* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
The obtained powder of crude 7 (5.00 g, 23.6 mmol) was dissolved in a mixture of CH3CN (100 mL) and Et3N (4.94 mL, 35.4 mmol) and then di-tert-butoxycarbonate (7.73 g, 35.4 mmol) was slowly added thereto. After stirring for 14 h, the reaction mixture was concentrated in vacuo, and then the residue was dissolved in EtOAc and H2O. The organic layer was washed with aqueous NH4Cl and brine, dried and concentrated to provide 8 (5.46 g, 84percent) as white solids. 1H NMR (CDCl3) δ: 1.50 (9H, s), 2.57 (2H, t, J = 6.1 Hz), 3.45-3.74 (3H, m), 4.10-4.40 (2H, m), 7.15-7.21 (2H, m), 7.28-7.41 (3H, m).
Reference:
[1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 21, p. 6430 - 6446
The obtained powder of crude 7 (5.00 g, 23.6 mmol) was dissolved in a mixture of CH3CN (100 mL) and Et3N (4.94 mL, 35.4 mmol) and then di-tert-butoxycarbonate (7.73 g, 35.4 mmol) was slowly added thereto. After stirring for 14 h, the reaction mixture was concentrated in vacuo, and then the residue was dissolved in EtOAc and H2O. The organic layer was washed with aqueous NH4Cl and brine, dried and concentrated to provide 8 (5.46 g, 84%) as white solids. 1H NMR (CDCl3) delta: 1.50 (9H, s), 2.57 (2H, t, J = 6.1 Hz), 3.45-3.74 (3H, m), 4.10-4.40 (2H, m), 7.15-7.21 (2H, m), 7.28-7.41 (3H, m).