Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

CAS No. :	88014-15-7
Formula :	C₁₁H₁₅NO
M.W :	177.24
SMILES Code :	OCCN1CC2=C(C=CC=C2)CC1
English Name :	2-(3,4-Dihydroisoquinolin-2(1H)-yl)ethanol
MDL No. :	MFCD08059809

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Yield	Reaction Conditions	Operation in experiment
	With hydrogen bromide
929 mg	With hydrogen bromide In water at 0 - 135℃; for 20h;

Yield	Reaction Conditions	Operation in experiment
62%	With sodium methylate; potassium iodide In methanol at 15℃; Electrochemical reaction;
	With mercury(II) diacetate In water; acetic acid at 60℃;

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CAS No.: 88014-15-7

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CAS No.: 88014-15-7

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[ 88014-15-7 ] Synthesis Path-Downstream 1~8

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Yield	Reaction Conditions	Operation in experiment
68%	With lithium aluminium tetrahydride In diethyl ether for 3h; Reflux;
54.5%	With lithium aluminium tetrahydride In diethyl ether for 3h; Heating;
	With sodium hydroxide; LiAlH₄ In tetrahydrofuran; dichloromethane; water	2-(2-hydroxyethyl)-1,2,3,4-tetrahydroisoquinoline 2-(2-hydroxyethyl)-1,2,3,4-tetrahydroisoquinoline 1.9 g (50.0 mmol) of LiAlH4 were suspended, under nitrogen atmosphere, in 100 ml of dry THF; the reaction mixture was cooled at 0° C. and 5.0 g (22.8 mmol) of 2-ethoxycarbonylmethyl-1,2,3,4-tetrahydroisoquinoline (compound of Description 14), dissolved in 100 ml of dry THF, were added dropwise. The reaction was stirred at room temperature for 2 hours, ice-cooled and quenched with 2.5 ml of H2O, 7.5 ml of 15% NaOH, 2.5 ml of H2O, stirred for 30 minutes and filtered. The filtrate was evaporated in vacuo to dryness, dissolved in CH2Cl2 and washed with sat. sol. NaCl. The organic layer was dried over Na2SO4 and evaporated in vacuo to dryness to yield 3.9 g of the title compound which was used without further purification.

Yield	Reaction Conditions	Operation in experiment
74%	With edetate disodium; mercury(II) oxide In ethanol; water Heating;
38%	With tetraethylammonium tosylate; phosphonic acid diethyl ester In dichloromethane at 20℃; for 6h; Electrolysis; Green chemistry;	2-Phenyl-3,4-dihydroisoquinolin-1(2H)-one (4a); Typical Procedure General procedure: A 10 mL distillation flask equipped with a magnetic stirring bar was charged with diethyl phosphite (42 mg, 0.3 mmol), wet CH2Cl2 (5.0 mL), 2-phenyl-1,2,3,4-tetrahydroisoquinoline 1a (52 mg, 0.25 mmol), and Et4NOTs (151 mg, 0.5 mmol). The resulting suspension was stirred until complete dissolution was achieved. The flask equipped with graphite rod anode (d = 5 mm) and Pt plate cathode (0.5×0.5 cm). The reaction mixture was stirred and electrolyzed at a constant current of 5 mA at rt for 9 h. The reaction mixture was diluted with CH2Cl2 (15 mL), washed successively with water (10 mL) and brine (10 mL), dried with Na2SO4, and concentrated in vacuo. Purification by flash column chromatography (silica gel, petroleum ether-ethyl acetate 20:1) afforded the desired product 4a 48 mg (86%) as a white solid;

Precautionary Statements-General
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P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
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P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
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P232	Protect from moisture.
P233	Keep container tightly closed.
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P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
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P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
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Code	Phrase
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P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
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P332	IF SKIN irritation occurs:
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P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
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P342	If experiencing respiratory symptoms:
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P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
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P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
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P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
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P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
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P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
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P337 + P313	IF eye irritation persists: Get medical advice/attention.
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Storage
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P401
P402	Store in a dry place.
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P411 + P235	Keep cool.
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Physical hazards
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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
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H222	Extremely flammable aerosol
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H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed