Name: Veliparib | ABT-888; NSC 737664
Brand: Ambeed
SKU: A164131
Rating: 4.5 (55 reviews)

NCT00770471	Brain and Central Nervous Syst... More >>em Tumors Less <<	Phase 1	Completed	-	United States, Alabama ... More >> UAB Comprehensive Cancer Center Birmingham, Alabama, United States, 35294-3410 United States, California UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States, 94115 United States, Georgia Winship Cancer Institute of Emory University Atlanta, Georgia, United States, 30322 United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, Michigan Josephine Ford Cancer Center at Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, North Carolina Wake Forest University Comprehensive Cancer Center Winston-Salem, North Carolina, United States, 27157-1096 United States, Ohio Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States, 44195 United States, Pennsylvania Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104-4283 UPMC Cancer Centers Pittsburgh, Pennsylvania, United States, 15232 United States, Wisconsin University of Wisconsin Comprehensive Cancer Center Madison, Wisconsin, United States, 53792-6164 Less <<
NCT00526617	Non-hematologic Malignancies ... More >> Metastatic Melanoma Breast Cancer Ovarian Cancer Primary Peritoneal Cancer Fallopian Tube Cancer Hepatocellular Carcinoma Less <<	Phase 1	Completed	-	-
NCT01419548	Neoplasms	Phase 1	Withdrawn	-	United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 United States, Pennsylvania University of Pittsburgh Cancer Center Pittsburgh, Pennsylvania, United States Less <<
NCT02921256	Rectal Adenocarcinoma ... More >> Stage II Rectal Cancer AJCC v7 Stage III Rectal Cancer AJCC v7 Less <<	Phase 2	Recruiting	-	-
NCT01026493	Brain and Central Nervous Syst... More >>em Tumors Less <<	Phase 1 Phase 2	Completed	-	United States, California ... More >> Rebecca and John Moores UCSD Cancer Center La Jolla, California, United States, 92093-0658 Cedars-Sinai Medical Center Los Angeles, California, United States, 90048 United States, Hawaii Leeward Radiation Oncology 'Ewa Beach, Hawaii, United States, 96706 Cancer Research Center of Hawaii Honolulu, Hawaii, United States, 96813 Queen's Cancer Institute at Queen's Medical Center Honolulu, Hawaii, United States, 96813 Hawaii Medical Center - East Honolulu, Hawaii, United States, 96817 United States, Illinois University of Chicago Cancer Research Center Chicago, Illinois, United States, 60637-1470 United States, Kansas CCOP - Kansas City Prairie Village, Kansas, United States, 66208 United States, Kentucky Central Baptist Hospital Lexington, Kentucky, United States, 40503-9985 Louisville Oncology at Norton Cancer Institute - Louisville Louisville, Kentucky, United States, 40202 United States, Mississippi Regional Cancer Center at Singing River Hospital Pascagoula, Mississippi, United States, 39581 United States, Nevada Renown Institute for Cancer at Renown Regional Medical Center Reno, Nevada, United States, 89502 United States, New Hampshire Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire, United States, 03756-0002 United States, New Jersey Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School New Brunswick, New Jersey, United States, 08903 United States, New York Highland Hospital of Rochester Rochester, New York, United States, 14620 James P. Wilmot Cancer Center at University of Rochester Medical Center Rochester, New York, United States, 14642 United States, Oregon Legacy Good Samaritan Hospital & Comprehensive Cancer Center Portland, Oregon, United States, 97210 Less <<
NCT01026493	-		Completed	-	-
NCT01063816	Advanced Solid Tumors	Phase 1	Completed	-	-
NCT00994071	Medulloblastoma ... More >> Pontine Glioma Ependymoma Astrocytoma PNET Less <<	Phase 1	Completed	-	United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT00387608	Leukemia Lymp... More >>homa Unspecified Adult Solid Tumor, Protocol Specific Less <<	Phase 1	Completed	-	United States, Maryland ... More >> Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office Bethesda, Maryland, United States, 20892-1182 Less <<
NCT00553189	Solid Tumors ... More >>Lymphomas Less <<	Phase 1	Completed	-	United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT02032277	Triple Negative Breast Cancer	Phase 3	Active, not recruiting	November 2, 2020	-
NCT00535119	Adult Solid Neoplasm ... More >> BRCA1 Mutation Carrier BRCA2 Mutation Carrier Hereditary Breast and Ovarian Cancer Syndrome Less <<	Phase 1	Completed	-	United States, California ... More >> City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 United States, Georgia Emory University/Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, Pennsylvania Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033-0850 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania, United States, 15232 Less <<
NCT01618357	Breast Cancer	Phase 1	Recruiting	December 31, 2019	United States, Indiana ... More >> Indiana University Health Hospital Recruiting Indianapolis, Indiana, United States, 46202 Contact: Amy Miller 317-278-7614 amym@iu.edu Principal Investigator: Richard Zellars, MD Indiana University Health Melvin and Bren Simon Cancer Center Recruiting Indianapolis, Indiana, United States, 46202 Contact: Amy Miller 317-278-7614 amym@iu.edu Principal Investigator: Richard Zellars, MD Sidney and Lois Eskenazi Hospital Recruiting Indianapolis, Indiana, United States, 46202 Contact: Amy Miller 317-278-7614 amym@iu.edu Spring Mill Medical Center Recruiting Indianapolis, Indiana, United States, 46290 Contact: Amy Miller 317-278-7614 amym@iu.edu Principal Investigator: Richard Zellars, MD United States, Maryland The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Recruiting Baltimore, Maryland, United States, 21231 Contact: Amber Bauchle 317-274-2869 adbauchl@iu.edu Less <<
NCT01113957	Ovarian Cancer	Phase 2	Completed	-	-
NCT02470585	Ovarian Cancer ... More >> Ovarian Neoplasm Less <<	Phase 3	Active, not recruiting	May 28, 2020	-
NCT00989651	Fallopian Tube Carcinosarcoma ... More >> Fallopian Tube Clear Cell Adenocarcinoma Fallopian Tube Endometrioid Adenocarcinoma Fallopian Tube Mucinous Adenocarcinoma Fallopian Tube Serous Neoplasm Fallopian Tube Transitional Cell Carcinoma Fallopian Tube Undifferentiated Carcinoma Ovarian Brenner Tumor Ovarian Carcinosarcoma Ovarian Clear Cell Adenocarcinoma Ovarian Endometrioid Adenocarcinoma Ovarian Mucinous Adenocarcinoma Ovarian Seromucinous Tumor Ovarian Serous Adenocarcinoma Ovarian Transitional Cell Carcinoma Ovarian Undifferentiated Carcinoma Primary Peritoneal Serous Adenocarcinoma Stage IIA Fallopian Tube Cancer AJCC v6 and v7 Stage IIA Ovarian Cancer AJCC V6 and v7 Stage IIB Fallopian Tube Cancer AJCC v6 and v7 Stage IIB Ovarian Cancer AJCC v6 and v7 Stage IIC Fallopian Tube Cancer AJCC v6 and v7 Stage IIC Ovarian Cancer AJCC v6 and v7 Stage IIIA Fallopian Tube Cancer AJCC v7 Stage IIIA Ovarian Cancer AJCC v6 and v7 Stage IIIA Primary Peritoneal Cancer AJCC v7 Stage IIIB Fallopian Tube Cancer AJCC v7 Stage IIIB Ovarian Cancer AJCC v6 and v7 Stage IIIB Primary Peritoneal Cancer AJCC v7 Stage IIIC Fallopian Tube Cancer AJCC v7 Stage IIIC Ovarian Cancer AJCC v6 and v7 Stage IIIC Primary Peritoneal Cancer AJCC v7 Stage IV Fallopian Tube Cancer AJCC v6 and v7 Stage IV Ovarian Cancer AJCC v6 and v7 Stage IV Primary Peritoneal Cancer AJCC v7 Less <<	Phase 1	Active, not recruiting	-	-
