[ CAS No. 912368-73-1 ] {[proInfo.proName]}

Name: 912368-73-1|(S)-tert-Butyl 3-(methylamino)piperidine-1-carboxylate|95%
Brand: Ambeed
SKU: A349630
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Quality Control of [ 912368-73-1 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 912368-73-1 ]

SDS Specification

Alternatived Products of [ 912368-73-1 ]

Product Details of [ 912368-73-1 ]

CAS No. :	912368-73-1	MDL No. :	MFCD09752964
Formula :	C₁₁H₂₂N₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	XRRRUOWSHGFPTI-VIFPVBQESA-N
M.W :	214.31	Pubchem ID :	25631268
Synonyms :

Calculated chemistry of [ 912368-73-1 ]

Physicochemical Properties

Num. heavy atoms :	15
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.91
Num. rotatable bonds :	4
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	64.2
TPSA :	41.57 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.73 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.91
Log Po/w (XLOGP3) :	1.24
Log Po/w (WLOGP) :	1.22
Log Po/w (MLOGP) :	1.15
Log Po/w (SILICOS-IT) :	0.76
Consensus Log Po/w :	1.46

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.69
Solubility :	4.42 mg/ml ; 0.0206 mol/l
Class :	Very soluble
Log S (Ali) :	-1.71
Solubility :	4.17 mg/ml ; 0.0195 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.72
Solubility :	4.08 mg/ml ; 0.0191 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.78

Safety of [ 912368-73-1 ]

Signal Word:	Danger	Class:	6.1
Precautionary Statements:	P264-P270-P280-P301+P310-P305+P351+P338-P330-P337+P313-P405-P501	UN#:	2810
Hazard Statements:	H301-H319-H400	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 912368-73-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 912368-73-1 ]
Downstream synthetic route of [ 912368-73-1 ]

[ 912368-73-1 ] Synthesis Path-Upstream 1~2

1
[ 50-00-0 ]
[ 625471-18-3 ]
[ 912368-73-1 ]

Yield	Reaction Conditions	Operation in experiment
3 g	Stage #1: at 20℃; for 24 h; Molecular sieve Stage #2: at 20℃; for 16 h;	To a stirred solution of aqueous formaldehyde (1.85 ml, 25 mmol, 37percent) and molecular sieves in methanol was added (S)-tert-butyl 3-aminopiperidine- 1 -carboxylate (5.0 g, 25 mmol) and reaction was stirred at room temperature for 24 h. Sodium borohydride (1.52 g,40 mmol) was added to the above mixture at room temperature and mixture was stirred for16 h. The reaction mixture was quenched with addition of ice water (30 mL) and thenextracted with EtOAc (3 x 100 mL). Combined organic extracts were dried over anhydrousNa2504 and concentrated to obtain 3.0 g of crude (S)-tert-butyl 3-(methylamino)piperidine-1 -carboxylate as pale yellow liquid. This material was used as such in the next step.‘H NMR (400 MHz, CDC13) ö ppm 1.38 (s, 9H), 1.5-1.7 (m, 4H), 1.71-1.90 (m, 2H), 2.18-2.27 (m, 3H), 2.75-2.90 (m, 1H), 3.50-3.92 (m, 2H).

Reference： [1] Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 1061 - 1073
[2] Patent: WO2018/2437, 2018, A1, . Location in patent: Page/Page column 99

2
[ 625471-18-3 ]
[ 912368-73-1 ]

Reference： [1] Patent: WO2006/106326, 2006, A1,

[ 912368-73-1 ] Synthesis Path-Downstream 1~18

1
C₁₁H₂₀N₂O₂ [ No CAS ]
[ 912368-73-1 ]

Yield	Reaction Conditions	Operation in experiment
		tert-butyl (3S)-3-(methylamino)piperidine-l-carboxyIate; To a solution of formaldehyde (37%, aq.; 0.37 ml, 4.7 mmol) in 20 ml dry MeOH containing 3A molecular sieves is added tert-butyl (3£)-3-aminopiperidine-l-carboxylate (1.0 g, 5 mmol). The reaction is stirred under N2 at rt for ~30h, and then NaBH4 (304 mg, 8 mmol) is added as a solid. The reaction is stirred at rt overnight and then quenched with IN NaOH (-10 ml). The phases are separated and the remaining aqueous layer is extracted with ether (3x). The combined organic layers are washed with water and brine, dried, and evaporated to yield a colorless oil (1.04 g, 100%). LCMS (ES, M+H=215).

