Alternatived Products of [ 89324-44-7 ]
Product Details of [ 89324-44-7 ]
CAS No. : | 89324-44-7 |
MDL No. : | MFCD01859867 |
Formula : |
C6H4O3S
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
156.16
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 89324-44-7 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 89324-44-7 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 89324-44-7 ]
- Downstream synthetic route of [ 89324-44-7 ]
- 1
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[ 88-13-1 ]
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[ 19991-69-6 ]
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[ 89324-44-7 ]
Yield | Reaction Conditions | Operation in experiment |
|
With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; |
Reference Example 132 2-Difluoromethyl-3-thiphenecarboxylic Acid 3-Thiophenecarboxylic acid (3.48 g) was dissolved in tetrahydrofuran (50 ml), and N,N,N',N'-tetramethylethylenediamine (10 ml) was added. The mixture was cooled to -78 C., and n-butyllithium (1.6M in hexane, 41.3 ml) was slowly added dropwise. The mixture was stirred at the same temperature for 1 hour, and N,N-dimethylformamide (4.6 ml) was added dropwise. The mixture was warmed to room temperature and stirred for 15 hours. The reaction mixture was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give a mixture of 2-formyl-3-thiophenecarboxylic acid and 5-formyl-3-thiophenecarboxylic acid (2.11 g). |
- 2
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[ 100523-84-0 ]
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[ 109-72-8 ]
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[ 89324-44-7 ]
Yield | Reaction Conditions | Operation in experiment |
|
In tetrahydrofuran; hexane; N,N-dimethyl-formamide; |
Reference Example 142 5-Difluoromethyl-3-thiophenecarboxylic Acid 5-Bromo-3-thiophenecarboxylic acid (4.14 g) was dissolved in tetrahydrofuran (50 ml), and the mixture was cooled to -78 C. n-Butyllithium (1.6M in hexane, 27.5 ml) was slowly added dropwise. The resulting mixture was stirred at the same temperature for 1 hour, and N,N-dimethylformamide (3.1 ml) was added. The mixture was warmed slowly to room temperature and concentrated under reduced pressure. The concentrate was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give a crude product of 5-formyl-3-thiophenecarboxylic acid (3.12 g). |