.0 g, 100 mmol) in THF (200 mL) was added dropwise 4-methoxybenzyl alcohol (12 mL, 96.2 mmol) with stirring at 0 C. The mixture was stirred at room temperature for 15 min and <strong>[19064-24-5]2,6-difluoronitrobenzene</strong> (15.26 g, 100 mmol, Aldrich) was then added. The resulting red solution was heated to 65 C. with stirring and the progress of the reaction was monitored by TLC. The reaction mixture was cooled to room temperature and the solvent was removed in vacuo. The residue was dissolved in MeOH, evaporated onto SiO2 and eluted through a SiO2 plug with 25% EtOAc/hexane. Evaporation of the solvent under reduced pressure gave the crude product as a yellow amorphous solid, which was used in the next step without additional purification. MS (ESI, neg. ion.) m/z: 274.1 [M-1].
 

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