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Chemical Structure| 89639-36-1 Chemical Structure| 89639-36-1

Structure of 89639-36-1

Chemical Structure| 89639-36-1

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Product Details of [ 89639-36-1 ]

CAS No. :89639-36-1
Formula : C6H7ClN2
M.W : 142.59
SMILES Code : NC1=CC(Cl)=CN=C1C
MDL No. :MFCD12196974
InChI Key :ZZVRTFCAHUHTDJ-UHFFFAOYSA-N
Pubchem ID :18727791

Safety of [ 89639-36-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 89639-36-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 89639-36-1 ]

[ 89639-36-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 4565-31-5 ]
  • [ 89639-36-1 ]
  • C12H9ClN2O2S [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol; at 50℃; for 2h;Inert atmosphere; To a solution of <strong>[4565-31-5]5-formyl-thiophene-2-carboxylic acid</strong> (19.7g, 126mmol) in methanol (200mL) under nitrogen atmosphere was added 5-chloro-2-methylpyrid ine-3-amine ( 1 7.99g, 126mmol). The mixture was heated to 50°C for 2h; the reaction mixture was concentrated under reduced pressure to obtain a solid. The solid material was dissolved in methanol (200mL) and cooled to 0°C then sodium cyanoborohydride (9.5 1 g, 1 51 mmol) was added over 10 minutes and the resulting mixture was stirred at room temperature for 14 h. The reaction mixture was quenched by adding IN HC1 ( l OOmL) to bring pH=4, concentrated under vacuum. The residue was diluted with water ( l OOm L). The resulting tan suspension was filtered and dried to get crude solid (28 g, crude). The solid was triturated with ethyl acetate (50mL) to get 5- [(5-chloro-2-methyl-3- pyridinyl)amino]methyl} -2-thiophenecarboxylic acid (27g) as a pale yellow solid.
 

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[ 89639-36-1 ]

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