630-580-1088 sales@ambeed.com
Structure Search

List Search MOL Search Structure Search

0
Chemistry
Asymmetric Synthesis >>Chiral Building BlocksChiral Catalysts, Chiral Ligands and Chiral ReagentsChiral Resolution ReagentsCatalysis Chemistry >>Achiral Crown LigandsC-H ActivationCarbon-Donor LigandsChiral Crown LigandsCross-CouplingCross-Coupling Using Transition Metal CatalystsDACH or Trost LigandsDiketone LigandsHydrogenationChemical Biology >>Conjugation ChemistryGlycoscienceLinkers and CrosslinkersNucleic Acid ChemistryPEGylation
Peptide ChemistryPhotolabile Protecting GroupHeterocyclic Building Blocks >>Acridinium SeriesAliphatic HeterocyclesAromatic HeterocyclesAzetidinesBenzimidazolesBenzisoxazolesBenzodioxansBenzofuransBenzothiazolesInorganic reagents >>Inorganic reagentOrganic Building Blocks >>Acyl ChloridesAlcoholsAldehydesAliphatic Chain HydrocarbonsAliphatic Cyclic Hydrocarbons
AlkenylsAlkylsAlkynylsAmidesOrganometallic Reagents >>Grignard ReagentsOrganoarsenicOrganobismuthOrganoboronOrganogermaniumOrganolithiumOrganomercuryOrganosiliconOrganotinSpecialty Synthesis >>Enzyme-Mediated SynthesisFluorous SynthesisIonic LiquidsSolid Supported SynthesisStains and Dyes >>
Acid DyesAzoic DyesBasic DyesDirect DyesDisperse DyesDye IntermediatesMordant DyesOil DyesOther Stains and DyesSynthetic Reagents >>Acids and BasesC-C Bond FormationC-X Bond Formation (Halogen)C-X Bond Formation (Non-Halogen)Chelation and Complexation CompoundsCondensation AgentsCouplingDehydrating ReagentsFluorination Reagents
Pharmaceutical Intermediates
Analgesics >>BenzhydrocodoneBicifadineDebio-0827Parecoxib PregnanoloneSpiradolineTapentadol Zucapsaicin RelatedAnesthetics >>Fospropofol Levobupivacaine RemimazolamRemimazolam besylateRopivacaineAnti-Addiction Agents >>KakoneinVarenicline Anti-inflammatory Agents >>ATB-346 RelatedBalsalazide Celecoxib Related
DilmapimodEsflurbiprofenEtoricoxibFilgotinib RelatedFlobufenGrapiprant RelatedAntibacterials >>AFN-1252 RelatedAlatrofloxacin Besifloxacin BrilacidinCefilavancinCeftaroline Fosamil Ceftizoxime AlapivoxilCethromycin RelatedDaptomycin RelatedAnticonvulsants >>BrivaracetamEslicarbazepine Acetate RelatedGabapentin EnacarbilJNJ-10234094Levetiracetam Related
LosigamoneNaluzotanPerampanelPregabalinAntidementia Agents >>Azeliragon RelatedDavunetideDonepezil RelatedEnsaculinIdalopirdineLanabecestatNTC-942SB 742457Semagacestat RelatedAntidepressants >>4-ChlorokynurenineAgomelatine RelatedAllopregnanolone RelatedAmibegronAmitifadineAripiprazole RelatedBasimglurant
BefloxatoneBefuralineAntiemetics >>Aprepitant RelatedDolasetron RelatedFosaprepitant RelatedPalonosetron RelatedRolapitant RelatedAntifungals >>Anidulafungin RelatedCaspofungin Eberconazole Efinaconazole RelatedG1Isavuconazonium Sulfate RelatedLuliconazole RelatedMicafungin RelatedMK 3118Antigout Agents >>ArhalofenateFebuxostat RelatedMore >>
