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Chemical Structure| 883-33-0 Chemical Structure| 883-33-0

Structure of 883-33-0

Chemical Structure| 883-33-0

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Product Details of [ 883-33-0 ]

CAS No. :883-33-0
Formula : C13H7IO
M.W : 306.10
SMILES Code : O=C1C2=C(C3=C1C=CC=C3)C(I)=CC=C2

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Application In Synthesis of [ 883-33-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 883-33-0 ]

[ 883-33-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6223-83-2 ]
  • [ 883-33-0 ]
YieldReaction ConditionsOperation in experiment
With [bis(acetoxy)iodo]benzene; iodine; In tetrachloromethane; at 78℃; for 20.0h;Photochemical reactor; Irradiation; Example 2 Synthesis of [4-(benzofuran-2-yl)-9H-fluoren-9(R,S)-yl)]-amide of 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid Stage 1: Introduce successively 5 g of <strong>[6223-83-2]9-fluorenone-4-carboxylic acid</strong>, 22 g of iodobenzene diacetate, 17 g of doubly sublimed iodine and 450 mL of carbon tetrachloride in a photochemical reactor containing a 125 W lamp. After heating for 20 hours at 78 C. under radiation, add 300 mL of a 10% aqueous solution of sodium thiosulphate and stir for 15 minutes. Remove the precipitate (unreacted starting product) and purify the organic phase of the filtrate by flash chromatography on silica gel (20-40 mum), eluding with a mixture of cyclohexane and ethyl acetate (90-10 by volume). We thus obtain 1.59 g of 4-iodo-fluoren-9-one in the form of a yellow solid with the following characteristics: Mass spectrum (E/I): m/z=306 (M+) 1H NMR spectrum (400 MHz, delta in ppm, DMSO-d6): 7.14 (t, J=8.0 Hz, 1H); 7.48 (d broad, J=7.5 Hz, 1H); 7.66 (dd, J=1.0 and 7.5 Hz, 1H); 7.69 (d broad, J=8.0 Hz, 1H); 7.74 (dt, J=1.0 and 7.5 Hz, 1H); 8.05 (dd, J=1.0 and 7.5 Hz, 1H); 8.59 (d broad, J=8.0 Hz, 1H).
 

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