[ CAS No. 875629-26-8 ] {[proInfo.proName]}

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2D 3D

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Quality Control of [ 875629-26-8 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 875629-26-8 ]

SDS Specification

Alternatived Products of [ 875629-26-8 ]

Product Details of [ 875629-26-8 ]

CAS No. :	875629-26-8	MDL No. :	MFCD11520621
Formula :	C₅H₉NO₂	Boiling Point :	No data available
Linear Structure Formula :	-	InChI Key :	OQTWISXQJKXTEM-UHFFFAOYSA-N
M.W :	115.13	Pubchem ID :	20653078
Synonyms :

Calculated chemistry of [ 875629-26-8 ] Expand+

Physicochemical Properties

Num. heavy atoms :	8
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.8
Num. rotatable bonds :	1
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	32.62
TPSA :	40.54 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-8.93 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.12
Log Po/w (XLOGP3) :	-2.71
Log Po/w (WLOGP) :	-0.75
Log Po/w (MLOGP) :	-0.38
Log Po/w (SILICOS-IT) :	-0.23
Consensus Log Po/w :	-0.59

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	1.22
Solubility :	1910.0 mg/ml ; 16.6 mol/l
Class :	Highly soluble
Log S (Ali) :	2.41
Solubility :	29600.0 mg/ml ; 257.0 mol/l
Class :	Highly soluble
Log S (SILICOS-IT) :	0.48
Solubility :	347.0 mg/ml ; 3.01 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.0

Safety of [ 875629-26-8 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P280-P305+P351+P338	UN#:
Hazard Statements:	H302-H315-H319-H332-H335	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 875629-26-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 875629-26-8 ]

[ 875629-26-8 ] Synthesis Path-Downstream 1~16

1
[ 875629-26-8 ]
[ 891270-42-1 ]
[ 891268-78-3 ]

Reference： [1]Journal of Medicinal Chemistry,2009,vol. 52,p. 3453 - 3456

2
[ 875629-26-8 ]
C₂₀H₂₅N₅O [ No CAS ]
[ 891266-24-3 ]

Reference： [1]Journal of Medicinal Chemistry,2009,vol. 52,p. 3453 - 3456

3
[ 50-00-0 ]
[ 36476-78-5 ]
[ 875629-26-8 ]

Yield	Reaction Conditions	Operation in experiment
94%	With hydrogen;palladium 10% on activated carbon; In methanol; water; under 3000.3 Torr;	EXAMPLE IX1-methyl-azetidine-3-carboxylic acid200 mg azetidine-3-carboxylic acid are dissolved in 10 ml of methanol, combined with 165 mul of a 37percent solution of formaldehyde in water as well as 20 mg 10percent palladium on charcoal and hydrogenated at 4 bar until the hydrogen uptake has ended.Then the catalyst is eliminated by suction filtering, the solvent is eliminated in vacuo, the residue is taken up in methanol and toluene and the solvents are again eliminated in vacuo.Yield: 214 mg (94percent of theory)Mass spectrum (ESI+): m/z=116 [M+H]+

Reference： [1]Patent: US2011/269737,2011,A1 .Location in patent: Page/Page column 44

4
[ 875629-26-8 ]
[ 1396776-39-8 ]
[ 1396776-23-0 ]

Yield	Reaction Conditions	Operation in experiment
		[0848] Synthesis of Compound B-8: N-((4,6-dimethyl-2-oxo-l,2-dihydropyridin-3- yl)methyl)- 1 -isopropyl-6-( 1 -( 1 -methylazetidine-3 -carbonyl)piperidin-4-yl)- 1 H- pyrazolo[3,4-b]pyridine-4-carboxamideCompound B-8[0849] Step 1 : Synthesis of N-((4,6-dimethyl-2-oxo-l ,2-dihydropyridin-3-yl)methyl)-l- isopropyl-6-( 1 -( 1 -methylazetidine-3-carbonyl)- 1 ,2,3 ,6-tetrahydropyridin-4-yl)- 1 H- pyrazolo [3 ,4-b]pyridine-4-carboxamide[0850] N-((4,6-dimethyl-2-oxo-l ,2-dihydropyridin-3-yl)methyl)-l-isopropyl-6-(l , 2,3,6- tetrahydropyridin-4-yl)-lH-pyrazolo[3,4-b]pyridine-4-carboxamide (1 equiv.) was dissolved in DMSO, to which Et3N (3 equiv.) and 1 -methylazetidine-3 -carboxylic acid (2 equiv.) was added. The reaction mixture was stirred at room temperature for 15 min before PYBOP (1.5 equiv.) was added to it and stirring was continued overnight. After completion of the reaction, water was added to it. Extraction was carried out using DCM; the combined organic layers were washed with water, brine and dried over anhydrous Na2S04; filtered and concentrated under reduced pressure to afford crude material which was purified by column chromatography to give the desired product.

