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Chemical Structure| 879883-54-2 Chemical Structure| 879883-54-2

Structure of 879883-54-2

Chemical Structure| 879883-54-2

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Product Details of [ 879883-54-2 ]

CAS No. :879883-54-2
Formula : C16H30N2O2
M.W : 282.42
SMILES Code : O=C(N1CCC(CC2CCNCC2)CC1)OC(C)(C)C
MDL No. :MFCD15474945
InChI Key :JFKOSNRSLHVFMJ-UHFFFAOYSA-N
Pubchem ID :49761197

Safety of [ 879883-54-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

Application In Synthesis of [ 879883-54-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 879883-54-2 ]

[ 879883-54-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 879883-54-2 ]
  • [ 85953-29-3 ]
  • tert-butyl 4-((1-(3-chloro-4-(methoxycarbonyl)phenyl)piperidin-4-yl)methyl)piperidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
578 mg With caesium carbonate; In dimethyl sulfoxide; at 120℃; for 1.0h;Inert atmosphere; Microwave irradiation; Step 1 : tert-butyl 4-((l-(3-chloro-4-(methoxycarbonyl)phenyl)piperidin-4-yl)methyl)piperidine- 1-carboxylate A mixture of <strong>[85953-29-3]methyl 2-chloro-4-fluorobenzoate</strong> (367 mg, 1.95 mmol), tert-butyl 4-(piperidin-4- y lmethyl)piperi dine- 1-carboxy late (500 mg, 1.77 mmol), and CS2CO3 (1269 mg, 3.89 mmol) in DMSO (8.8 ml) was degassed by bubbling with N2 and heated at 120C for lh under microwave condition. The mixture was diluted with EtOAc-H20, and the aq. layer was extracted with EtOAc (3x). The combined organic fractions were dried over Na2SC>4, filtered and the solvent was evaporated under reduced pressure. The reaction mixture was purified by ISCO column chromatography (silica gel ISCO 40 g prepacked column, eluting with 0-100% EtOAc/Hexane) to give the title compound (578 mg). LCMS m/z (M+H): Calc'd 451.2, found 451.4.
 

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