NCT00946335	Childhood Atypical Teratoid/Rh... More >>abdoid Tumor Childhood Central Nervous System Germ Cell Tumor Childhood Choroid Plexus Tumor Childhood Craniopharyngioma Childhood Ependymoblastoma Childhood Grade I Meningioma Childhood Grade II Meningioma Childhood Grade III Meningioma Childhood High-grade Cerebellar Astrocytoma Childhood High-grade Cerebral Astrocytoma Childhood Infratentorial Ependymoma Childhood Low-grade Cerebellar Astrocytoma Childhood Low-grade Cerebral Astrocytoma Childhood Medulloepithelioma Childhood Mixed Glioma Childhood Oligodendroglioma Childhood Supratentorial Ependymoma Recurrent Childhood Brain Stem Glioma Recurrent Childhood Brain Tumor Recurrent Childhood Cerebellar Astrocytoma Recurrent Childhood Cerebral Astrocytoma Recurrent Childhood Ependymoma Recurrent Childhood Medulloblastoma Recurrent Childhood Pineoblastoma Recurrent Childhood Spinal Cord Neoplasm Recurrent Childhood Subependymal Giant Cell Astrocytoma Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor Recurrent Childhood Visual Pathway and Hypothalamic Glioma Less <<	Phase 1	Completed	-	United States, Tennessee ... More >> Pediatric Brain Tumor Consortium Memphis, Tennessee, United States, 38105 Less <<
NCT01818063	Estrogen Receptor-negative Bre... More >>ast Cancer HER2-negative Breast Cancer Progesterone Receptor-negative Breast Cancer Stage II Breast Cancer Stage IIIA Breast Cancer Stage IIIB Breast Cancer Stage IIIC Breast Cancer Triple-negative Breast Cancer Less <<	Phase 2	Active, not recruiting	April 30, 2019	United States, Maryland ... More >> Walter Reed National Military Medical Center Bethesda, Maryland, United States, 20889 United States, Pennsylvania Thomas Jefferson University Philadelphia, Pennsylvania, United States, 19107 Reading Hospital Reading, Pennsylvania, United States, 19611 Less <<
NCT01818063	-		Active, not recruiting	-	-
NCT01266447	-		Completed	-	-
NCT01445522	Neoplasms Lym... More >>phoma Less <<	Phase 1	Completed	-	United States, California ... More >> City of Hope National Medical Center Duarte, California, United States, 91010 United States, Maryland National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT01085422	Prostate Cancer	Phase 1	Completed	-	-
NCT00740805	Ann Arbor Stage III Non-Hodgki... More >>n Lymphoma Ann Arbor Stage IV Non-Hodgkin Lymphoma Solid Neoplasm Less <<	Phase 1	Active, not recruiting	-	United States, New Jersey ... More >> Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 Less <<
NCT02890355	Metastatic Pancreatic Adenocar... More >>cinoma Recurrent Pancreatic Carcinoma Stage IV Pancreatic Cancer AJCC v6 and v7 Less <<	Phase 2	Active, not recruiting	-	-
NCT00576654	Advanced Malignant Solid Neopl... More >>asm Estrogen Receptor Negative HER2/Neu Negative Hodgkin Lymphoma Metastatic Malignant Neoplasm Metastatic Malignant Solid Neoplasm Non-Hodgkin Lymphoma Progesterone Receptor Negative Stage III Breast Cancer AJCC v7 Stage III Colon Cancer AJCC v7 Stage III Lung Cancer AJCC v7 Stage III Ovarian Cancer AJCC v6 and v7 Stage III Pancreatic Cancer AJCC v6 and v7 Stage IIIA Breast Cancer AJCC v7 Stage IIIA Colon Cancer AJCC v7 Stage IIIA Ovarian Cancer AJCC v6 and v7 Stage IIIB Breast Cancer AJCC v7 Stage IIIB Colon Cancer AJCC v7 Stage IIIB Ovarian Cancer AJCC v6 and v7 Stage IIIC Breast Cancer AJCC v7 Stage IIIC Colon Cancer AJCC v7 Stage IIIC Ovarian Cancer AJCC v6 and v7 Stage IV Breast Cancer AJCC v6 and v7 Stage IV Colon Cancer AJCC v7 Stage IV Lung Cancer AJCC v7 Stage IV Ovarian Cancer AJCC v6 and v7 Stage IV Pancreatic Cancer AJCC v6 and v7 Stage IVA Colon Cancer AJCC v7 Stage IVB Colon Cancer AJCC v7 Triple-Negative Breast Carcinoma Unresectable Malignant Neoplasm Unresectable Solid Neoplasm Less <<	Phase 1	Active, not recruiting	-	United States, Connecticut ... More >> Yale University New Haven, Connecticut, United States, 06520 United States, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, Michigan Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201 Less <<
NCT01051596	Colorectal Cancer	Phase 2	Completed	-	United States, District of Col... More >>umbia Georgetown University Medical Center Washington, District of Columbia, United States, 20008 Less <<
NCT01266447	Cervical Adenocarcinoma ... More >> Cervical Adenosquamous Carcinoma Cervical Small Cell Carcinoma Cervical Squamous Cell Carcinoma Recurrent Cervical Carcinoma Stage III Cervical Cancer Stage IVA Cervical Cancer Stage IVB Cervical Cancer Less <<	Phase 2	Completed	-	-
NCT01638546	Recurrent Small Cell Lung Carc... More >>inoma Less <<	Phase 2	Completed	-	United States, Florida ... More >> Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, Georgia Emory University/Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, Maryland Johns Hopkins Bayview Medical Center Baltimore, Maryland, United States, 21224 Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, North Carolina UNC Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina, United States, 27599 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 United States, Virginia Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia, United States, 23298 Less <<
NCT00804908	-		Completed	-	-
NCT01617928	Solid Tumors	Phase 1	Completed	-	Japan ... More >> Site Reference ID/Investigator# 68622 Tokyo, Japan Less <<
NCT01251874	BRCA1 Gene Mutation ... More >> BRCA2 Gene Mutation Estrogen Receptor Negative Estrogen Receptor Positive HER2/Neu Negative Progesterone Receptor Negative Progesterone Receptor Positive Recurrent Breast Carcinoma Stage IIIB Breast Cancer AJCC v7 Stage IIIC Breast Cancer AJCC v7 Stage IV Breast Cancer AJCC v6 and v7 Triple-Negative Breast Carcinoma Less <<	Phase 1	Completed	-	United States, New York ... More >> Montefiore Medical Center-Einstein Campus Bronx, New York, United States, 10461 Montefiore Medical Center - Moses Campus Bronx, New York, United States, 10467 United States, Ohio Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 Less <<
NCT01459380	Ovarian Clear Cell Cystadenoca... More >>rcinoma Ovarian Endometrioid Adenocarcinoma Ovarian Seromucinous Carcinoma Ovarian Serous Cystadenocarcinoma Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Undifferentiated Ovarian Carcinoma Less <<	Phase 1	Completed	-	United States, Colorado ... More >> University of Colorado Cancer Center - Anschutz Cancer Pavilion Aurora, Colorado, United States, 80045 United States, Georgia Augusta University Medical Center Augusta, Georgia, United States, 30912 United States, Illinois University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 United States, Iowa University of Iowa/Holden Comprehensive Cancer Center Iowa City, Iowa, United States, 52242 United States, Maryland Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 Hillcrest Hospital Cancer Center Mayfield Heights, Ohio, United States, 44124 United States, Oklahoma University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma, United States, 73104 United States, Rhode Island Women and Infants Hospital Providence, Rhode Island, United States, 02905 United States, Wisconsin Froedtert and the Medical College of Wisconsin Milwaukee, Wisconsin, United States, 53226 Less <<
NCT00804908	Melanoma Meta... More >>static Melanoma Skin Cancer Less <<	Phase 2	Completed	-	-
NCT01306032	-		Completed	-	-