Reference： [1]Patent: WO2012/118812,2012,A2 .Location in patent: Page/Page column 259-260

5
[ 875629-26-8 ]
5-phenyl-N-[trans-3-(hydrazinecarbonyl)cyclobutyl]isoxazole-3-carboxamide [ No CAS ]
5-phenyl-N-[trans-3-[[(1-methylazetidin-3-yl)formohydrazido]carbonyl]cyclobutyl]isoxazole-3-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%	With N-ethyl-N,N-diisopropylamine; HATU; In fluorobenzene; at 20.0℃; for 3h;	1 -methylazetidine-3 -carboxylic acid (172.5 mg, 1.50 mmol, 1.50 eq.), HATU (456 mg, 1.20 mmol, 1.20 eq.) andDIEA (387 mg, 2.99 mmol, 3.00 eq.) were added to a solution of 5-phenyl-N-trans-3- (hydrazinecarbonyl)cyclobutyl]isoxazole-3-carboxamide (300 mg, 1.00 mmol, 1.00 eq., prepared according to example 20) in DMF (15 mL). The resulting solution was stirred for 3 hours at room temperature and then it was concentrated under vacuum. The crude product waspurified by Flash-Prep-HPLC with the following conditions (IntelFlash-1): Column, C18; mobile phase, MeCN/H20 = 5:95 increasing to MeCN/H20 = 95:5 within 15 mm; Detector, UV 254 nm. This resulted in 337 mg (85percent) of 5-phenyl-N-[trans-3-[[(1-methylazetidin-3- yl)formohydrazido]carbonyl]cyclobutyl] isoxazole-3 -carboxamide as a yellow solid. LC-MS (ES, mlz): [M+H] = 398.

Reference： [1]Patent: WO2015/196071,A1 .Location in patent: Paragraph 0515
Patent: ,2015, .Location in patent: Paragraph 0515

6
[ 875629-26-8 ]
5-phenyl-N-[trans-3-(hydrazinecarbonyl)cyclobutyl]isoxazole-3-carboxamide [ No CAS ]
5-phenyl-N-[trans-3-[5-(1-methylazetidin-3-yl)-1,3,4-oxadiazol-2-yl]cyclobutyl]isoxazole-3-carboxamide [ No CAS ]

Reference： [1]Patent: WO2015/196071,A1
Patent: ,2015,

7
[ 875629-26-8 ]
3-phenyl-N-[trans-3-(hydrazinecarbonyl)cyclobutyl]isoxazole-5-carboxamide [ No CAS ]
3-phenyl-N-[trans-3-[[(1-methylazetidin-3-yl)formohydrazido]carbonyl]cyclobutyl]isoxazole-5-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
50%	With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20.0℃; for 2h;	1 -methylazetidine-3- carboxylic acid (172.5 mg, 1.50 mmol, 1.50 eq.), HATU (570 mg, 1.50 mmol, 1.50 eq.) and DIEA (387 mg, 2.99 mmol, 3.00 eq.) were added to a solution of 3-phenyl-N-[trans-3- (hydrazinecarbonyl)cyclobutyl]-isoxazole-5-carboxamide (300 mg, 1.00 mmol, 1.00 eq.) in DMF (10 mL) and then stirred for 2 hours at room temperature. The crude product was purified by Flash-Prep-HPLC with the following conditions (IntelFlash-1): Column, C I 8; mobile phase, MeCN/H20 = 5:95 increasing to MeCN/H20 = 95:5 within 30 min; Detector, UV 254 nm to give 200 mg (50percent) of 3-phenyl-N-[/ra5-3-[[(l -methylazetidin-3- yl)formohydrazido]carbonyl]cyclobutyl]-isoxazole-5-carboxamide as an off-white solid; LC- MS (ES, m/z): [M+H]+ = 398.0.