Reference： [1]Patent: WO2006/106326,2006,A1 .Location in patent: Page/Page column 69

2
[ 912368-73-1 ]
(S)-tert-butyl 3-((5-cyano-6-(4-isopropylphenylamino)pyrazin-2-yl)(methyl)amino)piperidine-1-carboxylate [ No CAS ]

Reference： [1]Patent: WO2016/196776,2016,A2

3
[ 912368-73-1 ]
(S)-tert-butyl 3-((5-carbamoyl-6-(4-isopropylphenylamino)pyrazin-2-yl)(methyl)amino)piperidine-1-carboxylate [ No CAS ]

Reference： [1]Patent: WO2016/196776,2016,A2

4
[ 912368-73-1 ]
(S)-3-(4-isopropylphenylamino)-5-(methyl(piperidin-3-yl)amino)pyrazine-2-carboxamide hydrochloride [ No CAS ]

Reference： [1]Patent: WO2016/196776,2016,A2

5
[ 912368-73-1 ]
(S)-5-((1-acryloylpiperidin-3-yl)(methyl)amino)-3-(4-isopropylphenylamino)pyrazine-2-carboxamide formate [ No CAS ]

Reference： [1]Patent: WO2016/196776,2016,A2

6
[ 912368-73-1 ]
[ 313339-92-3 ]
(S)-tert-butyl 3-((6-chloro-5-cyanopyrazin-2-yl)(methyl)amino)piperidine-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
71%	With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; for 3h;	To a solution of 3,5-dichloropyrazine-2-carbonitrile (1035 mg, 5.98 mmol) in DMF (10 mL) were added <strong>[912368-73-1](S)-tert-butyl 3-(methylamino)piperidine-1-carboxylate</strong> (1280 mg, 5.98 mmol) and DIPEA (1.25 mL, 7.2 mmol) in a dropwise manner. The mixture was stirred at room temperature for 3 hrs. The reaction mixture was diluted with 200 mL EtOAc, washed with brine x3, dried, concentrated in vacuo and subjected to silica flash column with 0 to 60% EtOAc in hexane to give (S)-tert-butyl 3-((6-chloro-5-cyanopyrazin-2-yl)(methyl)amino)piperidine-1- carboxylate (1.50 g, 71%).

Reference： [1]Patent: WO2016/196776,2016,A2 .Location in patent: Paragraph 00851

7
[ 912368-73-1 ]
(S)-tert-butyl-3-(1,1-dioxidobenzo[d]isothiazol-2(3H)-yl)piperidine-1-carboxylate [ No CAS ]

Reference： [1]Patent: WO2018/2437,2018,A1

8
[ 766-39-2 ]
[ 912368-73-1 ]
(S)-tert-butyl 3-(3,4-dimethyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)piperidine-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
6 g	With triethylamine; In toluene; at 20℃; for 16h;Reflux;	To a stirred solution of (S)-tert-butyl 3-(methylamino)piperidine- 1 -carboxylate (5 g, 25 mmol) in toluene (150 ml) was added triethylamine (5.42 ml, 37.5 mmol) followed by 3,4- dimethylfuran-2,5-dione (3.15 g, 2Smmol) at RT and the resulting reaction mixture was heated at reflux temperature for 16 h. The reaction mixture was cooled to RT and dilutedwith EtOAc and washed with water. The organic layer was dried and evaporated. The crude product was purified by flash chromatography to obtain 6.0 g of the product.?H NMR (300 MHz, CDC13) oe ppm 1.45 (s, 9H), 1.65- 1.83 (m, 2H), 1.95 (s, 6H), 2.05 - 2.29 (m, 2H), 2.60 - 2.75 (m, 1H), 3.22-3.35 (m, 1H), 3.92 - 4.10 (m, 3H).

