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Chemical Structure| 89979-13-5 Chemical Structure| 89979-13-5

Structure of 89979-13-5

Chemical Structure| 89979-13-5

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Product Details of [ 89979-13-5 ]

CAS No. :89979-13-5
Formula : C8H8ClNO4S
M.W : 249.67
SMILES Code : O=C(OCC1=CC=CC=C1)NS(=O)(Cl)=O
English Name :Benzyl chlorosulfonylcarbamate
MDL No. :MFCD19200062

Safety of [ 89979-13-5 ]

Application In Synthesis of [ 89979-13-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 89979-13-5 ]

[ 89979-13-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ CAS Unavailable ]
  • [ 89979-13-5 ]
  • [ 92577-65-6 ]
YieldReaction ConditionsOperation in experiment
In dichloromethane
  • 2
  • [ 1189-71-5 ]
  • [ 89979-13-5 ]
  • [ 14365-44-7 ]
  • [ 213554-34-8 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; benzyl alcohol In dichloromethane 2 Preparation of 5'-deoxy-adenosine 5'-N-(N-L-phenylalanyl)sulfamide (CB 16913) Example 2 Preparation of 5'-deoxy-adenosine 5'-N-(N-L-phenylalanyl)sulfamide (CB 16913) To a stirred 0° C. solution of chlorosulfonylisocyanate (5.33 mL) in dichlomethane (100 ml), was added dropwise benzyl alcohol (6.34 ml), and the mixture was stirred at 0° C. for 1 h. The solvent was evaporated and the resulting white colored residue was redissolved in dichloromethane (100 ml), and added via cannula to an ice-cold solution of 5'-amino-5'-deoxy-adenosine (17.07 g) and triethylamine (40 ml) in dichloromethane (500 ml). The resulting reaction mixture was allowed to warm to room temperature overnight. After 14 h, an additional amount of N-benzyloxycarbonylsulfamoyl chloride (2.5 g) was added. After an additional 24 h the mixture was washed with water (200 ml) and dried over anhydrous sodium sulfate. Evaporation of the solvent gave 5'-deoxy-2',3'-O-(1-methylethylidene)-adenosine 5'-N-[(phenylmethoxy)carbonyl]-sulfamide as an off white colored solid (39.5 g).
 

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