Reference： [1]Patent: WO2016/105485,2016,A2 .Location in patent: Paragraph 0187

8
[ 875629-26-8 ]
3-phenyl-N-[trans-3-(hydrazinecarbonyl)cyclobutyl]isoxazole-5-carboxamide [ No CAS ]
3-phenyl-N-[trans-3-[[(1-methylazetidin-3-yl)formohydrazido]carbonyl]cyclobutyl]-isoxazole-5-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
50%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20.0℃; for 2h;	1 -methylazetidine-3 - carboxylic acid (172.5 mg, 1.50 mmol, 1.50 eq.), HATU (570 mg, 1.50 mmol, 1.50 eq.) and DIEA (387 mg, 2.99 mmol, 3.00 eq.) were added to a solution of 3-phenyl-N-[trans-3- (hydrazinecarbonyl)cyclobutylj -isoxazole-5 -carboxamide (300 mg, 1.00 mmol, 1.00 eq.) inDMF (10 mL) and then stirred for 2 hours at room temperature. The crude product was purified by Flash-Prep-HPLC with the following conditions (IntelFlash-1): Column, C18; mobile phase, MeCN/H20 = 5:95 increasing to MeCN/H20 = 95:5 within 30 mm; Detector, UV 254 nm to give 200 mg (50percent) of 3-phenyl-N-[trans-3-[[(1-methylazetidin-3- yl)formohydrazidoj carbonyll cyclobutyll -isoxazole-5-carboxamide as an off-white solid; LC20 MS (ES, m/z): [M+Hj = 398.0.
50%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20.0℃; for 2h;	1 -methylazetidine-3 -carboxylic acid (172.5 mg, 1.50 mmol, 1.50 eq.), HATU (570 mg, 1.50 mmol, 1.50 eq.) andDIEA (387 mg, 2.99 mmol, 3.00 eq.) were added to a solution of 3-phenyl-N-[trans-3-(hydrazinecarbonyl)cyclobutylj -isoxazole-5 -carboxamide (300 mg, 1.00 mmol, 1.00 eq.) inDMF (10 mL) and then stirred for 2 hours at room temperature. The crude product waspurified by Flash-Prep-HPLC with the following conditions (IntelFlash-1): Column, C18;mobile phase, MeCN/H20 = 5:95 increasing to MeCN/H20 = 95:5 within 30 mm; Detector,UV 254 nm to give 200 mg (50percent) of 3-phenyl-N-[trans-3-[[(1-methylazetidin-3- yl)formohydrazidoj carbonyll cyclobutyll -isoxazole-5-carboxamide as an off-white solid; LCMS (ES, m/z): [M+Hj = 398.0.

Reference： [1]Patent: WO2017/19589,2017,A1 .Location in patent: Paragraph 0161
[2]Patent: WO2017/112853,2017,A1 .Location in patent: Paragraph 0161

9
[ 875629-26-8 ]
3-phenyl-N-[trans-3-(hydrazinecarbonyl)cyclobutyl]isoxazole-5-carboxamide [ No CAS ]
3-phenyl-N-[trans-3-[5-(1-methylazetidin-3-yl)-1,3,4-oxadiazol-2-yl]cyclobutyl]isoxazole-5-carboxamide [ No CAS ]

Reference： [1]Patent: WO2017/19589,2017,A1

10
[ 875629-26-8 ]
5-phenyl-N-[trans-3-(hydrazinecarbonyl)cyclobutyl]isoxazole-3-carboxamide [ No CAS ]
5-phenyl-N-[trans-3-[[(1-methylazetidin-3-yl)formohydrazido]carbonyl]cyclobutyl]isoxazole-3-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%	With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20.0℃; for 3h;	l-methylazetidine-3- carboxylic acid (172.5 mg, 1.50 mmol, 1.50 eq.), HATU (456 mg, 1.20 mmol, 1.20 eq.) and DIEA (387 mg, 2.99 mmol, 3.00 eq.) were added to a solution of (hydrazinecarbonyl)cyclobutyl]isoxazole-3-carboxamide (300 mg, 1.00 mmol, 1.00 eq., prepared according to example 20) in DMF (15 mL). The resulting solution was stirred for 3 hours at room temperature and then it was concentrated under vacuum. The crude product was purified by Flash-Prep-HPLC with the following conditions (IntelFlash-1): Column, CI 8; mobile phase, MeCN/H20 = 5:95 increasing to MeCN/H20 = 95:5 within 15 min; Detector, UV 254 nm. This resulted in 337 mg (85percent) of 5-phenyl-N-[fras-3-[[(l-methylazetidin-3- yl)formohydrazido]carbonyl]cyclobutyl]isoxazole-3-carboxamide as a yellow solid. LC-MS (ES, m/z): [M+H]+ = 398.