Reference： [1]Patent: WO2018/2437,2018,A1 .Location in patent: Page/Page column 29

9
[ 766-39-2 ]
[ 912368-73-1 ]
(3S)-tert-butyl 3-((3R,4R)-dimethyl-2,5-dioxopyrrolidin-1-yl)piperidine-1-carboxylate [ No CAS ]

Reference： [1]Patent: WO2018/2437,2018,A1

10
[ 912368-73-1 ]
[ 2905-25-1 ]
tert-butyl (3S)-3-[(2-bromophenyl)sulfonyl](methyl)amino}piperidine-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1.2 g	With dmap; triethylamine; In dichloromethane; at 20℃; for 16h;	To an ice cold stirred solution of crude <strong>[912368-73-1](S)-tert-butyl 3-(methylamino)piperidine-1-carboxylate</strong> (3.0 g, 14 mmol) in CH2C12 (100 mL) was added Et3N (2.1 mL, 15.4 mmol),DMAP (342 mg, 2.8 mmol) and 2-bromobenzene-1-sulfonyl chloride (3.9 g, 15.4 mmol) and stirred at rt for 16 h. The reaction mixture was diluted with CH2C12 (100 mL) and washed with water. The organic layer was dried over anhydrous Na2504 and concentrated under reduced pressure. Crude product was purified with silica gel chromatography using 10%EtOAc / petroleum ether to afford 1.2 g of(S)-tert-butyl 3-(2-bromo-N-methylphenyl- sulfonamido)piperidine- 1 -carboxylate as pale yellow thick mass.LC-MS (ES+) [M +1]: 433.5.

Reference： [1]Patent: WO2018/2437,2018,A1 .Location in patent: Page/Page column 99

11
[ 50-00-0 ]
[ 625471-18-3 ]
[ 912368-73-1 ]

Yield	Reaction Conditions	Operation in experiment
3 g		To a stirred solution of aqueous formaldehyde (1.85 ml, 25 mmol, 37%) and molecular sieves in methanol was added (S)-tert-butyl 3-aminopiperidine- 1 -carboxylate (5.0 g, 25 mmol) and reaction was stirred at room temperature for 24 h. Sodium borohydride (1.52 g,40 mmol) was added to the above mixture at room temperature and mixture was stirred for16 h. The reaction mixture was quenched with addition of ice water (30 mL) and thenextracted with EtOAc (3 x 100 mL). Combined organic extracts were dried over anhydrousNa2504 and concentrated to obtain 3.0 g of crude (S)-tert-butyl 3-(methylamino)piperidine-1 -carboxylate as pale yellow liquid. This material was used as such in the next step.?H NMR (400 MHz, CDC13) oe ppm 1.38 (s, 9H), 1.5-1.7 (m, 4H), 1.71-1.90 (m, 2H), 2.18-2.27 (m, 3H), 2.75-2.90 (m, 1H), 3.50-3.92 (m, 2H).

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 1061 - 1073
[2]Patent: WO2018/2437,2018,A1 .Location in patent: Page/Page column 99

12
[ 912368-73-1 ]
C₂₅H₂₈N₄O₂S [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 1061 - 1073

13
[ 912368-73-1 ]
4-{methyl[(3S)-piperidin-3-yl]amino}-2-phenylthieno[3,2-c]pyridine-7-carboxamide [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 1061 - 1073

14
[ 690635-43-9 ]
[ 912368-73-1 ]
C₁₉H₂₃BrN₄O₂S [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 1061 - 1073

15
[ 625471-18-3 ]
[ 912368-73-1 ]

Reference： [1]Patent: WO2006/106326,2006,A1
[2]Bioorganic and Medicinal Chemistry Letters,2019,vol. 29

16
tert-butyl (3S)-3-[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate [ No CAS ]
[ 912368-73-1 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2019,vol. 29

17
tert-butyl (3S)-3-[(benzyloxy)carbonyl](methyl)amino}piperidine-1-carboxylate [ No CAS ]
[ 912368-73-1 ]