Inhibitors/Agonists
ADCs >>ADC LinkerADC Linker with PayloadAnti-infection >>AntibacterialAntifungalAntiparasiticCCRCMVDengue VirusFilovirusHBVHCVApoptosis >>Apoptosis InducerBcl-2c-Mycc-RETCaspaseDAPKFASG-quadruplex
IAPAutophagy >>CXCRLRRK2MLKOther AutophagysSPHKULKBiochemical Reagent >>Intermediate and OthersBiochemical Reagents >>Biochemical Assay ReagentBiochemicals and Reagents(for Research and Experimental Use)Dye ReagentIntermidate and OthersCell Cycle >>ADC ToxinAPCAurora Kinasec-MycCasein KinaseCDK
ChkCRM1DHFRCytoskeleton >>AktArp2/3 ComplexBcr-AblDynaminFAKGap Junction ProteinHSPIntegrinKinesinDNA Damage >>ATM/ATRDNA Alkylator/CrosslinkerDNA-PKDNA/RNA SynthesisHDACMTH1PARPMore >>
Material Science
Electronic Materials >>Battery MaterialsDye-Sensitized Solar Cell (DSSC) MaterialsElectronic MaterialLiquid Crystal (LC) MaterialsMolecular ConductorsOrganic Light-Emitting Diode (OLED) MaterialsOrganic Solar Cell (OPV) MaterialsOrganic Transistor (OFET) MaterialsPerovskite Solar Cell (PSC) MaterialsMagnetic Materials >>Magnetic Ionic LiquidsMagnetic MaterialMagnetic Metal Complexes Organic Radicals Material Building Blocks >>Ligands for Functional Metal ComplexesLiquid Crystal (LC) Building BlocksPhthalocyanine Building BlocksPolymer and Macromolecule Semiconductor Building BlocksSmall Molecule Semiconductor Building BlocksSolubility Enhancing Reagents Supramolecular Host Materials Nanomaterials >>
Carbon NanomaterialsCeramic MembranesDendrimersGold NanoparticlesIron Oxide NanoparticlesMaterials by ApplicationMesoporous MaterialsMetals and Metal AlloysNano Minerals: NanoclaysOptical Materials >>Coumarin DyesCyanine and Squarylium DyesDCM DyesDipyrromethene DyesFluorescence MaterialsFluorescent ProbesHeat and Pressure Sensitive DyesNear-Infrared (NIR) DyesOrganic Non-Linear Optical (NLO) MaterialsOrganic ligands for MOF materials >>Carboxylic MOF ligandsHalogen seriesMOF ligands of nitrogenous carboxylic acidsNitrogen containing MOF ligands
Organic frame monomer blockOther MOF ligandsPorphyrin seriesTwo dimensional MOF ligandsOrganic monomer of COF >>Aldehyde based COF monomerAlkynyl COF monomerAmino COF monomerBoric acid COF monomerCyano COF monomerMultifunctional COF monomerOther COF monomerTriphene seriesOrganic Pigments >>Organic PigmentOther Materials >>Mateial OtherPolymer Science >>MonomersPolymer AdditivesPolymerization ReagentsPolymersResins
Life Science
ADC-linkers >>ADC-linkerAmino Acids >>Amino AcidAmino Acid DerivativesAnalytical Science >>Stable IsotopesAPIs >>API
DNA/RNA >>Nucleosides and NucleotidesEnzymes >>EnzymeOther Life Science >>CRISPR/Cas9eIFIRE1Neuronal Signaling
Sigma ReceptorPeptides >>PeptideStandard Substrates >>Standard SubstrateSteroids >>Other Steroids
Contact Us
Home Cart 0 Sign in  

