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[ CAS No. 886365-22-6 ]

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Chemical Structure| 886365-22-6
Chemical Structure| 886365-22-6
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Product Details of [ 886365-22-6 ]

CAS No. :886365-22-6 MDL No. :MFCD07375111
Formula : C7H6BrNO3 Boiling Point : 400.8±45.0°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :232.03 g/mol Pubchem ID :57355294
Synonyms :

Safety of [ 886365-22-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 886365-22-6 ]

  • Upstream synthesis route of [ 886365-22-6 ]
  • Downstream synthetic route of [ 886365-22-6 ]

[ 886365-22-6 ] Synthesis Path-Upstream   1~6

  • 1
  • [ 886365-22-6 ]
  • [ 913836-17-6 ]
Reference: [1] Patent: US2014/94456, 2014, A1,
[2] Patent: WO2015/153683, 2015, A1,
  • 2
  • [ 886365-25-9 ]
  • [ 886365-22-6 ]
YieldReaction ConditionsOperation in experiment
62% With lithium hydroxide monohydrate; water In tetrahydrofuran at 25℃; for 2 h; A mixture of lithium hydroxide monohydrate (13.98g, 333.25mmol) and methyl 5- bromo-2-methoxy-pyridine-4-carboxylate (16 .40g, 66 .65mmol) in tetrahydrofuran (30mL) /water (6mL) was stirred at 25 °C for 2 h. The mixture was concentrated under reduced pressure. The aqueous residue was diluted with water (l0mL) and adjusted to pH=4 by addition of hydrochloric acid (2 M, 80 mL). The mixture was extracted with ethyl acetate (3 x 1 0mL). The combined organic layers were dried over sodium sulfate and concentrated under reduced pressure to afford crude 5-bromo-2-methoxy-pyridine-4-carboxylic acid (9.62g,62percent) as brown oil. LCMS RT = 0.448 mi m/z = 231.9 [M + H]. LCMS (5 to 95percent acetonitrile in water + 0.03percent trifluoacetic acid over 1.5 mins) retention time 0.448 mi ESI+ found [M+H] = 231.9.
Reference: [1] Patent: WO2018/73193, 2018, A1, . Location in patent: Page/Page column 74; 75
  • 3
  • [ 936011-17-5 ]
  • [ 886365-22-6 ]
Reference: [1] Patent: US2014/94456, 2014, A1, . Location in patent: Paragraph 0925-026
[2] Patent: WO2015/153683, 2015, A1, . Location in patent: Paragraph 0717
  • 4
  • [ 13472-85-0 ]
  • [ 886365-22-6 ]
Reference: [1] Patent: US2014/94456, 2014, A1,
[2] Patent: WO2015/153683, 2015, A1,
  • 5
  • [ 67-56-1 ]
  • [ 886365-22-6 ]
  • [ 886365-25-9 ]
Reference: [1] Patent: US2014/94456, 2014, A1, . Location in patent: Paragraph 0925-026
[2] Patent: WO2015/153683, 2015, A1, . Location in patent: Paragraph 0717
  • 6
  • [ 886365-22-6 ]
  • [ 913836-16-5 ]
Reference: [1] Patent: US2014/94456, 2014, A1,
[2] Patent: WO2015/153683, 2015, A1,
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