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Chemical Structure| 892871-54-4 Chemical Structure| 892871-54-4

Structure of 892871-54-4

Chemical Structure| 892871-54-4

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Product Details of [ 892871-54-4 ]

CAS No. :892871-54-4
Formula : C13H17NO3
M.W : 235.28
SMILES Code : O=C1N(CCOCC2=CC=CC=C2)CCOC1

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Application In Synthesis of [ 892871-54-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 892871-54-4 ]

[ 892871-54-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 109-11-5 ]
  • [ 1462-37-9 ]
  • [ 892871-54-4 ]
YieldReaction ConditionsOperation in experiment
49% To a solution of <strong>[109-11-5]morpholin-3-one</strong> (cas: 109-11-5, 2 g, 19.8 mmol) in anhydrous DMF (25 mL) was added NaH (60% dispersion in mineral oil, 1.98 g, 2.5 equiv.) at 0 C under N2. The reaction mixture was stirred for 30 minutes and then ((2- bromoethoxy)methyl)benzene (cas: 1462-37-9, 1.98 g, 2.5 equiv.) was added to the reaction mixture, which was then allowed to warm to ambient temperature. After 12 hours, analysis by LC-MS indicated completion of the reaction. The reaction mixture was quenched with H20 (20 mL) and extracted with EtOAc (20 mL x 3). The combined organic extracts were concentrated under reduced pressure to give the crude product, which was purified by silica gel chromatography (Petroleum ether: EtOAc = 1 :4) to provide morpholinone 1-339 as a pale oil (2.3 g, 49% yield). MS (ESI, pos. ion) m/z: 236(M+l).
 

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