NCT01306032	Ovarian Cancer ... More >> Primary Peritoneal Cancer Serous Carcinoma Cancer Triple-Negative Breast Cancer Fallopian Tube Cancer Less <<	Phase 2	Completed	-	United States, California ... More >> University of California, Davis Davis, California, United States, 95616 United States, Florida H. Lee Moffitt Cancer Center & Research Institute Tampa, Florida, United States, 33612 United States, Illinois University of Chicago Chicago, Illinois, United States, 60637 United States, Maryland National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 United States, Minnesota Mayo Clinic, Rochester Rochester, Minnesota, United States, 55905 United States, New York Montefiore Medical Center Bronx, New York, United States, 10467 Memorial Sloan Kettering Cancer Center New York, New York, United States, 10021 United States, Ohio Ohio State University Columbus, Ohio, United States, 43210-1240 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77030-4096 Canada, Ontario Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT01638546	-		Completed	-	-
NCT02152982	Glioblastoma ... More >>Gliosarcoma Less <<	Phase 2 Phase 3	Active, not recruiting	-	-
NCT01642251	Extensive Stage Small Cell Lun... More >>g Carcinoma Large Cell Lung Carcinoma Neuroendocrine Carcinoma Small Cell Carcinoma Stage IV Non-Small Cell Lung Cancer AJCC v7 Less <<	Phase 1 Phase 2	Active, not recruiting	-	-
NCT02305758	Untreated Metastatic Colorecta... More >>l Cancer Less <<	Phase 2	Completed	-	-
NCT00649207	Brain Diseases ... More >> Brain Neoplasms Central Nervous System Diseases Neoplasm Metastasis Nervous System Neoplasms Less <<	Phase 1	Completed	-	United States, Georgia ... More >> Site Reference ID/Investigator# 8334 Atlanta, Georgia, United States, 30322 United States, Illinois Site Reference ID/Investigator# 52462 Chicago, Illinois, United States, 60611 United States, Kansas Site Reference ID/Investigator# 24483 Kansas City, Kansas, United States, 66160 United States, Maryland Site Reference ID/Investigator# 7180 Baltimore, Maryland, United States, 21231-2410 United States, Michigan Site Reference ID/Investigator# 19021 Detroit, Michigan, United States, 48202-2689 United States, Pennsylvania Site Reference ID/Investigator# 6344 Philadelphia, Pennsylvania, United States, 19111 United States, Wisconsin Site Reference ID/Investigator# 6653 Madison, Wisconsin, United States, 53792 Canada Site Reference ID/Investigator# 18542 Toronto, Canada, M5G 2M9 Puerto Rico Site Reference ID/Investigator# 46322 Ponce, Puerto Rico, 00716 Less <<
NCT02831179	Functional Pancreatic Neuroend... More >>ocrine Tumor Malignant Somatostatinoma Merkel Cell Carcinoma Metastatic Adrenal Gland Pheochromocytoma Metastatic Carcinoid Tumor Multiple Endocrine Neoplasia Type 1 Multiple Endocrine Neoplasia Type 2A Multiple Endocrine Neoplasia Type 2B Neuroendocrine Neoplasm Non-Functional Pancreatic Neuroendocrine Tumor Pancreatic Glucagonoma Pancreatic Insulinoma Recurrent Adrenal Cortex Carcinoma Recurrent Adrenal Gland Pheochromocytoma Recurrent Merkel Cell Carcinoma Somatostatin-Producing Neuroendocrine Tumor Stage III Adrenal Cortex Carcinoma Stage III Thyroid Gland Medullary Carcinoma Stage IIIA Merkel Cell Carcinoma Stage IIIB Merkel Cell Carcinoma Stage IV Adrenal Cortex Carcinoma Stage IV Merkel Cell Carcinoma Stage IVA Thyroid Gland Medullary Carcinoma Stage IVB Thyroid Gland Medullary Carcinoma Stage IVC Thyroid Gland Medullary Carcinoma Thymic Carcinoid Tumor VIP-Producing Neuroendocrine Tumor Well Differentiated Adrenal Cortex Carcinoma Zollinger Ellison Syndrome Less <<	Phase 1	Withdrawn(Loss of funding supp... More >>ort) Less <<	February 2020	-
NCT01154426	Adult Solid Neoplasm ... More >> BRCA1 Mutation Carrier BRCA2 Mutation Carrier Less <<	Phase 1	Completed	-	United States, Pennsylvania ... More >> Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033-0850 UPMC-Magee Womens Hospital Pittsburgh, Pennsylvania, United States, 15213 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania, United States, 15232 Less <<
NCT01711541	Head and Neck Squamous Cell Ca... More >>rcinoma Stage IVA Oropharyngeal Carcinoma AJCC v7 Stage IVB Oropharyngeal Carcinoma AJCC v7 Less <<	Phase 1 Phase 2	Active, not recruiting	-	United States, Illinois ... More >> Northwestern University Chicago, Illinois, United States, 60611 University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois, United States, 60201 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, North Carolina UNC Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina, United States, 27599 Less <<
NCT03400306	Cancer - Ovarian	Phase 1	Not yet recruiting	May 24, 2022	United States, Michigan ... More >> Karmanos Cancer Center /ID# 200136 Not yet recruiting Detroit, Michigan, United States, 48201 United States, Oklahoma University of Oklahoma /ID# 171276 Not yet recruiting Tulsa, Oklahoma, United States, 74135-2527 United States, Rhode Island Lifespan Cancer Institute /ID# 200130 Not yet recruiting Providence, Rhode Island, United States, 02903-4923 United States, Utah Huntsman Cancer Institute /ID# 200135 Not yet recruiting Salt Lake City, Utah, United States, 84112-5500 Denmark Herlev Hospital /ID# 201073 Not yet recruiting Herlev, Hovedstaden, Denmark, 2730 Netherlands Antoni van Leeuwenhoek /ID# 202356 Not yet recruiting Amsterdam, Noord-Holland, Netherlands, 1066 CX Erasmus Medisch Centrum /ID# 201555 Not yet recruiting Rotterdam, Netherlands, 3015 CE Less <<
NCT02985658	-		-	-	United States, Washington ... More >> Seattle Cancer Care Allliance Seattle, Washington, United States, 98109 Contact: Jennifer Specht, MD 206-606-6329 Less <<
NCT02305758	-		Completed	-	-
NCT03289910	Acute Myeloid Leukemia ... More >> Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative Chronic Myelomonocytic Leukemia Essential Thrombocythemia Myelodysplastic/Myeloproliferative Neoplasm Myelofibrosis Polycythemia Vera Recurrent Adult Acute Myeloid Leukemia Refractory Acute Myeloid Leukemia Less <<	Phase 2	Recruiting	June 1, 2020	United States, Maryland ... More >> Johns Hopkins University/Sidney Kimmel Cancer Center Recruiting Baltimore, Maryland, United States, 21287 Contact: Site Public Contact 410-955-8804 jhcccro@jhmi.edu Principal Investigator: Keith W. Pratz Less <<
NCT01576172	Castration Levels of Testoster... More >>one Castration-Resistant Prostate Carcinoma PSA Progression Recurrent Prostate Carcinoma Stage IV Prostate Cancer AJCC v7 Less <<	Phase 2	Active, not recruiting	-	United States, California ... More >> City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 City of Hope South Pasadena South Pasadena, California, United States, 91030 United States, Illinois University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois, United States, 60201 United States, Indiana Indiana University/Melvin and Bren Simon Cancer Center Indianapolis, Indiana, United States, 46202 United States, Maryland Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 United States, Michigan University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 United States, New Jersey Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 United States, North Carolina UNC Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina, United States, 27599 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 United States, Washington University of Washington Medical Center Seattle, Washington, United States, 98195 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Less <<
