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Chemical Structure| 903556-00-3 Chemical Structure| 903556-00-3

Structure of 903556-00-3

Chemical Structure| 903556-00-3

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Product Details of [ 903556-00-3 ]

CAS No. :903556-00-3
Formula : C10H11ClN2
M.W : 194.66
SMILES Code : N#CC1=CC2=C([C@H](N)CC2)C=C1.[H]Cl
MDL No. :MFCD22392465

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Application In Synthesis of [ 903556-00-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 903556-00-3 ]

[ 903556-00-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 903556-00-3 ]
  • [ 745784-04-7 ]
  • (R)-N-(5-cyano-2,3-dihydro-1H-inden-1-yl)-3,5-difluoropicolinamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
32% To a screw top vial equipped with a stir bar was added <strong>[745784-04-7]3,5-difluoropicolinic acid</strong> (159 mg, 1 mmol), 1H-benzo[dj[1,2,3jtriazol-1-ol (176 mg, 1.300 mmol), EDC hydrochloride (249 mg, 1.300 mmol), DMF (5 mL) and Et3N (418 pE, 3.00 mmol). The reaction mixture was stirred for 5 minutes at room temperature. Next (R)-1-amino-2,3- dihydro-1H-indene-5-carbonitrile hydrochloride (253 mg, 1.300 mmol) was added. The reaction mixture was stirred at room temperature overnight and then filtered. The filtrate was purified by preparative HPLC, eluting with a gradient of 25-50% acetonitrile in water (containing TFA) to give the title compound as an off-white solid (97 mg, 32%). ESI-MS mlz [M+Hj 300.0.
 

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