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Chemical Structure| 872274-09-4 Chemical Structure| 872274-09-4

Structure of 872274-09-4

Chemical Structure| 872274-09-4

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Product Details of [ 872274-09-4 ]

CAS No. :872274-09-4
Formula : C7H4BrClO2
M.W : 235.46
SMILES Code : O=CC1=CC=C(Cl)C(Br)=C1O
MDL No. :MFCD23705580

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Application In Synthesis of [ 872274-09-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 872274-09-4 ]

[ 872274-09-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 67-66-3 ]
  • [ 855836-62-3 ]
  • [ 872274-09-4 ]
  • 3-bromo-2-chloro-4-hydroxy-benzaldehyde [ No CAS ]
  • 2
  • [ 50-00-0 ]
  • [ 855836-62-3 ]
  • [ 872274-09-4 ]
YieldReaction ConditionsOperation in experiment
97% With triethylamine; magnesium chloride; In tetrahydrofuran; at 90℃; for 12h; To a 500 mL three-necked flask was added tetrahydrofuran (250 mL), and anhydrous MgCl2 (9.2 g) was added under stirring.(96 mmol, 2 eq) and paraformaldehyde (4.3 g, 144 mmol, 3 eq), then triethylamine (9.7 g, 96 mmol, 2 eq) was added dropwise to the mixed suspension, and the mixture was stirred at room temperature for half an hour. To this was added <strong>[855836-62-3]2-bromo-3-chlorophenol</strong> (10.0 g, 48 mmol, leq), and the temperature was raised to 90 C. After stirring for 12 hours, the reaction solution was cooled to room temperature and diluted with 200 mL of water. Methyl tert-butyl ether was used for dilution. (100 mL) was extracted 3 times, and the layers were separated, and the organic layers were combined, washed once with 1 mol/L diluted hydrochloric acid, saturated sodium bicarbonate, and saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated to give 11 g of a yellow solid. Yield 97%, HPLC purity 98%.
 

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