Reference： [1]Patent: WO2017/40606,2017,A1 .Location in patent: Paragraph 0460

11
[ 875629-26-8 ]
5-phenyl-N-[trans-3-(hydrazinecarbonyl)cyclobutyl]isoxazole-3-carboxamide [ No CAS ]
5-phenyl-N-[trans-3-[5-(1-methylazetidin-3-yl)-1,3,4-oxadiazol-2-yl]cyclobutyl]isoxazole-3-carboxamide [ No CAS ]

Reference： [1]Patent: WO2017/40606,2017,A1

12
[ 875629-26-8 ]
2-(4-aminophenyl)-3-(pyridin-3-yl)quinazolin-4(3H)-one dihydrochloride [ No CAS ]
N-(4-(3,4-dihydro-4-oxo-3-(pyridin-3-yl)quinazolin-2-yl)phenyl)-1-methylazetidine-3-carboxamide dihydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
10 mg		A mixture of 2-(4-aminophenyl)-3-(pyridin-3-yl)quinazolin-4(3H)-one hydrochloride (50 mg, 0.13 mmol), l-methylazetidine-3-carboxylic acid (41 uL, 0.33 mmol), (1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate) (162 mg, 0.42mmol), diisopropylethyl amine ( 0.15 mL, 0.7 mmol) in dimethylformamide (1 mL) was stirred for 18 hours. The reaction was filtered and then purified by reverse phase -HPLC (3-35percent acetonitrile /water) to give the title compound (23 mg). The sample was converted to an HCl salt with 4N HCl in dioxane (10 mg). LC/MS: RT = 2.76 minutes, purity > 95percent, (M+l)+ = 412.02. NMR (300MHz, CD3OD) delta = 8.53 (d, /=8.2 Hz, 1H), 8.46 - 8.30 (m, 1H), 8.17 - 7.92 (m, 3H), 7.92 - 7.81 (m, 1H), 7.81 - 7.65 (m, 3H), 7.58 - 7.42 (m, 2H), 4.62 - 4.39 (m, 2H), 4.30 - 4.05 (m, 2H), 3.92 - 3.69 (m, 1H), 3.02 - 2.85 (m, 4H), 1.41 - 1.21 (m, 1H)

Reference： [1]Patent: WO2018/118791,2018,A2 .Location in patent: Paragraph 0195

13
[ 875629-26-8 ]
2-(4-aminophenyl)thieno[3,2-d]pyrimidin-4(3H)-one hydrochloride [ No CAS ]
N-(4-(3,4-dihydro-4-oxothieno[3,2-d]pyrimidin-2-yl)phenyl)-1-methyl azetidine-3-carboxamide hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
12 mg		A mixture of 2-(4-aminophenyl)thieno[3,2-d]pyrirnidin-4(3H)-one hydrochloride (43 mg, 0.15 mmol), diisopropylethyl amine (0.15 mL), (l-[bis(dimethylamino)methylene]-l.H-l ,2,3-triazoo[4,5- b]pyridinium 3-oxid hexafluorophosphate) (134 mg, 0.35 mmol), l-methylazetidine-3-carboxylic acid (36 mg, 0.31 mmol) and dimethylformamide (2 mL) was stirred for 18 hours. The reaction was filtered and then purified by reverse phase HPLC (3-35percent acetonitrile/water). To the product (26 mg) in ethyl acetate/methanol was added 4N HC1 in dioxane. The mixture was stirred 30 mins. The solid was collected by filtration, washed with ethyl acetate and dried to give the desired HC1 salt (12 mg). LC/MS: RT = 2.59 minutes, purity > 95percent, (M+l)+ = 341.02.)