NCT01506609	Metastatic Breast Cancer	Phase 2	Active, not recruiting	May 30, 2019	-
NCT01386385	Large Cell Lung Carcinoma ... More >> Lung Adenocarcinoma Lung Adenocarcinoma, Mixed Subtype Minimally Invasive Lung Adenocarcinoma Squamous Cell Lung Carcinoma Stage III Non-Small Cell Lung Cancer AJCC v7 Stage IIIA Non-Small Cell Lung Cancer AJCC v7 Stage IIIB Lung Non-Small Cell Cancer AJCC v7 Less <<	Phase 1 Phase 2	Active, not recruiting	January 2, 2021	-
NCT01281852	Cervical Adenocarcinoma ... More >> Cervical Adenosquamous Carcinoma Cervical Squamous Cell Carcinoma, Not Otherwise Specified Recurrent Cervical Carcinoma Stage IVB Cervical Cancer Less <<	Phase 1	Completed	-	-
NCT01281150	Adult Solid Neoplasm ... More >> Estrogen Receptor Negative Estrogen Receptor Positive HER2/Neu Negative Male Breast Carcinoma Progesterone Receptor Negative Recurrent Breast Carcinoma Stage IIIB Breast Cancer Stage IIIC Breast Cancer Stage IV Breast Cancer Triple-Negative Breast Carcinoma Less <<	Phase 1	Completed	-	United States, Pennsylvania ... More >> Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033-0850 UPMC-Magee Womens Hospital Pittsburgh, Pennsylvania, United States, 15213 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 Less <<
NCT02264990	Non-squamous Non-small Cell Lu... More >>ng Cancer Less <<	Phase 3	Active, not recruiting	July 26, 2019	-
NCT01012817	Metastatic Malignant Solid Neo... More >>plasm Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Unresectable Solid Neoplasm Less <<	Phase 1 Phase 2	Suspended(Other - assess toxic... More >>ity and perform interim analysis.) Less <<	-	United States, Arizona ... More >> Mayo Clinic Hospital Phoenix, Arizona, United States, 85054 Mayo Clinic in Arizona Scottsdale, Arizona, United States, 85259 United States, California University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 United States, Colorado University of Colorado Hospital Aurora, Colorado, United States, 80045 United States, Florida Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 United States, Illinois University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 UC Comprehensive Cancer Center at Silver Cross New Lenox, Illinois, United States, 60451 University of Chicago Medicine-Orland Park Orland Park, Illinois, United States, 60462 United States, Kansas University of Kansas Clinical Research Center Fairway, Kansas, United States, 66205 United States, Kentucky University of Kentucky/Markey Cancer Center Lexington, Kentucky, United States, 40536 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Pennsylvania University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 United States, Texas Parkland Memorial Hospital Dallas, Texas, United States, 75235 UT Southwestern/Simmons Cancer Center-Dallas Dallas, Texas, United States, 75390 United States, Utah Huntsman Cancer Institute/University of Utah Salt Lake City, Utah, United States, 84112 Less <<
NCT03227016	Small Cell Lung Cancer SCLC	Phase 1	Recruiting	August 2020	Germany ... More >> Klinik München Gauting Recruiting München Gauting, Germany Contact: Joachim von Pawel, MD Less <<
NCT02033551	Breast Cancer ... More >> Ovarian Cancer Colon Cancer Lung Cancer Gastric Cancer Solid Tumors Less <<	Phase 1	Completed	-	United States, Arizona ... More >> Site Reference ID/Investigator# 117416 Scottsdale, Arizona, United States, 85258 United States, Texas Site Reference ID/Investigator# 117415 San Antonio, Texas, United States, 78229 Netherlands Site Reference ID/Investigator# 117337 Groningen, Netherlands, 9713 GZ Site Reference ID/Investigator# 117338 Maastricht, Netherlands, 6229 HX Spain Site Reference ID/Investigator# 117451 Madrid, Spain, 28050 Less <<
NCT01749397	Stage IV Fallopian Tube Cancer... More >> AJCC v6 and v7 Stage IV Ovarian Cancer AJCC v6 and v7 Stage IV Primary Peritoneal Cancer AJCC v7 Less <<	Phase 1	Active, not recruiting	-	United States, Arizona ... More >> Mayo Clinic in Arizona Scottsdale, Arizona, United States, 85259 United States, Maryland Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Missouri Siteman Cancer Center at Washington University Saint Louis, Missouri, United States, 63110 Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Less <<
NCT01514201	Anaplastic Astrocytoma ... More >> Brain Stem Glioma Childhood Mixed Glioma Fibrillary Astrocytoma Giant Cell Glioblastoma Glioblastoma Gliosarcoma Untreated Childhood Anaplastic Astrocytoma Untreated Childhood Brain Stem Glioma Untreated Childhood Fibrillary Astrocytoma Untreated Childhood Giant Cell Glioblastoma Untreated Childhood Glioblastoma Untreated Childhood Gliosarcoma Less <<	Phase 1 Phase 2	Completed	-	United States, California ... More >> Children's Hospital Los Angeles Los Angeles, California, United States, 90027 Lucile Packard Children's Hospital Stanford University Palo Alto, California, United States, 94304 United States, District of Columbia Children's National Medical Center Washington, District of Columbia, United States, 20010 United States, Illinois Lurie Children's Hospital-Chicago Chicago, Illinois, United States, 60611 United States, Maryland National Institutes of Health Clinical Center Bethesda, Maryland, United States, 20892 United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 United States, Pennsylvania Children's Hospital of Pittsburgh of UPMC Pittsburgh, Pennsylvania, United States, 15224 United States, Tennessee Pediatric Brain Tumor Consortium Memphis, Tennessee, United States, 38105 St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 United States, Texas Texas Children's Hospital Houston, Texas, United States, 77030 Less <<
NCT01326702	Adult B Acute Lymphoblastic Le... More >>ukemia Adult Nasal Type Extranodal NK/T-Cell Lymphoma Adult Solid Neoplasm Anaplastic Large Cell Lymphoma Angioimmunoblastic T-Cell Lymphoma Chronic Lymphocytic Leukemia Cutaneous B-Cell Non-Hodgkin Lymphoma Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue Hepatosplenic T-Cell Lymphoma Intraocular Lymphoma Lymphomatous Involvement of Non-Cutaneous Extranodal Site Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma Nodal Marginal Zone Lymphoma Recurrent Adult Acute Lymphoblastic Leukemia Recurrent Adult Burkitt Lymphoma Recurrent Adult Diffuse Large Cell Lymphoma Recurrent Adult Diffuse Mixed Cell Lymphoma Recurrent Adult Diffuse Small Cleaved Cell Lymphoma Recurrent Adult Grade III Lymphomatoid Granulomatosis Recurrent Adult Hodgkin Lymphoma Recurrent Adult Immunoblastic Lymphoma Recurrent Adult Lymphoblastic Lymphoma Recurrent Adult T-Cell Leukemia/Lymphoma Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma Recurrent Grade 1 Follicular Lymphoma Recurrent Grade 2 Follicular Lymphoma Recurrent Grade 3 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Recurrent Marginal Zone Lymphoma Recurrent Mycosis Fungoides and Sezary Syndrome Recurrent Small Lymphocytic Lymphoma Refractory Chronic Lymphocytic Leukemia Refractory Hairy Cell Leukemia Refractory Plasma Cell Myeloma Small Intestinal Lymphoma Splenic Marginal Zone Lymphoma Testicular Lymphoma Waldenstrom Macroglobulinemia Less <<	Phase 1 Phase 2	Completed	-	United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Less <<
NCT01489865	Metastatic Pancreatic Cancer	Phase 1 Phase 2	Recruiting	December 2019	United States, District of Col... More >>umbia Georgetown Lombardi Comprehensive Cancer Center Recruiting Washington, District of Columbia, United States, 20007 Contact: Sarah Parenti 202-687-8350 sep88@georgetown.edu Contact: Lisa Ley, RN MSN 202-687-6653 leyl@georgetown.edu Principal Investigator: Michael Pishvaian, MD PhD Less <<
