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[ CAS No. 886371-78-4 ]

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Chemical Structure| 886371-78-4
Chemical Structure| 886371-78-4
Structure of 886371-78-4 * Storage: {[proInfo.prStorage]}

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Product Details of [ 886371-78-4 ]

CAS No. :886371-78-4 MDL No. :MFCD07374895
Formula : C6H4FNO2 Boiling Point : 292.3°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :141.10 g/mol Pubchem ID :18327805
Synonyms :

Safety of [ 886371-78-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 886371-78-4 ]

  • Downstream synthetic route of [ 886371-78-4 ]

[ 886371-78-4 ] Synthesis Path-Downstream   1~15

  • 1
  • [ 886371-78-4 ]
  • [ 89499-43-4 ]
  • [ 1354412-82-0 ]
YieldReaction ConditionsOperation in experiment
56% Preparation of a Compound of Formula (5) in which X2 is CH, X3 is S, X4 is CH, X5 is N, and Y is 4-(4-cyclopropyl-1H-imidazol-1-yl) Step 1-Preparation of a Compound of Formula (19) in which R is Hydrogen, Y is Fluoro, X2 is CH, X3 is S, X4 is CH, X5 is N, and OAlk is Methoxy A solution of 4-fluoropicolinic acid (1.0 g, 6.4 mmol), HATU (2.9 g, 7.6 mmol), and N-methylmorpholine (0.84 mL, 7.6 mmol) in N,N-dimethylformamide (12 mL) was stirred at 0 C. for 30 minutes. Methyl 4-aminothiophene-2-carboxylate (990 mg, 7.0 mmol) was added, the reaction was stirred for 30 minutes at 0 C., then warmed to room temperature, and stirred for an additional 2 hours. The solvent was removed under reduced pressure, the residue was suspended in acetonitrile/H2O (1:1) and the solids were isolated by filtration, washed with water, acetonitrile, then dried to afford methyl 4-(4-fluoropicolinamido)thiophene-2-carboxylate as a white powder (1.0 g, 56% yield). M+1=281.1.
  • 2
  • [ 886371-78-4 ]
  • [ 1354413-24-3 ]
  • 3
  • [ 886371-78-4 ]
  • [ 1354412-83-1 ]
  • 4
  • [ 886371-78-4 ]
  • [ 1354412-84-2 ]
  • 5
  • [ 886371-78-4 ]
  • [ 89830-98-8 ]
  • 4-(4-cyclopropyl-1H-imidazol-1-yl)picolinic acid hydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
69% A mixture of 4-fluoropicolinic acid (400 mg, 2.84 mmol) and <strong>[89830-98-8]4-cyclopropyl-1H-imidazole</strong> (322 mg, 2.98 mmol) were dissolved in N,N-dimethylformamide, and N-methylmorpholine (0.36 ml, 3.28 mmol) was added. The reaction was warmed to 35° C., and stirred for 20 hours. The solvent was then removed under reduced pressure to afford a viscous oily residue. This residue was dissolved in 1N hydrochloric acid (5 mL), and the aqueous layer was extracted with ethyl acetate (2*5 mL). The aqueous layer was concentrated under reduced pressure to afford a yellow solid. To this residue was added 5 mL of acetonitrile/methanol (20:1) and the mixture was sonicated to afford a fine suspension of solids.The solids were collected by filtration, washed several times with acetonitrile, and dried on the filter funnel.The yellow solids were collected to afford 520 mg (69percent yield) of 4-(4-cyclopropyl-1H-imidazol-1-yl)picolinic acid as the hydrochloride salt. M+1=230.1
  • 6
  • [ 886371-78-4 ]
  • 5-(pyrimidin-5-yloxy)pyridin-3-amine hydrochloride [ No CAS ]
  • [ 76-05-1 ]
  • 4-fluoro-N-(5-(pyrimidin-5-yloxy)pyridin-3-yl)picolinamide trifluoroacetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
