Home Cart 0 Sign in  

[ CAS No. 886365-00-0 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 886365-00-0
Chemical Structure| 886365-00-0
Structure of 886365-00-0 * Storage: {[proInfo.prStorage]}

Quality Control of [ 886365-00-0 ]

Related Doc. of [ 886365-00-0 ]

SDS
Alternatived Products of [ 886365-00-0 ]
Alternatived Products of [ 886365-00-0 ]

Product Details of [ 886365-00-0 ]

CAS No. :886365-00-0 MDL No. :MFCD07375099
Formula : C6H5Cl2N Boiling Point : 219.3°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :162.02 g/mol Pubchem ID :22087228
Synonyms :

Safety of [ 886365-00-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 886365-00-0 ]

  • Downstream synthetic route of [ 886365-00-0 ]

[ 886365-00-0 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 14068-53-2 ]
  • [ 886365-00-0 ]
  • [ 1420066-36-9 ]
YieldReaction ConditionsOperation in experiment
22% With N-ethyl-N,N-diisopropylamine; In toluene; at 120.0℃; for 16.0h;Sealed tube; General procedure: A mixture of 6 (1.55 mmol), 2 (0.77 mmol), and i-Pr2NEt(1.55 mmol) in toluene (unless otherwise stated) (0.77 ml) was stirred at 120 C in a sealed tube for 16 h. The mixture was allowed to cool to room temperature. Purification method A: the mixture was concentrated and the residue was purified by reverse phase automatedpreparative HPLC. Purification method B: the mixture was concentrated and the residue was purified by flash column chromatography (SiO2). Purification method C: the mixture was diluted(DCM), washed (satd Na2CO3), dried (filtered through a Biotage phase separator), and concentrated. The residue was purified by reverse phase automated preparative HPLC.
  • 2
  • [ 886365-00-0 ]
  • 2-methyl-8-(4-methyl-5-(p-tolyl)pyridin-2-yl)benzofuro[2,3-b]pyridine [ No CAS ]
  • 3
  • [ 886365-00-0 ]
  • 2-(Methyl-d3)-8-(4-(methyl-d3)-5-(4-(methyl-d3)phenyl)pyridin-2-yl)benzofuro[2,3-b]pyridine [ No CAS ]
  • 4
  • [ 886365-00-0 ]
  • C49H24(2)H15IrN4O [ No CAS ]
  • 5
  • [ 886365-00-0 ]
  • [ 1609374-04-0 ]
  • 8-(5-chloro-4-methylpyridin-2-yl)-2-methylbenzofuro[2,3-b]pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
83% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,2-dimethoxyethane; water; at 100.0℃; for 14.0h;Inert atmosphere; 2,5-Dichloro-4-methylpyridine (7 g, 43.2 mmol), 2-methyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuro[2,3-b]pyridine (13.36 g, 43.2 mmol), and potassium carbonate (11.94 g, 86 mmol) were suspended in a mixture of DME (180 ml) and water (10 ml) under nitrogen at room temperature. Tetrakis(triphenylphosphine)palladium(0) (Pd(PPh3)4) (0.499 g, 0.432 mmol) was added as one portion, the reaction mixture was degassed and heated at 100 C. for 14 hours under nitrogen. The reaction mixture was then cooled down to room temperature and the organic phase was separated and filtered. Ethanol (100 ml) was added as one portion and the resulting mixture was stirred, then the white precipitate was filtered off. The remaining solution was evaporated and the residue was subjected to column chromatography on silica gel column, eluted with heptanes/DCM 1/1 (v/v), then heptanes/EtOAc 4/1 (v/v) to yield a white solid, which was combined with the white precipitate. The combined solids were recrystallized from DCM/heptanes, yielding 8-(5-chloro-4-methylpyridin-2-yl)-2-methylbenzofuro[2,3-b]pyridine (11 g, 83% yield).
  • 6
  • [ 886365-00-0 ]
  • [ 147081-49-0 ]
  • (R)-tert-butyl 3-((5-chloro-4-methylpyridin-2-yl)amino)pyrrolidine-1-carboxylate [ No CAS ]
  • 7
  • [ 886365-00-0 ]
  • potassium vinyltrifluoroborate [ No CAS ]
  • 5-chloro-4-methyl-2-vinylpyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; triethylamine; In ethanol; at 120.0℃; for 0.333333h;Inert atmosphere; Microwave irradiation; General procedure: 5-bromo-2-fluorobenzonitrile (500 mg, 2.5 mmol), potassium trifluoro(vinyl)borate (402 mg, 3 mmol), l,r-bis(diphenylphosphino)fenOcene-palladium(II)di chloride dichloromethane complex (102 mg, 125 pmol) and triethylamine (253 mg, 2.5 mmol) were dispersed in 12 ml ethanol, degassed with argon and reacted in the microwave (120 C, 20 min). The mixture was then concentraed in vacuo, diluted with EtOAc, washed with water, dried over Na2SC>4, filtered and concentrated in vacuo before it was purified by silica column chromatography (50 g, EtOAc in Hept 0% to 50%). The product was obtained as a white solid (312 mg). Product confirmed by 1H-NMR
Historical Records

Related Functional Groups of
[ 886365-00-0 ]

Chlorides

Chemical Structure| 191419-07-5

[ 191419-07-5 ]

2,3-Dichloro-4-methylpyridine

Similarity: 0.95

Chemical Structure| 53939-29-0

[ 53939-29-0 ]

2,3,5-Trichloro-4-methylpyridine

Similarity: 0.93

Chemical Structure| 102645-35-2

[ 102645-35-2 ]

2,5-Dichloroisonicotinonitrile

Similarity: 0.87

Chemical Structure| 329794-26-5

[ 329794-26-5 ]

2,3-Dichloro-4-(chloromethyl)pyridine

Similarity: 0.87

Chemical Structure| 102645-33-0

[ 102645-33-0 ]

2,5-Dichloroisonicotinaldehyde

Similarity: 0.87

Related Parent Nucleus of
[ 886365-00-0 ]

Pyridines

Chemical Structure| 191419-07-5

[ 191419-07-5 ]

2,3-Dichloro-4-methylpyridine

Similarity: 0.95

Chemical Structure| 53939-29-0

[ 53939-29-0 ]

2,3,5-Trichloro-4-methylpyridine

Similarity: 0.93

Chemical Structure| 102645-35-2

[ 102645-35-2 ]

2,5-Dichloroisonicotinonitrile

Similarity: 0.87

Chemical Structure| 329794-26-5

[ 329794-26-5 ]

2,3-Dichloro-4-(chloromethyl)pyridine

Similarity: 0.87

Chemical Structure| 102645-33-0

[ 102645-33-0 ]

2,5-Dichloroisonicotinaldehyde

Similarity: 0.87