NCT01560104	Non-Small -Cell Lung Cancer	Phase 2	Completed	-	-
NCT01264432	Adult Solid Neoplasm ... More >> Peritoneal Carcinomatosis Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Less <<	Phase 1	Completed	-	United States, Maryland ... More >> University of Maryland/Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 Canada, Ontario University Health Network-Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT01585805	BRCA1 Gene Mutation ... More >> BRCA2 Gene Mutation Metastatic Pancreatic Adenocarcinoma PALB2 Gene Mutation Pancreatic Adenocarcinoma Recurrent Pancreatic Carcinoma Stage III Pancreatic Cancer AJCC v6 and v7 Stage IV Pancreatic Cancer AJCC v6 and v7 Less <<	Phase 2	Recruiting	-	United States, Illinois ... More >> University of Chicago Comprehensive Cancer Center Recruiting Chicago, Illinois, United States, 60637 Contact: Hedy L. Kindler 773-702-0360 hkindler@medicine.bsd.uchicago.edu Principal Investigator: Hedy L. Kindler Ingalls Memorial Hospital Recruiting Harvey, Illinois, United States, 60426 Contact: Mark F. Kozloff 708-339-4800 mkozloff@bsd.uchicago.edu Principal Investigator: Mark F. Kozloff United States, Michigan University of Michigan Comprehensive Cancer Center Recruiting Ann Arbor, Michigan, United States, 48109 Contact: Mark M. Zalupski 734-615-3969 zalupski@umich.edu Principal Investigator: Mark M. Zalupski United States, Missouri Mercy Hospital Saint Louis Completed Saint Louis, Missouri, United States, 63141 United States, New Jersey Memorial Sloan Kettering Basking Ridge Recruiting Basking Ridge, New Jersey, United States, 07920 Contact: Han Xiao 212-639-7202 Sub-Investigator: Han Xiao Sub-Investigator: Sree B. Chalasani Sub-Investigator: Afsheen Iqbal United States, New York Memorial Sloan Kettering Commack Recruiting Commack, New York, United States, 11725 Contact: Jahan Aghalar 212-639-7202 Sub-Investigator: Jahan Aghalar Sub-Investigator: Avni M. Desai Sub-Investigator: Juliana W. Eng Sub-Investigator: John J. Fiore Sub-Investigator: Stuart M. Lichtman Memorial Sloan Kettering Westchester Recruiting Harrison, New York, United States, 10604 Contact: Parisa Momtaz kashanie@mskcc.org Sub-Investigator: Parisa Momtaz Sub-Investigator: Philip C. Caron Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Eileen M. O'Reilly 646-888-4182 oreillye@mskcc.org Principal Investigator: Eileen M. O'Reilly Memorial Sloan Kettering Rockville Centre Recruiting Rockville Centre, New York, United States, 11570 Contact: Arlyn J. Apollo 212-639-7202 Sub-Investigator: Arlyn J. Apollo Sub-Investigator: Pamela R. Drullinsky Sub-Investigator: Zoe Goldberg Sub-Investigator: Kenneth K. Ng Sub-Investigator: Tiffany Troso-Sandoval Canada, Ontario University Health Network-Princess Margaret Hospital Recruiting Toronto, Ontario, Canada, M5G 2M9 Contact: Neesha Dhani 416-946-4501 neesha.dhani@uhn.ca Principal Investigator: Neesha Dhani Israel Shaare Zedek Medical Center Recruiting Jerusalem, Israel, 91031 Contact: Amiel Segal 972-2-666-6331 segal@szmc.org.il Principal Investigator: Amiel Segal Chaim Sheba Medical Center Recruiting Tel Hashomer, Israel, 52621 Contact: Talia Golan 972-3-530-3030 tailia.golan@sheba.health.gov.il Principal Investigator: Talia Golan Less <<
NCT01366144	Breast Carcinoma ... More >> Carcinoma of Unknown Primary Origin Endometrial Carcinoma Esophageal Carcinoma Lung Carcinoma Malignant Head and Neck Neoplasm Melanoma Ovarian Carcinoma Renal Pelvis and Ureter Urothelial Carcinoma Testicular Lymphoma Less <<	Phase 1	Suspended(Other - Per CTEP Act... More >>ion Letter) Less <<	-	United States, California ... More >> City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 City of Hope South Pasadena South Pasadena, California, United States, 91030 United States, Florida Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, Georgia Emory University Hospital/Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, Maryland Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 United States, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, Michigan Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, New Jersey Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 United States, New York Montefiore Medical Center-Weiler Hospital Bronx, New York, United States, 10461 Montefiore Medical Center - Moses Campus Bronx, New York, United States, 10467 Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 United States, Pennsylvania Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033-0850 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Less <<
NCT01205828	Hepatocellular Carcinoma	Phase 2	Terminated(Lack of efficacy)	-	United States, District of Col... More >>umbia Lombardi Comprehensive Cancer Center at Georgetown University Medical Center Washington, District of Columbia, United States, 20007 Less <<
NCT01495351	Multiple Myeloma	Phase 1	Completed	-	Canada, Alberta ... More >> Tom Baker Cancer Centre Calgary, Alberta, Canada, T2N 4N2 Less <<
NCT01477489	Breast Cancer	Phase 1	Completed	-	United States, Massachusetts ... More >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 United States, North Carolina Duke Durham, North Carolina, United States, 27710 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT02009631	Breast Cancer ... More >> Ovarian Cancer Colon Cancer Lung Cancer Gastric Cancer Solid Tumors Less <<	Phase 1	Completed	-	United States, Arizona ... More >> Site Reference ID/Investigator# 116015 Scottsdale, Arizona, United States, 85258 United States, Texas Site Reference ID/Investigator# 116016 San Antonio, Texas, United States, 78229 Netherlands Site Reference ID/Investigator# 117320 Groningn, Netherlands, 9713 GZ Site Reference ID/Investigator# 117336 Maastricht, Netherlands, 6229 HX Spain Site Reference ID/Investigator# 117517 Madrid, Spain, 28050 Less <<
NCT01017640	Solid Neoplasm	Phase 1	Completed	-	United States, Kentucky ... More >> Georgetown Cancer Treatment Center Georgetown, Kentucky, United States, 40324 United States, Ohio Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 Less <<
NCT00588991	Adult Acute Megakaryoblastic L... More >>eukemia Adult Acute Monoblastic Leukemia Adult Acute Monocytic Leukemia Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11 Adult Acute Myeloid Leukemia With Maturation Adult Acute Myeloid Leukemia With Minimal Differentiation Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11 Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1 Adult Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A Adult Acute Myeloid Leukemia Without Maturation Adult Acute Myelomonocytic Leukemia Adult Erythroleukemia Adult Pure Erythroid Leukemia Chronic Myelomonocytic Leukemia de Novo Myelodysplastic Syndrome Essential Thrombocythemia Hematopoietic and Lymphoid Cell Neoplasm Myelodysplastic Syndrome Philadelphia Chromosome Negative, BCR-ABL1 Positive Chronic Myelogenous Leukemia Polycythemia Vera Previously Treated Myelodysplastic Syndrome Recurrent Adult Acute Lymphoblastic Leukemia Recurrent Adult Acute Myeloid Leukemia Recurrent Disease Secondary Myelodysplastic Syndrome Less <<	Phase 1	Active, not recruiting	-	United States, Maryland ... More >> Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT01145430	Estrogen Receptor Negative ... More >> HER2/Neu Negative Male Breast Carcinoma Progesterone Receptor Negative Recurrent Breast Carcinoma Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Stage IV Breast Cancer AJCC v6 and v7 Triple-Negative Breast Carcinoma Less <<	Phase 1	Completed	-	United States, New York ... More >> Montefiore Medical Center-Einstein Campus Bronx, New York, United States, 10461 Montefiore Medical Center - Moses Campus Bronx, New York, United States, 10467-2490 Laura and Isaac Perlmutter Cancer Center at NYU Langone New York, New York, United States, 10016 Mount Sinai Hospital New York, New York, United States, 10029 Columbia University/Herbert Irving Cancer Center New York, New York, United States, 10032 Weill Medical College of Cornell University New York, New York, United States, 10065 Less <<
