Alternatived Products of [ 913835-51-5 ]
Product Details of [ 913835-51-5 ]
CAS No. : | 913835-51-5 |
MDL No. : | MFCD08689480 |
Formula : |
C11H13BO4
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | UIZGQEYEJKAASO-VOTSOKGWSA-N |
M.W : |
220.03
|
Pubchem ID : | 44119341 |
Synonyms : |
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Safety of [ 913835-51-5 ]
Application In Synthesis of [ 913835-51-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 913835-51-5 ]
- 1
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[ 913835-51-5 ]
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[ 125114-77-4 ]
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(E)-ethyl 3-(3-(3-oxo-2,3-dihydro-1H-inden-4-yl)phenyl)acrylate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
90% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; toluene; at 80℃;Inert atmosphere; Sealed tube; |
A mixture of 7-bromo-2,3- dihydro-lH-inden-l-one (100 mg, 0.48 mmol), (E)-(3-(3-ethoxy-3-oxoprop-l-en-l- yl)phenyl)boronic acid (210 mg, 0.95 mmol), and K2C03 (133 mg, 0.96 mmol) in toluene (66 mL)/EtOH (22 mL) was purged with N2. (Ph3P)4Pd (55 mg, 0.048 mmol) was added and the mixture was heated in a sealed tube at 80 C overnight. The mixture was allowed to cool to room temperature and the volume was reduced in half. H20 (100 mL) was added and the resulting mixture was extracted with ethyl acetate (3 x 40 mL). The combined organic solution was washed with brine and then was dried (Na2S04), filtered and evaporated. Purification of the crude product by flash chromatography on silica gel using a Combiflash unit by Teledyne Isco (ethyl acetate/hexanes) gave the title compound (133 mg, 90%). |