30% d. 4-FLUORO- V-(5-(PYRIMIDIN-5-YLOXY)PYRIDIN-3-YL)PICOLINAMIDE (8).[00319] Compound 7 (100 mg, 0.53 mmol, 1.2 eq), <strong>[886371-78-4]4-fluoropicolinic acid</strong> (52 mg, 0.37 mmol, 1.0 eq), O-(7-Azabenzotriazol-l-yl)-N,NN'N-tetramethyluroniumhexafluorophosphate (300 mg, 0.789 mmol, 2.10 eq), and N^V-Diisopropylethylamine (200 mg, 1.55 mmol, 4.10 eq) were dissolved in CH2C12 (4.0 mL) and DMF (0.83 mL) and stirred at rt overnight. The reaction was quenched with water, and the layers were separated via phase separation. The organic layer was dried on air concentrator and purified by reverse- phase preparatory HPLC to afford 34 mg (30%) of the mono-TFA salt as a yellow oil: 1H NMR (400 MHz, DMSO-<¾ delta 9.09 (s, 1H), 9.03 (d, J= 1.9 Hz, 1H), 8.81-8.77 (m, 3H), 8.30 (d, J= 2.6 Hz, 1H), 8.12 (t, J= 2.3 Hz, 1H), 7.96 (dd, J= 9.5, 2.5 Hz, 1H), 7.67-7.63 (m, 1H); ES-MS [M+1]+:312.1.
  • 7
  • [ 886371-78-4 ]
  • [ 1279462-04-2 ]
  • 8
  • [ 886371-78-4 ]
  • [ 100-36-7 ]
  • [ 1420844-60-5 ]
  • 9
  • [ 886371-78-4 ]
  • [ 1440967-35-0 ]
  • C27H27FN4O5S [ No CAS ]
  • 10
  • [ 886371-78-4 ]
  • C6H3ClFNO [ No CAS ]
YieldReaction ConditionsOperation in experiment
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20℃;Cooling with ice; 4-oxalyl chloride (779muL) and DMF (1 drop) under ice-cooling to a methylene chloride solution (26mL) of fluoro-pyridine-2-carboxylic acid (650mg) was added.After stirring overnight at room temperature, the reaction mixture was concentrated.The residue was dissolved in methylene chloride was added dropwise under ice-cooling in methylene chloride solution (12 mL) of the compound obtained in Reference Example 137 (500mg) and triethylamine (641muL), and the reaction mixture was stirred at room temperature for 3.5 hours.Water and saturated sodium hydrogen carbonate aqueous solution was added to the reaction mixture, the mixture was extracted four times with chloroform.The organic layer was dried over anhydrous magnesium sulfate, filtered, concentrated and the residue was purified by silica gel column chromatography; was purified by (solvent: hexane / ethyl acetate = 80 / 20-50 / 50).In dichloroethane obtained product solution (20 mL), triethylamine (8.99mL) and chlorotrimethylsilane (2.72 mL) was added, and the reaction mixture was stirred for 4 hours at room temperature.Water was added to the reaction mixture, the mixture was extracted twice with chloroform.The organic layer was dried over anhydrous magnesium sulfate, filtered, and concentrated.The residue was purified by silica gel column chromatography; was purified by (solvent hexane / ethyl acetate = 70 / 30-0 / 100), highly polar compounds by TLC on silica gel (Reference Example 262; 393mg) and low-polar compounds (Reference Example 263 ; 142mg) was obtained.
With thionyl chloride; at 90℃; for 1h; In an 8-mL vial, <strong>[886371-78-4]4-fluoropicolinic acid</strong> (352 mg, 2.5 mmol) was dissolved in 4 mL thionyl chloride, and then the mixture was stirred at 90 C for 1 h. After finished, the mixture was concentrated in vacuum, and then dissolved in 5 mL anhydrous DCM. And then the solution was added dropwise to a solution of 3-aminopiperidine-2,6-dione hydrochloride (412 mg, 2.5 mmol) and Et3N (1.7 mL, 12.5 mmol) in DCM (10 mL) at 0 C, the mixture was stirred at room temperature for 1 h, and then concentrated to afford the crude int-1 (443 mg, 71%).
  • 11
  • [ 886371-78-4 ]
  • C13H13FN4O2S2 [ No CAS ]
  • 12
  • [ 886371-78-4 ]
  • 6-ethyl-5-(4-fluoro-2-yl)-2-methylsulfanyl[1,3]thiazolo[5,4-d]pyrimidin-7(6H)-one [ No CAS ]
  • 5-(4-chloro-2-yl)-6-ethyl-2-methylsulfanyl[1,3]thiazolo[5,4-d]pyrimidin-7(6H)-one [ No CAS ]
  • 13
  • [ 886371-78-4 ]
  • C39H44ClN9O6S [ No CAS ]
  • 14
  • [ 886371-78-4 ]
  • C11H10FN3O3 [ No CAS ]
  • 15
  • [ 886371-78-4 ]
  • C24H37N5O5 [ No CAS ]
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