NCT01104259	Estrogen Receptor-negative Bre... More >>ast Cancer HER2-negative Breast Cancer Hereditary Breast/Ovarian Cancer - BRCA1 Hereditary Breast/Ovarian Cancer - BRCA2 Male Breast Cancer Progesterone Receptor-negative Breast Cancer Recurrent Breast Cancer Stage IV Breast Cancer Triple-negative Breast Cancer Less <<	Phase 1	Completed	-	United States, Washington ... More >> Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium Seattle, Washington, United States, 98109 Less <<
NCT01205828	-		Terminated(Lack of efficacy)	-	-
NCT01282333	Advanced Adult Primary Liver C... More >>ancer Localized Unresectable Adult Primary Liver Cancer Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter Regional Transitional Cell Cancer of the Renal Pelvis and Ureter Stage III Bladder Cancer Stage III Pancreatic Cancer Stage IIIA Non-small Cell Lung Cancer Stage IIIB Non-small Cell Lung Cancer Stage IV Bladder Cancer Stage IV Non-small Cell Lung Cancer Stage IV Pancreatic Cancer Transitional Cell Carcinoma of the Bladder Unresectable Extrahepatic Bile Duct Cancer Unresectable Gallbladder Cancer Less <<	Phase 1	Terminated	-	United States, Massachusetts ... More >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Pennsylvania Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033-0850 University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15232 Less <<
NCT02163694	Metastatic Breast Cancer	Phase 3	Active, not recruiting	May 30, 2019	-
NCT01139970	Accelerated Phase of Disease ... More >> Acute Lymphoblastic Leukemia Acute Myeloid Leukemia Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11 Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11 Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1 Adult Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A Adult Acute Promyelocytic Leukemia With PML-RARA Adult B Acute Lymphoblastic Leukemia Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 Adult T Acute Lymphoblastic Leukemia Alkylating Agent-Related Acute Myeloid Leukemia Blastic Phase Chronic Myelomonocytic Leukemia Recurrent Adult Acute Lymphoblastic Leukemia Recurrent Adult Acute Myeloid Leukemia Recurrent Disease Secondary Acute Myeloid Leukemia Untreated Adult Acute Lymphoblastic Leukemia Untreated Adult Acute Myeloid Leukemia Less <<	Phase 1	Active, not recruiting	-	United States, Illinois ... More >> University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 United States, Maryland University of Maryland/Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 Less <<
NCT02106546	Squamous Non-Small Cell Lung C... More >>ancer Less <<	Phase 3	Active, not recruiting	July 15, 2019	-
NCT01149083	BRCA1 Mutation Carrier ... More >> BRCA2 Mutation Carrier Recurrent Breast Carcinoma Stage IIIB Breast Cancer AJCC v7 Stage IIIC Breast Cancer AJCC v7 Stage IV Breast Cancer AJCC v6 and v7 Less <<	Phase 2	Active, not recruiting	-	United States, California ... More >> City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 United States, Colorado University of Colorado Hospital Aurora, Colorado, United States, 80045 United States, Florida Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 United States, Illinois University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 United States, Maryland Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 United States, Massachusetts Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Missouri Siteman Cancer Center at Washington University Saint Louis, Missouri, United States, 63110 Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, New York Montefiore Medical Center-Einstein Campus Bronx, New York, United States, 10461 Montefiore Medical Center - Moses Campus Bronx, New York, United States, 10467 Laura and Isaac Perlmutter Cancer Center at NYU Langone New York, New York, United States, 10016 Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Weill Medical College of Cornell University New York, New York, United States, 10065 United States, Pennsylvania Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033-0850 UPMC-Magee Womens Hospital Pittsburgh, Pennsylvania, United States, 15213 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 Canada, Ontario University Health Network-Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT02944396	Non-Small Cell Lung Cancer	Phase 1 Phase 2	Active, not recruiting	January 2, 2019	United States, Alabama ... More >> University of Alabama /ID# 155135 Birmingham, Alabama, United States, 35233 United States, California Icri /Id# 155593 Whittier, California, United States, 90603 United States, Colorado Univ of Colorado Cancer Center /ID# 153820 Aurora, Colorado, United States, 80045 United States, Illinois University of Chicago /ID# 153824 Chicago, Illinois, United States, 60637-1443 United States, Indiana Goshen Center for Cancer Care /ID# 153822 Goshen, Indiana, United States, 46526 United States, North Carolina Duke Univ Med Ctr /ID# 153821 Durham, North Carolina, United States, 27710 Less <<
NCT03061188	Advanced Solid Neoplasm ... More >> Aggressive Non-Hodgkin Lymphoma Recurrent Solid Neoplasm Refractory Mantle Cell Lymphoma T-Cell Non-Hodgkin Lymphoma Unresectable Solid Neoplasm Less <<	Phase 1	Recruiting	January 2021	United States, Illinois ... More >> Northwestern University Recruiting Chicago, Illinois, United States, 60611 Contact: Young K. Chae, MD, MPH, MBA 312-695-0370 Principal Investigator: Young K. Chae, MD, MPH, MBA Sub-Investigator: Benedito Carneiro, MD Sub-Investigator: Sunandana Chandra, MD Sub-Investigator: Jason Kaplan, MD Sub-Investigator: Aparna Kalyan, MD Sub-Investigator: Sarika Jain, MD Sub-Investigator: Massimo Cristofanilli, MD Sub-Investigator: Victoria Villaflor, MD Sub-Investigator: Cesar Santa-Maria, MD Sub-Investigator: Ricardo Costa, MD Sub-Investigator: Valerie Nelson, MD Sub-Investigator: Neal Christiansen, MD Sub-Investigator: Alok Pant, MD Sub-Investigator: Amanda Williams, PA Sub-Investigator: Hannah Garret, APN Sub-Investigator: Ellen Dammrich, APN Sub-Investigator: Mark Agulnik, MD Sub-Investigator: Frank Giles, MD Less <<
NCT00892736	Basal-Like Breast Carcinoma ... More >> BRCA1 Mutation Carrier BRCA2 Mutation Carrier Breast Carcinoma Estrogen Receptor Negative HER2/Neu Negative Hereditary Breast and Ovarian Cancer Syndrome Ovarian Carcinoma Pancreatic Carcinoma Progesterone Receptor Negative Prostate Carcinoma Recurrent Breast Carcinoma Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Solid Neoplasm Triple-Negative Breast Carcinoma Less <<	Phase 1	Completed	-	United States, California ... More >> City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 City of Hope South Pasadena South Pasadena, California, United States, 91030 United States, New Jersey Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 United States, Pennsylvania Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033-0850 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 Less <<