[ CAS No. 912846-64-1 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 912846-64-1
Chemical Structure| 912846-64-1
Structure of 912846-64-1 *Storage: {[proInfo.prStorage]}

Search after Editing

*Storage: {[proInfo.prStorage]}

For Research Only 60,000+Inventories Competitive Price 1-2 days Fast Delivery

Quality Control of [ 912846-64-1 ]

COA GC NMR CNMR HPLC LC-MS

Related Doc. of [ 912846-64-1 ]

SDS

Product Details of [ 912846-64-1 ]

CAS No. :912846-64-1MDL No. :
Formula : C11H9F4NO Boiling Point : -
Linear Structure Formula :-InChI Key :-
M.W :247.19Pubchem ID :-
Synonyms :

Computed Properties of [ 912846-64-1 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 912846-64-1 ]

Signal Word:Class
Precautionary Statements:UN#:
Hazard Statements:Packing Group:

Application In Synthesis of [ 912846-64-1 ]

  • Downstream synthetic route of [ 912846-64-1 ]

[ 912846-64-1 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 912846-64-1 ]
  • 2-(3-cyclopropyl-8-methyl[1,2,4]triazolo[3,4-a]phthalazin-6-yl)-7-fluoro-1,2,3,4-tetrahydroisoquinolin-6-amine [ No CAS ]
Reference： [1]Patent: WO2019/133666,2019,A1
  • 2
  • [ 912846-64-1 ]
  • 2-(3-cyclopropyl-9-methyl[1,2,4]triazolo[3,4-a]phthalazin-6-yl)-7-fluoro-1,2,3,4-tetrahydroisoquinolin-6-amine [ No CAS ]
Reference： [1]Patent: WO2019/133666,2019,A1
  • 3
  • [ 912846-64-1 ]
  • C9H11FN2 [ No CAS ]
Reference： [1]Patent: WO2019/133666,2019,A1
  • 4
  • [ 912846-64-1 ]
  • C11H10F4N2O [ No CAS ]
Reference： [1]Patent: WO2019/133666,2019,A1
  • 5
  • [ 912846-64-1 ]
  • [ 912846-66-3 ]
Reference： [1]Patent: WO2006/108709,2006,A1
  • 6
  • [ 912846-64-1 ]
  • N-methyl-7-cyclopropoxy-1,2,3,4-tetrahydroisoquinoline-6-amine [ No CAS ]
Reference： [1]Patent: EP3150592,2017,A1
  • 7
  • [ 912846-64-1 ]
  • N-methyl-7-cyclopropoxy-6-nitro-1,2,3,4-tetrahydroisoquinoline [ No CAS ]
Reference： [1]Patent: EP3150592,2017,A1
  • 8
  • [ 912846-64-1 ]
  • 7-fluoro-2-methyl-6-nitro-1,2,3 ,4-tetrahydroisoquinoline [ No CAS ]
Reference： [1]Patent: EP3150592,2017,A1
  • 9
  • [ 912846-64-1 ]
  • C26H23F2N5 [ No CAS ]
Reference： [1]Patent: CN105254613,2016,A
  • 10
  • [ 912846-64-1 ]
  • [ 406923-91-9 ]
YieldReaction ConditionsOperation in experiment
47% With methanol; sodium carbonate; at 60℃; for 1.0h; The A23-3 (200mg, 0.81mmol), saturated aqueous sodium carbonate (0.8 mL of) and methanol (0.8 mL of) added to the flask, followed by stirring at 60 1h, the methanol was removed spin, water was added to 15mL, extracted three times with ethyl acetate, the combined organic phase was washed once with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate,Rotary did a colorless oily compound (58mg, 47%).
With potassium carbonate; In methanol; water; at 20℃; for 5.0h; 2,2,2-Trifluoro-1-(7-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)ethanone (500 mg, 2.02 mmol) dissolved in Methanol (10 mL)/Water (4 mL) was added K2CO3 (2.9 g, 20.23 mmol) and continued to stir at room temperature for 5 h. After reaction completion, evaporated off the solvents and the solid was re-diluted with water (50 mL) and extracted with chloroform (3 X 50 mL). The combined organic extracts were then dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. A colorless viscous oil was obtained in 71% yield (217 mg) which was used in next step without purification. 1H NMR (400 MHz, DMSO-d6) delta 7.08 (dd, J = 8.4, 6.0 Hz, 1H), 6.91 (td, J = 8.7, 2.8 Hz, 1H), 6.84 (dd, J = 9.8, 2.8 Hz, 1H), 3.81 (s, 2H), 3.07 (br.s, 1H), 2.90 (t, J = 5.9 Hz, 2H), 2.63 (t, J = 6.0 Hz, 2H). LRMS: (M+H)+ = 152.1 m/z. Yield: 71%.
Reference： [1]Patent: CN105254613,2016,A.Location in patent: Paragraph 0171; 0176; 0177
[2]Patent: WO2019/133666,2019,A1.Location in patent: Paragraph 00450

Tags: 912846-64-1; 7-Fluoro-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline;

Related Products
Historical Records