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Chemical Structure| 913719-86-5 Chemical Structure| 913719-86-5

Structure of 913719-86-5

Chemical Structure| 913719-86-5

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Product Details of [ 913719-86-5 ]

CAS No. :913719-86-5
Formula : C10H9F2N
M.W : 181.18
SMILES Code : CC(C)(C1=CC=CC(F)=C1F)C#N
MDL No. :MFCD11036563

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Application In Synthesis of [ 913719-86-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 913719-86-5 ]

[ 913719-86-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 145689-34-5 ]
  • [ 74-88-4 ]
  • [ 913719-86-5 ]
YieldReaction ConditionsOperation in experiment
With sodium hydride; In 1-methyl-pyrrolidin-2-one; diethyl ether; at 20℃; for 15h; Step A: Preparation of 2-(2,3-Difiuorophenyl)-2- methylpropanenitrile; [0389] A mixture of NaH (5.7 g, 144 mmol) in 100 mL NMP stirred atO0C, was treated dropwise with a mixture of MeI (9.0 mL, 144 mmol) and 2- <strong>[145689-34-5](2,3-difluorophenyl)acetonitrile</strong> (10 g, 65 mmol) in 50 mL ether. The mixture was stirred at room temperature for 15 hours. The mixture was then carefully quenched with 20 mL H2O and extracted with ether (3 x 100 mL). The combined organic layers were washed with H2O (2 x 50 mL) and brine (20 mL), dried over anhydrous Na2SO4, concentrated in vacuo, and purified by column chromatography eluting with 10-20 % EtOAc/hexane to give 1 1.4 g of the title compound as a pale yellow oil.
 

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