NCT01472783	Recurrent, Epithelial Ovarian ... More >>Cancer Less <<	Phase 1 Phase 2	Completed	-	Denmark ... More >> Department of Oncology, Vejle Hospital Vejle, Denmark, 7100 Less <<
NCT01009788	Breast Cancer ... More >> Metastatic Breast Cancer BRCA1 Gene Mutation brca2 Gene Mutation Less <<	Phase 2	Active, not recruiting	June 2020	United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Less <<
NCT01233505	Adenocarcinoma of the Pancreas... More >> Adenocarcinoma of the Stomach BRCA1 Mutation Carrier BRCA2 Mutation Carrier Ovarian Mucinous Cystadenocarcinoma Recurrent Breast Cancer Recurrent Colon Cancer Recurrent Gastric Cancer Recurrent Ovarian Epithelial Cancer Recurrent Ovarian Germ Cell Tumor Recurrent Pancreatic Cancer Recurrent Rectal Cancer Stage IA Breast Cancer Stage IB Breast Cancer Stage II Breast Cancer Stage IIIA Breast Cancer Stage IIIB Breast Cancer Stage IIIC Breast Cancer Stage IV Breast Cancer Stage IV Colon Cancer Stage IV Gastric Cancer Stage IV Ovarian Epithelial Cancer Stage IV Ovarian Germ Cell Tumor Stage IV Pancreatic Cancer Stage IV Rectal Cancer Unspecified Adult Solid Tumor, Protocol Specific Less <<	Phase 1	Terminated	-	United States, Wisconsin ... More >> University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Less <<
NCT01657799	Brain Metastases From Non-smal... More >>l Cell Lung Cancer Less <<	Phase 2	Completed	-	-
NCT01657799	-		Completed	-	-
NCT02412371	Non-small Cell Lung Cancer Sta... More >>ge III Less <<	Phase 1 Phase 2	Active, not recruiting	February 28, 2019	United States, California ... More >> Ucsd /Id# 133037 La Jolla, California, United States, 92037 United States, Delaware Christiana Care Health Service /ID# 133486 Newark, Delaware, United States, 19713 United States, Illinois University of Chicago /ID# 133828 Chicago, Illinois, United States, 60637-1443 United States, Maryland Univ Maryland School Medicine /ID# 132944 Baltimore, Maryland, United States, 21201 United States, Massachusetts Dana-Farber Cancer Institute /ID# 133494 Boston, Massachusetts, United States, 02215 United States, New York SUNY Upstate Medical Center /ID# 133492 Syracuse, New York, United States, 13210 United States, North Carolina Unc /Id# 133496 Chapel Hill, North Carolina, United States, 27599 Duke Univ Med Ctr /ID# 133497 Durham, North Carolina, United States, 27710 Wake Forest Univ HS /ID# 134608 Winston-Salem, North Carolina, United States, 27157 United States, Rhode Island Rhode Island Hospital /ID# 133493 Providence, Rhode Island, United States, 02903 The Miriam Hospital /ID# 133910 Providence, Rhode Island, United States, 02906 United States, Virginia University of Virginia /ID# 133495 Charlottesville, Virginia, United States, 22908 Less <<
NCT01193140	Solid Tumor Cancers	Phase 2	Completed	-	United States, California ... More >> Site Reference ID/Investigator# 43022 Encinitas, California, United States, 92024 Site Reference ID/Investigator# 42662 Santa Monica, California, United States, 90404 Less <<
NCT02595905	Breast Carcinoma Metastatic in... More >> the Brain Deleterious BRCA1 Gene Mutation Deleterious BRCA2 Gene Mutation Estrogen Receptor Negative HER2/Neu Negative Progesterone Receptor Negative Recurrent Breast Carcinoma Stage IV Breast Cancer AJCC v6 and v7 Triple-Negative Breast Carcinoma Less <<	Phase 2	Recruiting	-	-
NCT01589419	Locally Advanced Rectal Cancer	Phase 1	Completed	-	United States, Arizona ... More >> Site Reference ID/Investigator# 99095 Scottsdale, Arizona, United States, 85258 United States, Illinois Site Reference ID/Investigator# 68044 Chicago, Illinois, United States, 60611 United States, Indiana Site Reference ID/Investigator# 112395 Goshen, Indiana, United States, 46526 United States, North Carolina Site Reference ID/Investigator# 68045 Durham, North Carolina, United States, 27710 United States, Wisconsin Site Reference ID/Investigator# 68043 Madison, Wisconsin, United States, 53792 Australia Site Reference ID/Investigator# 67882 East Melbourne, Australia, 3002 Less <<
NCT02483104	Ovarian Cancer	Phase 1	Completed	-	Japan ... More >> Site Reference ID/Investigator# 128815 Kurume-shi,Fukuoka, Japan Site Reference ID/Investigator# 128997 Morioka-shi, Japan Site Reference ID/Investigator# 128058 Nagaizumi-cho, Japan Less <<
NCT01434316	Advanced Malignant Solid Neopl... More >>asm BRCA1 Gene Mutation BRCA2 Gene Mutation Less <<	Phase 1	Recruiting	-	United States, Massachusetts ... More >> Massachusetts General Hospital Cancer Center Recruiting Boston, Massachusetts, United States, 02114 Contact: Geoffrey I. Shapiro 617-632-4942 geoffrey_shapiro@dfci.harvard.edu Principal Investigator: Geoffrey I. Shapiro Brigham and Women's Hospital Recruiting Boston, Massachusetts, United States, 02115 Contact: Scott J. Rodig 617-525-7825 srodig@partners.org Principal Investigator: Scott J. Rodig Beth Israel Deaconess Medical Center Recruiting Boston, Massachusetts, United States, 02215 Contact: Gerburg M. Wulf 617-667-9925 Sub-Investigator: Gerburg M. Wulf Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Geoffrey I. Shapiro 617-632-4942 geoffrey_shapiro@dfci.harvard.edu Principal Investigator: Geoffrey I. Shapiro Massachusetts General Hospital Recruiting Charlestown, Massachusetts, United States, 02129 Contact: Jeffrey Supko 617-724-1970 jsupko@partners.org Principal Investigator: Jeffrey Supko Less <<
NCT03581292	Anaplastic Astrocytoma ... More >> Glioblastoma Malignant Glioma Less <<	Phase 2	Recruiting	October 29, 2024	-
NCT01199224	Solid Tumors	Phase 1	Completed	-	-
NCT03032614	Breast Cancer Stage IV ... More >> Ovarian Cancer BRCA1 Mutation BRCA2 Mutation Less <<	Phase 2	Withdrawn(Lack of funding)	April 30, 2020	-
NCT01540565	BRCA1 Mutation Carrier ... More >> BRCA2 Mutation Carrier Ovarian Epithelial Tumor Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Less <<	Phase 2	Completed	-	-
NCT02631733	Malignant Solid Neoplasm	Phase 1	Recruiting	-	United States, Maryland ... More >> Johns Hopkins University/Sidney Kimmel Cancer Center Recruiting Baltimore, Maryland, United States, 21287 Contact: Site Public Contact 410-955-8804 jhcccro@jhmi.edu Principal Investigator: Roisin M. Connolly National Institutes of Health Clinical Center Recruiting Bethesda, Maryland, United States, 20892 Contact: Site Public Contact 800-411-1222 Principal Investigator: Anish Thomas NCI - Center for Cancer Research Recruiting Bethesda, Maryland, United States, 20892 Contact: Site Public Contact 800-411-1222 Principal Investigator: Anish Thomas United States, Minnesota Mayo Clinic Recruiting Rochester, Minnesota, United States, 55905 Contact: Site Public Contact 855-776-0015 Principal Investigator: Ciara C. O'Sullivan United States, New York Columbia University/Herbert Irving Cancer Center Recruiting New York, New York, United States, 10032 Contact: Site Public Contact 212-305-6361 nr2616@cumc.columbia.edu Principal Investigator: Susan E. Bates United States, Ohio Cleveland Clinic Foundation Suspended Cleveland, Ohio, United States, 44195 Less <<