Yield	Reaction Conditions	Operation in experiment
1.88 g	With palladium 10% on activated carbon; hydrogen; In methanol; at 20℃; for 5h;	To a solution of tert-butyl (3S)-3-aminopiperidine-1-carboxylate 16a (2.0 g, 10 mmol), Triethylamine in THF (60 mL), Benzyl Chloroformate (1.7 mL, 12 mmol) was added. The mixture was stirred at room temperature fo(1.5 mL, 15 mmol) r 1 h. Then, the mixture was poured into water and extracted with ethyl acetate. The ethyl acetate layer was washed with brine, dried over sodium sulfate, and concentrated in vacuo to give tert-butyl (3S)-3-[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate, which was used for the next reaction without further purification. To a solution of tert-butyl (3S)-3-[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate in THF (120 mL) at 0 C, 63% Sodium hydride (0.35 g, 9.3 mmol) and Iodomethane (1.5 mL, 15 mmol) were added. The mixture was allowed to warm up to room temperature and stirred for 5 h. Then, the mixture was poured into water and extracted with ethyl acetate. The ethyl acetate layer was washed with brine, dried over sodium sulfate, and concentrated in vacuo. The residue was passed through a short pad of silica gel column to give crude tert-butyl (3S)-3-[(benzyloxy)carbonyl](methyl)amino}piperidine-1-carboxylate. To a solution of the compound prepared in the previous step in methanol (60 mL) was added 10 percent palladium-activated carbon (2.0 g), and the resulting mixture was stirred at room temperature for 5 hours under a hydrogen atmosphere. After the catalyst in the reaction mixture was filtered off, and the filtrate was concentrated in vacuo The residue was purified by column chromatography using silica gel (80 g) and eluted with 0-18% methanol in dichloromethane to give the title compound 17a (1.88 g, 88%) as an oil. 1H-NMR (400 MHz, CDCl3) delta: 3.50-3.92 (m, 2H) , 2.75-2.90 (m, 1H),. 2.18-2.27 (m, 3H), 1.71-1.90 (m, 2H), 1.38 (s, 9H) ;13C NMR (100 MHz, DMSO-d6) delta: 153.90, 78.36, 55.39, 48.34, 44.15, 43.44, 33.34, 30.45, 28.03, 23.45, 22.87; HRMS (Positive ESI) m/z 215.1757 (215.1754 calcd for C11H22N2O2 + H); EA Anal. calcd for C11H22N2O2. C, 61.65; H, 10.35; N, 13.07. Found: C, 61.09; H, 10.32; N, 12.57; []D20 : 9.56 (c=1.026, CHCl3).

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2019,vol. 29

18
[ 1477-50-5 ]
[ 912368-73-1 ]
tert-butyl (3S)-3-[(1H-indole-2-carbonyl)(methyl)amino]piperidine-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92%	With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20℃; for 14h;	To a solution of <strong>[912368-73-1]tert-butyl (3S)-3-(methylamino)piperidine-1-carboxylate</strong> 17a (1.0 g, 4.7 mmol) in THF (30 mL), indole-2-carboxylic acid (1.1 g, 7.0 mmol) and 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (1.3 g, 7.0 mmol) were added. The mixture was stirred at room temperature for 14 h. Ethyl acetate was added to the mixture. The solution was washed with saturated aqueous sodium hydrogen carbonate, water, and brine, dried over anhydrous sodium sulfate salt, and concentrated under reduced pressure. The residue was subjected to column chromatography using silica gel (60 g) and eluted with 20-60% ethyl acetate in hexane to obtain the title compound 18a (1.5 g, 92%) as an amorphous compound. 1H-NMR (400 MHz, CDCl3) delta: 9.32 (1H, br s), 7.67 (1H, d, J = 8.2 Hz), 7.43 (1H, d, J = 8.2 Hz), 7.30 (1H, t, J = 7.7 Hz), 7.15 (1H, t, J = 7.7 Hz), 6.86 (1H, s), 5.39-5.31 (1H, m), 3.75-3.55 (2H, m), 3.48-3.20 (5H, m), 2.28-2.02 (4H, m), 1.48 (9H, s) ;13C NMR (100 MHz, DMSO-d6) delta: 162.94, 153.92, 135.79, 130.14, 126.88, 123.23, 121.21, 119.69, 112.05, 104.17, 78.91, 59.69, 43.64, 42.67, 27.97, 27.43, 24.42; HRMS (Positive ESI) m/z 358.2141 (358.2125 calcd for C20H27N3O3 + H); EA Anal. calcd for C20H27N3O3. C,67.20; H, 7.61; N, 11.76. Found: C, 67.03; H, 7.69; N, 11.36; []D20 : -64.15 (c=1.004, CHCl3).

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2019,vol. 29

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
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P103	Read label before use
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Code	Phrase
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Code	Phrase
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P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 912368-73-1 ] {[proInfo.proName]}

Quality Control of [ 912368-73-1 ]

Related Doc. of [ 912368-73-1 ]

Product Details of [ 912368-73-1 ]

Calculated chemistry of [ 912368-73-1 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 912368-73-1 ]

Application In Synthesis of [ 912368-73-1 ]

[ 912368-73-1 ] Synthesis Path-Upstream 1~2

[ 912368-73-1 ] Synthesis Path-Downstream 1~18

Related Functional Groups of [ 912368-73-1 ]

Amines

Related Parent Nucleus of [ 912368-73-1 ]

Piperidines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 912368-73-1 ]

Related Parent Nucleus of
[ 912368-73-1 ]