Reference： [1]Patent: WO2018/118791,2018,A2 .Location in patent: Paragraph 0200

14
[ 875629-26-8 ]
5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-(((1S,2S,4S)-2-(methylamino)-4-(3-(trifluoromethyl)phenyl)cyclohexyl)amino)-N-(pyrimidin-4-yl)benzenesulfonamide [ No CAS ]
N-((1S,2S,5S)-2-((2-chloro-4-(N-(2,4-dimethoxybenzyl)-N-(pyrimidin-4-yl)sulfamoyl)-5-fluorophenyl)amino)-5-(3-(trifluoromethyl)phenyl)cyclohexyl)-N,1-dimethylazetidine-3-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20.0℃; for 18h;	[0377] To 5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-(((1S,2S,4S)-2-(methylamino)-4-(3-(trifluoromethyl)-phenyl)cyclohexyl)amino)-N-(pyrimidin-4-yl)benzenesulfonamide (20 mg, 0.03 mmol) in DMF (0.3 mL) was added <strong>[875629-26-8]1-methylazetidine-3-carboxylic acid</strong> (5 mg, 0.04 mmol) followed by N,N-diisopropylethylamine (20 uL, 0.11 mmol) and HATU (13 mg, 0.03 mmol). The reaction mixture was stirred at room temperature for 18 hours then diluted with water and EtOAc. The organic layer was separated and washed with saturated aqueous NaHCO3, then aqueous saturated brine solution, dried over Na2SO4, filtered and concentrated to provide N-((1S,2S,5S)-2-((2-chloro-4-(N-(2,4-dimethoxybenzyl)-N-(pyrimidin-4-yl)sulfamoyl)-5-fluorophenyl)amino)-5-(3-(trifluoromethyl)phenyl)cyclohexyl)-N,1-dimethylazetidine-3-carboxamide which was used directly in the next step without further purification.

Reference： [1]Patent: US2019/263786,2019,A1 .Location in patent: Paragraph 0377-0378

15
[ 875629-26-8 ]
2-((2-ethyl-7-methyl-5-(6-(1-methylazetidine-3-carbonyl)-2,6-diazaspiro[3.4]octan-2-yl)pyrazolo[1,5-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		Example 47 2-((2-ethyl-7-methyl-5-(6-(1-methylazetidine-3-carbonyl)-2,6-diazaspiro[3.4]octan-2-yl)pyrazolo[1,5-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile (Compound 47) Compound 47 was prepared from 44b and <strong>[875629-26-8]1-methylazetidine-3-carboxylic acid</strong> in a manner analogous to Example 31. 1H NMR (400 MHz, CDCl3) delta 8.15 (dd, J=8.6, 5.5 Hz, 2H), 7.15 (t, J=8.6 Hz, 2H), 5.97 (s, 1H), 5.83 (d, J=2.6 Hz, 1H), 3.91-3.81 (m, 6H), 3.69 (s, 1H), 3.56 (t, J=5.9 Hz, 6H), 3.48-3.40 (m, 3H), 2.78-2.71 (m, 2H), 2.69 (d, J=2.1 Hz, 3H), 2.45 (d, J=4.1 Hz, 3H), 2.24 (t, J=6.9 Hz, 1H), 2.14 (t, J=7.0 Hz, 1H), 1.35-1.28 (m, 3H). LC-MS (ESI): m/z=599.3 [M+H]+

Reference： [1]Patent: US2019/367515,2019,A1

16
[ 875629-26-8 ]
2-((2-cyclopropyl-7-methyl-5-(6-(1-methylazetidine-3-carbonyl)-2,6-diazaspiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		Example 84 2-((2-cyclopropyl-7-methyl-5-(6-(1-methylazetidine-3-carbonyl)-2,6-diazaspiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile (Compound 84) The title compound was prepared by the method substantially similar to that mentioned in Step 3 (Example 77), using <strong>[875629-26-8]1-methylazetidine-3-carboxylic acid</strong> afford Compound 84 as a yellow solid. 1H NMR (400 MHz, CDCl3) delta 8.21-8.11 (m, 2H), 7.16 (t, 2H), 5.92 (s, 1H), 5.81 (d, 1H), 4.27 (s, 2H), 4.18 (s, 2H), 4.10-3.98 (m, 4H), 3.89 (t, 2H), 3.61 (s, 3H), 3.44 (dt, 3H), 2.62 (s, 3H), 2.50 (s, 3H), 1.93-1.78 (m, 1H), 1.12-0.88 (m, 4H). LC-Ms m/z (ESI): 597.3[M+H+]

Reference： [1]Patent: US2019/367515,2019,A1

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Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 875629-26-8 ] {[proInfo.proName]}

Quality Control of [ 875629-26-8 ]

Related Doc. of [ 875629-26-8 ]

Product Details of [ 875629-26-8 ]

Calculated chemistry of [ 875629-26-8 ] Expand+

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 875629-26-8 ]

Application In Synthesis of [ 875629-26-8 ]

[ 875629-26-8 ] Synthesis Path-Downstream 1~16

Technical Information

Related Functional Groups of [ 875629-26-8 ]

Carboxylic Acids

Related Parent Nucleus of [ 875629-26-8 ]

Aliphatic Heterocycles

Azetidines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 875629-26-8 ]

Related Parent Nucleus of
[ 875629-26-8 ]