Home Cart Sign in  
Chemical Structure| 90345-22-5 Chemical Structure| 90345-22-5

Structure of 90345-22-5

Chemical Structure| 90345-22-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 90345-22-5 ]

CAS No. :90345-22-5
Formula : C7H10N2O
M.W : 138.17
SMILES Code : NC1=NC(C)=CC(OC)=C1
MDL No. :MFCD16606202

Safety of [ 90345-22-5 ]

Application In Synthesis of [ 90345-22-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 90345-22-5 ]

[ 90345-22-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 67-56-1 ]
  • [ 36340-61-1 ]
  • [ 90345-22-5 ]
YieldReaction ConditionsOperation in experiment
With sodium t-butanolate; at 130℃; for 12.0h;Inert atmosphere; Microwave irradiation; To <strong>[36340-61-1]4-chloro-6-methylpyridin-2-amine</strong> (1.0 g, 7.0 mmol) was added sodium methoxide (25% solution in methanol, 9.2 ml, 35 mmol) under a nitrogen atmosphere. The reaction mixture was heated in a microwave at 130C for 12 hours. The reaction mixture was quenched with hydrochloric acid (1.0 M in water, 42 ml, 42 mmol), and the reaction mixture was partially concentrated under reduced pressure to remove methanol. The residue was diluted with ethyl acetate, and the pH was adjusted to ~7.5 with saturated aqueous sodium bicarbonate solution. The organics were separated, dried over sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica gel chromatography(dichloromethane/methanol with ammonium hydroxide, linear gradient) to afford 4-mefhoxy-6- methylpyridin-2-amine. MS ESI calc'd. for C7HnN20 [M + H]+ 139, found 139. 1H NMR (500 MHz, DMSO-d6) delta 5.96 (d, J= 1.5 Hz, 1H), 5.75 (d, J= 2.0 Hz, 1H), 5.70 (br s, 2H), 3.66 (s, 3H), 2.13 (s, 3H).
  • 2
  • [ 124-41-4 ]
  • [ 36340-61-1 ]
  • [ 90345-22-5 ]
YieldReaction ConditionsOperation in experiment
110 mg In dimethyl sulfoxide; at 140℃; for 18.0h; A suspension of <strong>[36340-61-1]4-chloro-6-methylpyridin-2-amine</strong> (284 mg, 2 mmol) in DMSO (10 mL) was added sodium methanolate (540 mg, 10 mmol), and the resulting mixture was then stirred for 18 hours at 140 C. The reaction was filtered and the filtrate was purified via prep-HPLC to afford 4-methoxy-6-methylpyridin-2-amine (110 mg) as brown solid. MS ESI calcd. For C7H10N2O [M + H]+ 139, found 139.
 

Historical Records