Home Cart 0 Sign in  

[ CAS No. 865187-82-2 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 865187-82-2
Chemical Structure| 865187-82-2
Structure of 865187-82-2 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 865187-82-2 ]

Related Doc. of [ 865187-82-2 ]

Alternatived Products of [ 865187-82-2 ]
Product Citations

Product Details of [ 865187-82-2 ]

CAS No. :865187-82-2 MDL No. :MFCD30292013
Formula : C7H8Br2S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 284.01 Pubchem ID :-
Synonyms :

Safety of [ 865187-82-2 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 865187-82-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 865187-82-2 ]
  • Downstream synthetic route of [ 865187-82-2 ]

[ 865187-82-2 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 865187-82-2 ]
  • [ 89-97-4 ]
  • [ 55142-85-3 ]
YieldReaction ConditionsOperation in experiment
78% With N-ethyl-N,N-diisopropylamine In acetonitrile at 5℃; for 5 h; Heating / reflux Example 24: Synthesis of 5-[(2-chlorophenyl) methyl] -4,5, 6,7- tetrahydrothieno [3,2-c] pyridine (compound of formula la; Ticlopidine); At below 5 °C, 5. 0 g of 2- (2-bromoethyl)-3-bromomethylthiophene obtained in Example 7 was dissolved in 50 mL of acetonitrile, and added thereto was a solution obtained by dissolving 2.7 g of 2-chlorobenzylamine and 6.8 g of diisopropylethylamine in 25 mL of acetonitrile. The resulting mixture was refluxed for 5 hours, and concentrated by evaporation under reduced pressure. The residue was dissolved in 100 mL of ethyl acetate, and washed twice with 70 mL portions of water. The organic layer was washed with 50 mL of saturated sodium chloride aqueous solution and concentrated under reduced pressure. The dark yellow colored oily residue thus obtained was subjected to a silica gel column chromatography (eluent, n-hexane: ethyl acetate = 5 : 1) to obtain 3.6 g (yield of 78percent) of the title compound as a yellowish oil. 'H-NMR (CDC13, ppm) : 6 2.87-2. 91 (m, 4H), 3.66 (s, 2H), 3.85 (s, 2H), 6.73 (d, 1H, J = 5.0 Hz), 7.09 (d, 1H, J = 0.5 Hz), 7.19-7. 29 (m, 2H), 7.35-7. 42 (m, 1H), 7. 52-7. 61 (m, 1H).
Reference: [1] Patent: WO2005/87779, 2005, A1, . Location in patent: Page/Page column 22-23
Recommend Products
Same Skeleton Products
Historical Records