NCT01351909	HER2/Neu Negative ... More >> Recurrent Breast Carcinoma Stage IIIB Breast Cancer AJCC v7 Stage IIIC Breast Cancer AJCC v7 Stage IV Breast Cancer AJCC v6 and v7 Less <<	Phase 1	Active, not recruiting	-	United States, New York ... More >> Montefiore Medical Center-Einstein Campus Bronx, New York, United States, 10461 Montefiore Medical Center-Weiler Hospital Bronx, New York, United States, 10461 Montefiore Medical Center - Moses Campus Bronx, New York, United States, 10467 Laura and Isaac Perlmutter Cancer Center at NYU Langone New York, New York, United States, 10016 Columbia University/Herbert Irving Cancer Center New York, New York, United States, 10032 Less <<
NCT03044795	Cancer	Phase 2	Not yet recruiting	November 2020	Netherlands ... More >> University Medical Center Groningen Not yet recruiting Groningen, Netherlands, 9713 GZ Contact: J. A. Gietema, MD, PhD +31 50 3612821 j.a.gietema@umcg.nl Contact: M. Jalving, MD, PhD +31 50 3612821 m.jalving@umcg.nl Principal Investigator: J. A. Gietema, MD, PhD Erasmus MC Not yet recruiting Rotterdam, Netherlands Contact: A. Jager, MD, PhD +31 10 7041733 a.jager@erasmusmc.nl Principal Investigator: A. Jager, MD, PhD Less <<
NCT01908478	Pancreatic Cancer	Phase 1	Active, not recruiting	July 2020	United States, California ... More >> Cedars-Sinai Medical Center Los Angeles, California, United States, 90048 Less <<
NCT01690598	Ovarian Cancer	Phase 1 Phase 2	Completed	-	Denmark ... More >> Department of Oncology, Vejle Hospital Vejle, Denmark, DK-7100 Less <<
NCT02860819	Testicular Cancer	Phase 2	Recruiting	December 2018	Slovakia ... More >> National Cancer Institute Recruiting Bratislava, Slovakia, 83310 Contact: Michal Mego, Assoc. Prof +421259378 ext 366 michal.mego@nou.sk Contact: Jozef Mardiak, Prof +421259378 ext 108 jozef.mardiak@nou.sk Principal Investigator: Jozef Mardiak, Prof Principal Investigator: Michal Mego, Assoc. Prof Less <<
NCT03123211	-		-	-	-
NCT01123876	Gastric Cancer	Phase 1	Completed	-	United States, Arizona ... More >> Site Reference ID/Investigator# 24987 Scottsdale, Arizona, United States, 85258 United States, California Site Reference ID/Investigator# 24985 Los Angeles, California, United States, 90033 Site Reference ID/Investigator# 26742 Los Angeles, California, United States, 90033 United States, District of Columbia Site Reference ID/Investigator# 24986 Washington, District of Columbia, United States, 20007 United States, North Carolina Site Reference ID/Investigator# 24922 Durham, North Carolina, United States, 27710 United States, Tennessee Site Reference ID/Investigator# 24983 Nashville, Tennessee, United States, 37232-6868 Korea, Republic of Site Reference ID/Investigator# 75713 Seoul, Korea, Republic of, 138-736 Site Reference ID/Investigator# 75714 Seoul, Korea, Republic of Less <<
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CAS No. :	912444-00-9
Formula :	C₁₃H₁₆N₄O
M.W :	244.29
SMILES Code :	O=C(C1=C2NC([C@]3(C)NCCC3)=NC2=CC=C1)N
Synonyms :	ABT-888; NSC 737664
MDL No. :	MFCD16661059
InChI Key :	JNAHVYVRKWKWKQ-CYBMUJFWSA-N
Pubchem ID :	11960529

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H317
Precautionary Statements:	P280

MDA-MB-436	10-50 µM	72 hours	To evaluate the sensitivity of breast cancer cell lines to the PARP inhibitor ABT-888, results showed that only BRCA1-deficient MDA-MB-436 cells were sensitive to ABT-888.	Cancer Sci. 2011 Oct;102(10):1882-8.
RWPE-1	20uM	3 days	To evaluate the effect of SAHA and veliparib alone or in combination on the viability of normal prostate epithelial cells. Results showed no significant toxicity to normal cells.	J Exp Clin Cancer Res. 2018 Jul 16;37(1):153.
DU145	20uM	3 days	To evaluate the effect of SAHA and veliparib alone or in combination on cell viability. Results showed that co-treatment significantly decreased cell viability.	J Exp Clin Cancer Res. 2018 Jul 16;37(1):153.
C4–2	20uM	3 days	To evaluate the effect of SAHA and veliparib alone or in combination on cell viability. Results showed that co-treatment significantly decreased cell viability.	J Exp Clin Cancer Res. 2018 Jul 16;37(1):153.
LNCaP	20uM	3 days	To evaluate the effect of SAHA and veliparib alone or in combination on cell viability. Results showed that co-treatment significantly decreased cell viability.	J Exp Clin Cancer Res. 2018 Jul 16;37(1):153.
KKU-055 cells	0.1-100 μM	96 h	To evaluate the synergistic cytotoxic effects of BET inhibitors combined with PARP inhibitors in CCA cells, results showed that all combinations exhibited synergy.	Cancer Lett. 2020 Jan 1;468:48-58.
KKU-100 cells	0.1-100 μM	96 h	To evaluate the synergistic cytotoxic effects of BET inhibitors combined with PARP inhibitors in CCA cells, results showed that all combinations exhibited synergy.	Cancer Lett. 2020 Jan 1;468:48-58.
U2OS	10 μM	24 h	To evaluate the effect of Veliparib on DNA replication fork stability, results showed that Veliparib treatment increased the interaction between TIM and PARP1, indicating impaired TIM degradation.	Cell Rep. 2024 Mar 26;43(3):113845.
SH-SY5Y cells	10 µM	24 h	Veliparib effectively inhibited PARP activity and significantly restored TOM40 protein levels while reducing α-Syn protein levels.	Cell Death Dis. 2024 Dec 18;15(12):914.
U2-OS cells	10 µM	25 h	Veliparib treatment led to a significant increase in micronuclei formation in U2-OS cells following HU treatment, indicating that Veliparib increases genomic instability under replication stress.	J Cell Biol. 2014 Aug 18;206(4):493-507.
MCF7GFP-IBD cells	10 μM	1 h	Veliparib combined with ionizing radiation (IR) suppressed colony formation in irradiated MCF7GFP-IBD cells compared with IR alone, similar to the activity of the PARP1/2 inhibitor veliparib, a well established radiosensitizer.	Mol Cancer Ther. 2018 Feb;17(2):407-418.
B16.SIY cells	25 μM	1 h	Veliparib significantly delayed DSB repair in B16.SIY cells after 6 Gy, with persistent damage reaching that of 12 Gy or 6 Gy plus 10 μM veliparib.	Mol Cancer Ther. 2018 Feb;17(2):407-418.

Nude mice	DU145 xenograft model	SAHA intraperitoneal injection, veliparib oral gavage	25 mg/kg/d	3 continuous weeks	To validate the antitumor effect of SAHA and veliparib co-treatment. Results showed that co-treatment significantly inhibited tumor growth.	J Exp Clin Cancer Res. 2018 Jul 16;37(1):153.
Mice	B16.SIY tumor model	Oral	10 mg/kg	Once daily for 5 days	Veliparib along with 15 Gy displayed increased tumor tissue destruction, increased DNA damage, decreased cellular proliferation, and enhanced senescence, and significantly delayed tumor growth.	Mol Cancer Ther. 2018 Feb;17(2):407-418.
Mice	Triple-negative breast cancer xenograft model	Oral	20 mg/kg, 60 mg/kg	Three times daily for three days	To evaluate the penetration and distribution of Veliparib in triple-negative breast cancer xenograft models, results showed that Veliparib penetration in tumors was highly heterogeneous and positively correlated with platinum adduct formation	Breast Cancer Res. 2017 Sep 11;19(1):107

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CAS No.: 912444-00-9

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CAS No.: 912444-00-9

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Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	4.09mL 0.82mL 0.41mL	20.47mL 4.09mL 2.05mL	40.94mL 8.19mL 4.09mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed