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Chemical Structure| 881995-73-9 Chemical Structure| 881995-73-9

Structure of 881995-73-9

Chemical Structure| 881995-73-9

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Product Details of [ 881995-73-9 ]

CAS No. :881995-73-9
Formula : C16H20F3NO4
M.W : 347.33
SMILES Code : O=C(OC)C[C@H](NC(OC(C)(C)C)=O)CC1=CC(F)=C(F)C=C1F

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Application In Synthesis of [ 881995-73-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 881995-73-9 ]

[ 881995-73-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 881995-73-9 ]
  • [ 486460-21-3 ]
  • [ 486460-23-5 ]
YieldReaction ConditionsOperation in experiment
84.2% With benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at -15 - 20℃; At room temperature, a 50 ml three-necked flask was charged with F (2.6 g) prepared by the oxidation reaction ,J (1.9 g), DMF (20 ml), HOBT (0.22 g), N, N-diisopropylethylamine (2.6 ml). After the reaction solution was reduced to -15-15 C, EDC (3.0 g) was added and stirring was continued at -10-5 C for 30 minutes to 120 minutes. After the reaction solution was warmed to room temperature, the reaction was continued for 1 to 5 hours. Then, 50ml of ethyl acetate and water were added, stirred well, and separated. The aqueous layer was extracted once with 30ml of ethyl acetate. The organic layers were combined, washed with 30ml of water and concentrated to obtain G4.41g as an off white solid with a molar yield of 84.2%
 

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