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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 90779-69-4 Chemical Structure| 90779-69-4

Structure of Atosiban
CAS No.: 90779-69-4

Chemical Structure| 90779-69-4

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Atosiban is competitive antagonist of vasopressin and oxytocin receptors. It is a nonapeptide and the analogue of desamino-oxytocin.

Synonyms: RW22164; RWJ22164; Tractocile

4.5 *For Research Use Only !

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Product Details of Atosiban

CAS No. :90779-69-4
Formula : C43H67N11O12S2
M.W : 994.19
SMILES Code : O=C([C@H]1N(C([C@@H](NC([C@H](CC(N)=O)NC([C@H]([C@H](O)C)NC([C@H]([C@@H](C)CC)NC([C@@H](CC2=CC=C(OCC)C=C2)N3)=O)=O)=O)=O)CSSCCC3=O)=O)CCC1)N[C@@H](CCCN)C(NCC(N)=O)=O
Synonyms :
RW22164; RWJ22164; Tractocile
MDL No. :MFCD00672436

Safety of Atosiban

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H360
Precautionary Statements:P201-P202-P280-P308+P313-P405-P501
Class:6.1
UN#:2811
Packing Group:

Related Pathways of Atosiban

GPCR

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Rat small mesenteric artery 0.3 – 3 μM 60 min Atosiban competitively antagonized OT-induced contractions of the rat SMA but caused concentration-dependent steepening of the AVP E/[A] curve (Hill slope increase), indicating receptor heterogeneity. Br J Pharmacol. 1998 Oct;125(4):865-73
Rat aortic rings 0.3 – 10 μM 60 min Atosiban competitively antagonized AVP- and OT-induced contractions of the rat aorta, with Schild slope parameters not significantly different from unity (b=0.82 ± 0.10 and 0.81 ± 0.14) and pKB values of 6.19 ± 0.06 and 6.30 ± 0.04 against AVP and OT, respectively. Br J Pharmacol. 1998 Oct;125(4):865-73
human myometrial strips 1 µM Atosiban antagonized oxytocin (OT)-induced dose-dependent (10-3000 nM) phasic contractions Br J Pharmacol. 2001 Sep;134(1):206-14

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
California mice Unstressed female mice Bilateral NAc core injection 1 ng Single injection, social interaction test conducted 30 minutes later Atosiban infusion in the NAc reduced social approach but did not induce social vigilance in unstressed females. Neuropsychopharmacology. 2020 Aug;45(9):1423-1430
ICR mice Tamoxifen-induced adenomyosis mouse model Intraperitoneal injection 1 mg/kg Once daily for 3 weeks To evaluate the effects of Atosiban on tamoxifen-induced adenomyosis in mice. Results showed that Atosiban significantly prolonged the hotplate response latency, indicating its analgesic effect, but did not significantly reduce the depth of myometrial infiltration. Drug Des Devel Ther. 2025 Apr 2;19:2533-2549
Male Sprague-Dawley rats Single prolonged stress (SPS) model Intraperitoneal injection 5 mg/kg Single administration, followed by behavioral test observations Atosiban blocked the ameliorative effect of oxytocin (OXT) on SPS-induced social behavior deficits, indicating the importance of the OXT signaling pathway in PTSD-related social behavior impairments. J Biomed Sci. 2019 Mar 21;26(1):26

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00599898 Labor, Premature Phase 4 Completed - Israel ... More >> HaEmek Medical Center Afula, Israel, 18100 Less <<
NCT01796522 Preterm Delivery. Phase 3 Withdrawn(have been published ... More >>new studies that it showed the ineffectiveness of the treatments proposed in this study.) Less << May 2013 Spain ... More >> Hospital Universitari y Politécnic La Fe Valencia, Spain, 46026 Less <<
NCT02292784 Obstetric Labour, Premature Phase 2 Phase 3 Recruiting July 29, 2022 -
NCT00587327 In Vitro Fertilisation (IVF) T... More >>reatment Less << Phase 2 Completed - Belgium ... More >> UZ Brussel, Center for Reproductive Medicine Brussels, Belgium Czechia Institute for Reproductive Medicine and Endocrinology Pilsen, Czechia, 30177 ISCARE IVF a.s. Prague, Czechia Spain Institut Universitari Dexeus Barcelona, Spain, 08028 IVI Madrid Madrid, Spain, 28035 Less <<
NCT02725736 Labor Preterm Multiple Phase 3 Unknown March 2018 -
NCT01673399 Implantation Failure Phase 4 Recruiting - Belgium ... More >> AZ Jan Palfijn Recruiting Gent, Oost-vlaanderen, Belgium, 9000 Contact: Wim Decleer, gynecologist    0032 9 2243024    wim.decleer@janpalfijngent.be    Contact    0032 9 2248851    ivf.studie@janpalfijngent.be    Principal Investigator: Wim Decleer, gynecologist Less <<
NCT03369262 Preterm Labor Phase 2 Recruiting September 2021 Finland ... More >> Helsinki Universisty Hospital Recruiting Helsinki, Finland Contact: Investigator, MD          Spain Hospital La Paz Not yet recruiting Madrid, Spain Contact: Investigator, MD Less <<
NCT01429545 Preterm Labour Phase 2 Completed - United Arab Emirates ... More >> Department of obstetrics and Gynecology, Tawam Hospital Al Ain, Abudhabi, United Arab Emirates, 15258 Tawam Hospital Al Ain, Abudhabi, United Arab Emirates, 15258 Less <<
NCT00679705 Healthy Phase 1 Completed - Belgium ... More >> University Hospital Ghent Ghent, Belgium, 9000 Less <<
NCT01314859 Threatened Preterm Labor Phase 3 Withdrawn July 2013 -
NCT02292771 Obstetric Labour, Premature Phase 3 Terminated(The study was stopp... More >>ed due to the feasibility of recruiting the study in a timely manner) Less << - -
NCT02292771 - Terminated(The study was stopp... More >>ed due to the feasibility of recruiting the study in a timely manner) Less << - -
NCT01493440 Repeated Implantation Failure Not Applicable Completed - Vietnam ... More >> IVFAS, An Sinh Hospital Ho Chi Minh City, Ho Chi Minh, Vietnam, 8 Less <<
NCT02893722 Repeated Implantation Failure Phase 1 Unknown December 2018 -
NCT03570294 Premature Birth COMPLETED 2018-12-30 Department of Obstetrics, Peri... More >>natology and Gynecology, Polish Mother's Memorial Hospital-Research Institute, ?ód?, 93-338, Poland Less <<
NCT01501214 Subfertility Phase 4 Completed - China, Guangdong ... More >> Reproductive Medical Center of Nanfang Hospital Guangzhou, Guangdong, China, 510515 Vietnam CGRH, School of Medicine Ho Chi Minh City, Vietnam Less <<
NCT03904745 Infertility, Female UNKNOWN 2021-12-30 Bezmialem University, Istanbul... More >>, 34746, Turkey|Yeditepe University, Istanbul, 34746, Turkey Less <<
NCT05693688 Preterm Birth PHASE4 COMPLETED 2024-02-29 Amsterdam University Medical C... More >>entres, location AMC, Amsterdam, Noord-Holland, 1105 AZ, Netherlands Less <<
NCT05382143 Endometriosis PHASE2 UNKNOWN 2022-07-01 Radboud University Medical Cen... More >>ter, Nijmegen, Netherlands Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.01mL

0.20mL

0.10mL

5.03mL

1.01mL

0.50mL

10.06mL

2.01mL

1.01mL

References

 

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