[ CAS No. 877773-38-1 ] {[proInfo.proName]}

Name: 877773-38-1|(2S,6S)-2,6-Di-tert-butyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole|98%
Brand: Ambeed
SKU: A648738
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Quality Control of [ 877773-38-1 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 877773-38-1 ]

Product Details of [ 877773-38-1 ]

CAS No. :	877773-38-1	MDL No. :	MFCD22690898
Formula :	C₁₃H₂₅N₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	NHPAGFYCHIPMCC-NXEZZACHSA-N
M.W :	223.36	Pubchem ID :	24746352
Synonyms :

Safety of [ 877773-38-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 877773-38-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 877773-38-1 ]

[ 877773-38-1 ] Synthesis Path-Downstream 1~10

1
[ 1430732-10-7 ]
[ 2314-48-9 ]
[ 877773-38-1 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: (S)-N¹-((S)-2-Amino-3,3-dimethyl-butyl)-3,3-dimethyl-butane-1,2-diamine; (S,S)-dimethyl trithiocarbonate In nitromethane at 110℃; for 2h; Stage #2: With acetic acid; methyl iodide In nitromethane at 110℃; for 3h;

Reference： [1]Ye, Weiping; Leow, Dasheng; Goh, Serena Li Min; Tan, Chin-Tong; Chian, Chee-Hoe; Tan, Choon-Hong [Tetrahedron Letters, 2006, vol. 47, # 6, p. 1007 - 1010]

2
[ 1629375-12-7 ]
[ 877773-38-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: acetonitrile / 72 h / 95 °C 2.1: sodium / liquid ammonia; tetrahydrofuran / -78 °C 3.1: nitromethane / 2 h / 110 °C 3.2: MeI; acetic acid / nitromethane / 3 h / 110 °C

Reference： [1]Ye, Weiping; Leow, Dasheng; Goh, Serena Li Min; Tan, Chin-Tong; Chian, Chee-Hoe; Tan, Choon-Hong [Tetrahedron Letters, 2006, vol. 47, # 6, p. 1007 - 1010]

3
[ 877773-35-8 ]
[ 877773-38-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: sodium / liquid ammonia; tetrahydrofuran / -78 °C 2.1: nitromethane / 2 h / 110 °C 2.2: MeI; acetic acid / nitromethane / 3 h / 110 °C

Reference： [1]Ye, Weiping; Leow, Dasheng; Goh, Serena Li Min; Tan, Chin-Tong; Chian, Chee-Hoe; Tan, Choon-Hong [Tetrahedron Letters, 2006, vol. 47, # 6, p. 1007 - 1010]

4
[ 112245-13-3 ]
[ 877773-38-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: Et₃N; 4 Angstroem molecular sieves / acetonitrile / 1.33 h / 0 - 20 °C 1.2: 80 percent / Et₃N; DMAP; MsCl / CH₂Cl₂ / 3 h / 20 °C 2.1: acetonitrile / 72 h / 95 °C 3.1: sodium / liquid ammonia; tetrahydrofuran / -78 °C 4.1: nitromethane / 2 h / 110 °C 4.2: MeI; acetic acid / nitromethane / 3 h / 110 °C
	Multi-step reaction with 5 steps 1.1: Et₃N; 4 Angstroem molecular sieves / acetonitrile / 1.33 h / 0 - 20 °C 1.2: 80 percent / Et₃N; DMAP; MsCl / CH₂Cl₂ / 3 h / 20 °C 2.1: NH₃ / methanol / 0 - 20 °C 3.1: acetonitrile / 72 h / 95 °C 4.1: sodium / liquid ammonia; tetrahydrofuran / -78 °C 5.1: nitromethane / 2 h / 110 °C 5.2: MeI; acetic acid / nitromethane / 3 h / 110 °C

Reference： [1]Ye, Weiping; Leow, Dasheng; Goh, Serena Li Min; Tan, Chin-Tong; Chian, Chee-Hoe; Tan, Choon-Hong [Tetrahedron Letters, 2006, vol. 47, # 6, p. 1007 - 1010]
[2]Ye, Weiping; Leow, Dasheng; Goh, Serena Li Min; Tan, Chin-Tong; Chian, Chee-Hoe; Tan, Choon-Hong [Tetrahedron Letters, 2006, vol. 47, # 6, p. 1007 - 1010]

5
[ CAS Unavailable ]
[ 877773-38-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: acetonitrile / 72 h / 95 °C 2.1: sodium / liquid ammonia; tetrahydrofuran / -78 °C 3.1: nitromethane / 2 h / 110 °C 3.2: MeI; acetic acid / nitromethane / 3 h / 110 °C
	Multi-step reaction with 4 steps 1.1: NH₃ / methanol / 0 - 20 °C 2.1: acetonitrile / 72 h / 95 °C 3.1: sodium / liquid ammonia; tetrahydrofuran / -78 °C 4.1: nitromethane / 2 h / 110 °C 4.2: MeI; acetic acid / nitromethane / 3 h / 110 °C

6
[ 877773-38-1 ]
[ CAS Unavailable ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
	In dichloromethane at 20℃; Glovebox; Inert atmosphere;

Reference： [1]Ge, Yicen; Cui, Xi-Yang; Tan, Siu Min; Jiang, Huan; Ren, Jingyun; Lee, Nicholas; Lee, Richmond; Tan, Choon-Hong [Angewandte Chemie - International Edition, 2019, vol. 58, # 8, p. 2382 - 2386][Angew. Chem., 2019, vol. 131, # 8, p. 2404 - 2408,5]

7
[ 877773-38-1 ]
[ CAS Unavailable ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate In chloroform at 20℃;

8
[ 877773-38-1 ]
[ 333-27-7 ]
[ 2271289-27-9 ]

Yield	Reaction Conditions	Operation in experiment
67%	Stage #1: 2,6-di-<i>tert</i>-butyl-2,3,5,6-tetrahydro-1<i>H</i>-imidazo[1,2-<i>a</i>]imidazole; methyl trifluoromethanesulfonate In dichloromethane for 8h; Glovebox; Inert atmosphere; Stage #2: With potassium carbonate In dichloromethane Glovebox; Inert atmosphere;

9
[ 877773-38-1 ]
[ 626-15-3 ]
[ 2271289-32-6 ]

Yield	Reaction Conditions	Operation in experiment
33%	In tetrahydrofuran Schlenk technique; Reflux;

10
[ 2230289-43-5 ]
[ 877773-38-1 ]

Yield	Reaction Conditions	Operation in experiment
33%	With potassium carbonate In dichloromethane

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P321
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P342	If experiencing respiratory symptoms:
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P351	Rinse cautiously with water for several minutes.
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P353	Rinse skin with water/shower.
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P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
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P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
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H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
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H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 877773-38-1 ] {[proInfo.proName]}

Quality Control of [ 877773-38-1 ]

Related Doc. of [ 877773-38-1 ]

Product Details of [ 877773-38-1 ]

Safety of [ 877773-38-1 ]

Application In Synthesis of [ 877773-38-1 ]

[ 877773-38-1 ] Synthesis Path-Downstream 1~10

Precautionary Statements-General

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